The inhibition by quercetin and ganhuangenin on oxidatively modified low density lipoprotein

Phytotherapy Research

Volumn 12, Issue 5, 1998, Pages 340-345

  Lim, Beong Ou ^a   Yu, Byung Pal ^a   Cho, Seong Il ^b   Her, Erk ^c   Park, Dong Ki ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Konkuk University   (South Korea)

^c Konkuk University School of Medicine   (South Korea)

Author keywords

Atherosclerosis; Flavonoids; Ganhuangenin; Oxidized LDL; Quercetin

Indexed keywords

COPPER; GANHUANGENIN; LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE HYDROPEROXIDE; PLANT EXTRACT; QUERCETIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; INCUBATION TIME; LIPID PEROXIDATION; OXIDATIVE STRESS; PLANT ROOT; PROTEIN MODIFICATION; QUANTITATIVE DIAGNOSIS;

EID: 1242268144     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1573(199808)12:5<340::AID-PTR316>3.0.CO;2-U     Document Type: Article

References (28)

1. Brandi, M. L. (1992). Flavonoids: biochemical effects and therapeutic applications. Bone Mineral 19, S3-S14.
2. Brown, M. S., and Goldstein, J. L. (1983). Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 52, 223-261.
3. Buege, J. A., and Aust, S. D. (1978). Microsomal lipid peroxidation. Methods Enzymol. 52, 302-310.
4. Haberland, M. E., Fogelman, A. M., and Edwards, P. A. (1982). Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins. Proc. Natl. Acad. Sci. USA 79, 1712-1716.
5. Harbone, J. B. ed., (1988). The Flavonoids: Advances in Research Since 1980. Chapman & Hall, London.
6. Havel, R. J., Eder, H. A., and Bragdon, J. H. (1955). The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34, 1345-1353.
7. Havsteen, B. (1983). Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharmacol. 32, 1141-1148.
8. Heller, W., and Forkmann, G. (1993). Biosynthesis of flavonoids. In The Flavonoid: Advances in Research Since 1986, ed. by J. B. Harbone, pp. 499-535. Chapman & Hall, London.
9. Henriksen, T., Mahoney, E. M., and Steinberg, D. (1981). Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc. Natl Acad. Sci. USA 78, 6499-6503.
10. Jessup, W., Rankin, S. M., de Whalley, C. V., Hoult, J. R., Scott, J., and Leake, D. S. (1990). Alpha-tocopherol consumption during low-density-lipoprotein oxidation. Biochem. J. 265, 399-405.
11. Jialal, I., Vega, G. L., and Grundy, S. M. (1990). Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein. Atherosclerosis 82, 185-191.
12. Kato, N., Tosa, N., Doudou, T., and Imamura, T. (1983). Effects of dietary quercetin on serum lipids. Agric. Biol. Chem. 47, 2119-2120.
13. Kim, S. C., Choi, O. B., Oh, J. H., and Park, D. K. (1996). Effects of ganhuangenin obtained from Scutellaria baicalensis Georgion the peroxidation of phospholipid. Int. Soc. Free Radic. Res. 8, 114 (Abstract).
14. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. T. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
15. Middleton, E. (1984). The flavonoids. TIPS 5, 335-338.
16. Miyazawa, T., Suzuki, T., Fujimoto, K., and Yasuda, K. (1992). Chemiluminescent simultaneous determination of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide in the liver and brain of the rat. J. Lipid Res. 33, 1051-1059.
17. Naruszewicz, M., Selinger, E., and Davignon, J. (1992). Oxidative modification of lipoprotein (a) and the effect of beta-carotene. Metabolism: Clin. Exp. 41, 1215-1224.
18. Noguchi, N., Gotoh, N., and Niki, E. (1993). Dynamics of the oxidation of low density lipoprotein induced by free radicals. Biochim. Biophys. Acta 1168, 348-357.
19. Ramanathan, R., Das, N. P., and Tan, C. H. (1994). Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and tipid peroxidation. Free Radic. Biol. Med. 16, 43-48.
20. Ratty, A. K., Sunamoto, J., and Das, N. P. (1988). Interaction of flavonoids with 1,1-diphenyl-2-picrylhydrazyl free radical, liposomal membranes and soybean lipoxygenase-1. Biochem. Pharmacol. 37, 989-995.
21. Saija, A., Scalese, M., Lanza, M., Marzullo, D., Bonina, F., and Castelli, F. (1995). Flavonoids as antioxidant agents: Importance of their interaction with biomembranes. Free Radic. Biol. Med. 19, 481-486.
22. Seo, T., Wang, H. C., Feldman, S. R., and St. Clair, R. W. (1997). Characterization of alpha 2-macroglobulin receptor low density lipoprotein receptor-related protein (alpha 2 MR/LRP) in white Carneau pigeon peritoneal macrophages: its role in lipoprotein metabolism. Biochem. Biophys. Acta 1344, 171-188.
23. Sevanian, A., Hwang, J., Hodies, H., Cazzolato, G., Avogaro, P., and Bittolo, B. G. (1996). Contribution of an in vivo oxidized LDL to LDL oxidation and its association with dense LDL subpopulations. Arter. Thrombi. Vasc. Biol. 16, 784-793.
24. Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C., and Witztum, J. L. (1989). Beyond cholesterol. Modification of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320, 915-924.
25. Steinbrecher, U. P. (1987). Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. J. Biol. Chem. 262, 3603-3608.
26. Steinbrecher, U. P., Lougheed, M., Kwan, W. C., and Drinds, M. (1989). Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivitization of apolipoprotein B by products of fatty acid peroxidation. J. Biol. Chem. 264, 15216-15223.
27. Terao, J., Piskula, M., and Yao, Q. (1994). Protective effect of epicatechin, epicatechin gallate, and quercetin on lipid peroxidation in phospholipid bilayers. Arch. Biochem. Biophys. 308, 278-284.
28. van Acker, S. A., van den Berg, D. J., and Tromp, M. N. et al. (1996). Structural aspects of antioxidant activity of flavonoids. Free Radic. Biol. Med. 20, 331-342.