The Necessity and the Value of Placebo

Science and Engineering Ethics

Volumn 10, Issue 1, 2004, Pages 51-56

  Singer, Ernst A ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Antidepressants; Assay sensitivity; Comparator; Control; Placebo control

Indexed keywords

ANTIANDROGEN; ANTIARRHYTHMIC AGENT; ANTIDEPRESSANT AGENT; DESLORATADINE; FLUTAMIDE; MONOCLONAL ANTIBODY; PLACEBO; SUMATRIPTAN; ZOLMITRIPTAN;

ALLERGIC RHINITIS; ALLERGY; ANXIETY DISORDER; CLINICAL TRIAL; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; DEMENTIA; DEPRESSION; DRUG EFFECT; DRUG EFFICACY; GASTROESOPHAGEAL REFLUX; HEART INFARCTION; HUMAN; MEDICAL ETHICS; METASTASIS; MIGRAINE; PROSTATE CANCER; SEPTIC SHOCK; SIDE EFFECT; TREATMENT OUTCOME;

EID: 1242284496     PISSN: 13533452     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11948-004-0062-0     Document Type: Conference Paper

References (11)

1. Rothman KJ and Michels, KB (1994) The continuing unethical use of placebo controls, New England Journal of Medicine 331: 394-398.
2. World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects. Available at: http://www.wma.net/e/policy
3. Vastag B (2000) Helsinki discord? A controversial declaration, Journal of the American Medical Association 284: 2983-2985
4. Forster HP, Emanuel E and Grady C (2001) The 2000 revision of the Declaration of Helsinki: a step forward or more confusion?, Lancet 358: 1449-1453.
5. Echt DS., Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L and Greene HL (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial, New England Journal of Medicine 324: 781-788.
6. McCloskey RV, Straube RC, Sanders C, Smith SM and Smith CR (1994) Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS Trial Study Group, Annals of Internal Medicine 121: 1-5.
7. Eisenberger MA, Blumenstein BA, Crawford ED, Miller G, McLeod DG, Loehrer PJ, Wilding G, Sears K, Culkin DJ, Thompson IM Jr, Bueschen AJ and Lowe BA (1998) Bilateral orchiectomy with or without flutamide for metastatic prostate cancer, New England Journal of Medicine 339: 1036-1042.
8. European Agency for the Evaluation of Medicinal Products. European Public Assessment Report (EPAR) on Azomyr (desloratadine). Available at: http://www.emea.eu.int.
9. Schoenen J and Sawyer J (1997) Zolmitriptan (Zomig, 311C90), a novel dual central and peripheral 5HT1B/1D agonist: an overview of efficacy, Cephalagia 17 (Suppl. 18): 28-40.
10. Leber PD (1989) Hazards of inference: the active control investigation, Epilepsia 30 Suppl. 1: S57-S63.
11. Emanuel EJ and Miller FG (2001) The ethics of placebo-controlled trials - a middle ground, New England Journal of Medicine 345: 915-919.