Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality

International Journal of Gynecological Cancer

Volumn 13, Issue 4, 2003, Pages 515-517

  Sindos, Michael ^a,b   Ndisang, D ^a   Pisal, N ^b   Chow, C ^b   Deery, A ^c   Singer, A ^b   Latchman, D ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b WHITTINGTON HOSPITAL   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Brn 3a; Cervical smear; Persistent borderline and mild dyskaryosis

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR POU4F1; UNCLASSIFIED DRUG; VIRUS DNA;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER SCREENING; COLPOSCOPY; CONTROLLED STUDY; DYSKARYOSIS; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY; UTERINE CERVIX TUMOR; WART VIRUS;

ADULT; AGED; BIOPSY, NEEDLE; CERVICAL INTRAEPITHELIAL NEOPLASIA; COHORT STUDIES; COLPOSCOPY; DNA-BINDING PROTEINS; FEMALE; GENETIC MARKERS; HUMANS; IMMUNOHISTOCHEMISTRY; MASS SCREENING; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; SENSITIVITY AND SPECIFICITY; TRANSCRIPTION FACTOR BRN-3A; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS;

EID: 1242271982     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1438.2003.13303.x     Document Type: Article

References (6)

1. Ndisang D, Morris PJ, Chapman C et al. The HPV activating transcription factor Brn-3a is over expressed in CIN3 lesions. J Clin Invest 1998;101:1687-92.
2. Ndisang D, Burhram-Mahadeo V, Latchman DS. The Brn-3a transcription factor plays a critical role in regulating human papilloma virus gene expression and determining the growth characteristics of cervical cancer cells. J Biol Chem 1999;274:28521-7.
3. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979;18:5294-9.
4. Souter WP, Wisdom S, Brough AK, Monaghan JM. Should patients with mild atypia in a cervical smear be referred for colposcopy? Br J Obstet Gynaecol 1986;93:70-4.
5. Bolger BS, Lewis BV. A prospective study of colposcopy in women with mild dyskaryosis or koilocytosis. Br J Obstet Gynaecol 1988;95:1117-9.
6. Flannelly G, Anderson D, Kitchener HC et al. Management of women with mild and moderate cervical dyskaryosis. BMJ 1994;308:399-403.