Studies on the Synthesis of Penazetidine A, an Alkaloid Inhibitor of Protein Kinase C

Chinese Chemical Letters

Volumn 15, Issue 2, 2004, Pages 138-140

  Li, Zhi Ming ^a   Wang, Bing ^b   Tao, Feng Gang ^a   Lin, Guo Qiang ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Alkaloid; Azetidine; Penazetidine A; Wittig reaction

Indexed keywords

3 HYDROXY 2 HYDROXYMETHYL 4 (12' METHYLOCTADECYL) N (4 TOLYLSULFONYL)AZETIDINE; ALKALOID; AZETIDINE DERIVATIVE; DIVINYLCARBINOL; METHANOL DERIVATIVE; PENAZETIDINE A; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; PRECURSOR;

EID: 1242273825     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. K. A. Alvi, M. Jaspars, P. Crews, Bioorg. Med. Chem. Lett., 1994, 4, 2447.
2. A. Yajima, H. Takikawa, K. Mori, Liebigs Ann., 1996, 1083.
3. S. Knapp, Y. Dong, Tetrahedron Lett., 1997, 38, 3813.
4. D. G. Liu, G. Q. Lin, Tetrahedron Lett., 1999, 40, 337.
5. W. Oppolzer, C. Chapuis, G. Bernadinelli, Helv. Chim. Acta., 1984, 67, 1397.
6. F. A. Davis, J. C. Towson, M. C. Weismiller, S. Lal, P. J. Carrol, J. Am. Chem. Soc., 1988, 110, 8477.
7. A. Solladié-Cavallo, A. Adib, Tetrahedron Lett., 1992, 48, 2453.
8. Synthesis of 9-tetrahydropyranoxy-1-nonyl magnesium bromide: commercially available 9-bromononanol was protected as DHP derivative, and was subsequently converted to Grignard reagents.
9. 4S 523.3695, found 523.3725.