Inhibition of Erythropoietin Activity by Cyanate

Scandinavian Journal of Urology and Nephrology

Volumn 38, Issue 1, 2004, Pages 69-72

  Park, Kyung Dae ^a   Mun, Kyo Cheol ^a   Chang, Eun Ju ^a   Park, Sung Bae ^a   Kim, Hyun Chul ^a  

^a Keimyung University School of Medicine   (South Korea)

Author keywords

Carbamylation; Cyanate; Erythropoietin; Kidney failure

Indexed keywords

AMINO ACID; CYANIC ACID; ERYTHROPOIETIN; HEMOGLOBIN; TRINITROBENZENESULFONIC ACID; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HEMATOCRIT; INCUBATION TIME; INHIBITION KINETICS; KIDNEY FAILURE; LEUKOCYTE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; RAT;

ANIMALS; CYANATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ERYTHROPOIESIS; ERYTHROPOIETIN; INJECTIONS, SUBCUTANEOUS; MALE; MODELS, ANIMAL; PROBABILITY; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 1242272769     PISSN: 00365599     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365590310006291     Document Type: Article

References (20)

1. Morris K, Coulthard M. End-stage kidneys are capable of increased erythropoietin production. Pediatr Nephrol 1993; 7: 273-5.
2. Wallner SF, Vautrin RM. Evidence that inhibition of erythropoiesis is important in the anemia of chronic renal failure. J Lab Clin Med 1981; 97: 170-8.
3. Remuzzi G, Minetti L. Hematologic consequence of renal failure. In: Brenner BM, ed. Brenner and Rector's the kidney, 6th edn. Philadelphia, PA: Saunders, 2000: 2079-102.
4. Ifudu O, Feldman J, Friedman EA. The intensity of hemodialysis and the response to erythropoietin in patients with end-stage renal disease. N Engl J Med 1996; 334: 420-5.
5. Opatrna S, Opatrny K, Jr, Cejkova P, Sefrna F, Hostasova A, Opatrny K. Relationship between anemia and adequacy of continuous ambulatory peritoneal dialysis. Nephron 1997; 77: 359-60.
6. Stojimirovic B, Grujic-Adanja G. The effect of hemodialysis and continuous peritoneal dialysis on renal anemia. Srp Arh Celok Lek 1997; 125: 163-7.
7. Marier JR, Rose D. Determination of cyanate, a study of its accumulation in aqueous solutions of urea. Anal Biochem 1964; 7: 304-14.
8. Bailey JL, Mitch WE. The pathophysiology of uremia. In: Brenner BM, ed. Brenner and Rector's the kidney, 6th edn. Philadelphia, PA: Saunders, 2000: 2059-78.
9. Fluckiger R, Harmon W, Meier W, Gabbay KH. Hemoglobin carbamylation in uremia. N Engl J Med 1981; 4: 823-7.
10. Kraus LM, Jones MR, Kraus AP, Jr. Essential carbamoyl-amino acids formed in vivo in patients with end-stage renal disease managed by continuous ambulatory peritoneal dialysis: isolation, identification, and quantitation. J Lab Clin Med 1998; 131: 425-31.
11. Roxborough HE, Millar CA, McEneny J, Young IS. Carbamylation inhibits the ferroxidase activity of caeruloplasmin. Biochem Biophys Res Commun 1995; 214: 1073-8.
12. Stark GR, Stein WH, Moore S. Reactions of the cyanate present in aqueous urea with amino acids and proteins. J Biol Chem 1960; 235: 3177-81.
13. Stark GR. Modification of proteins with cyanate. Methods Enzymol 1967; 11: 590-4.
14. Stim J, Shaykh M, Anwar F, Ansari A, Arruda JAL, Dunea G. Factors determining hemoglobin carbamylation in renal failure. Kidney Int 1995; 48: 1605-10.
15. Balion CM, Draisey TF, Thibert RJ. Carbamylated hemoglobin and carbamylated plasma protein in hemodialyzed patients. Kidney Int 1998; 53: 488-95.
16. Nilsson L, Lundquist P, Kagedal B, Larsson R. Plasma cyanate concentrations in chronic renal failure. Clin Chem 1996; 42: 482-3.
17. Kraus LM, Kraus AP, Jr. Carbamoylation of amino acids and proteins in uremia. Kidney Int Suppl 2001; 78: S102-7.
18. Mun KC, Golper TA. Impaired biological activity of erythropoietin by cyanate carbamylation. Blood Purif 2000; 18: 13-7.
19. Horkko S, Savolainen MJ, Kervinen K, Kesaniemi YA. Carbamylation-induced alterations in low-density lipoprotein metabolism. Kidney Int 1992; 41: 1175-81.
20. Allebban Z, Gibson LA, Lange RD, Jago TL, Strickland KM, Johnson DL, et al. Effects of spaceflight on rat erythroid parameters. J Appl Physiol 1996; 81: 117-22.