Pancreatic autoantibodies in Crohn's disease: A feasible diagnostic tool?

European Journal of Gastroenterology and Hepatology

Volumn 17, Issue 1, 2005, Pages 37-39

  Torok H P ^a   Folwaczny, C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Crohn's disease; Pancreatic autoantibodies; Vienna classification

Indexed keywords

AUTOANTIBODY; CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERCELLULAR ADHESION MOLECULE 1; NEUTROPHIL CYTOPLASMIC ANTIBODY; PANCREAS AUTOANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY BLOOD LEVEL; COLITIS; CROHN DISEASE; DISEASE CLASSIFICATION; DISEASE MARKER; HUMAN; PANCREAS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

AUTOANTIBODIES; BIOLOGICAL MARKERS; CROHN DISEASE; HUMANS; PANCREAS, EXOCRINE;

EID: 12344328445     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200501000-00008     Document Type: Review

References (37)

1. Glas J, Török HP, Vilsmaier F, Herbinger KH, Hoelscher M, Folwaczny C. Anti-Saccharomyces cerevisiae antibodies in patients with inflammatory bowel disease and their first-degree relatives: potential clinical value. Digestion 2002; 66:173-177.
2. Quinton JF, Sendid B, Reumaux D, Duthilleul P, Cortot A, Grandbastien B, et al. Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1998; 42:788-791.
3. Ruemmele FM, Targan SR, Levy G, Dubinsky M, Braun J, Seidman EG. Diagnostic accuracy of serologicai assays in pediatric inflammatory bowel disease. Gastroenterology 1998; 115:822-829.
4. Cambridge G, Rampton DS, Stevens TR, McCarthy DA, Kamm M, Leaker B. Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1992; 33:668-674.
5. Colombel JF, Reumaux D, Duthilleul P, Noel LH, Gower-Rousseau C, Paris JC, Cortot A. Antineutrophil cytoplasmic autoantibodies in inflammatory bowel diseases. Gastroenterol Clin Biol 1992; 16:656-660.
6. Shanahan F, Duerr RH, Rotter JI, Yang H, Sutherland LR, McElree C, et al. Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology 1992; 103:456-461.
7. Joossens S, Reinisch W, Vermeire S, Sendid B, Poulain D, Peeters M, et al. The value of serologic markers in indeterminate colitis: a prospective follow-up study. Gastroenterology 2002; 122:1242-1247.
8. Hoffman IE, Demetter P, Peeters M, De Vos M, Mielants H, Veys EM, De Keyser F. Anti-Saccharomyces cerevisiae IgA antibodies are raised in ankylosing spondylitis and undifferentiated spondyloarthropathy. Ann Rheum Dis 2003; 62:455-459.
9. Török HP, Glas J, Gruber R, Brumberger V, Strasser C, Kellner H, et al. Inflammatory bowel disease-specific autoantibodies in HLA-B27-associated spondyloarthropathies: increased prevalence of ASCA and pANCA. Digestion 2004; 70:49-54.
10. Seibold F, Weber P, Jenss H, Wiedmann KH. Antibodies to a trypsin sensitive pancreatic antigen in chronic inflammatory bowel disease: specific markers for a subgroup of patients with Crohn's disease. Gut 1991; 32:1192-1197.
11. Folwaczny C, Noehl N, Endres SP, Loeschke K, Fricke H. Antineutrophil and pancreatic autoantibodies in first-degree relatives of patients with inflammatory bowel disease. Scand J Gastroenterol 1998; 33:523-528.
12. Stocker W, Otte M, Scriba PC. Immunopathogenesis of Crohn's disease. Dtsch Med Wochenschr 1984; 109:1984-1986.
13. Seibold F, Mork H, Tanza S, Muller A, Holzhuter C, Weber P, Scheurlen M. Pancreatic autoantibodies in Crohn's disease: a family study. Gut 1997; 40:481-484.
14. Fricke H, Birkhofer A, Folwaczny C, Meister W, Scriba PC. Characterization of antigens from the human exocrine pancreatic tissue (Pag) relevant as target antigens for autoantibodies in Crohn's disease. Eur J Clin Invest 1999; 29:41-45.
15. Shanahan F. Antibody 'markers' in Crohn's disease: opportunity or overstatement? Gut 1997; 40:557-558.
16. Seibold F, Scheurlen M, Muller A, Jenss H, Weber P. Impaired pancreatic function in patients with Crohn's disease with and without pancreatic autoantibodies. J Clin Gastroenterol 1996; 22:202-206.
17. Landers CJ, Cohavy O, Misra R, Yang H, Lin YC, Braun J, Targan SR. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology 2002; 123:689-699.
18. Cohavy O, Bruckner D, Gordon LK, Misra R, Wei B, Eggena ME, et al. Colonic bacteria express an ulcerative colitis pANCA-related protein epitope. Infect Immun 2000; 68:1542-1548.
19. Cohavy O, Harth G, Horwitz M, Eggena M, Landers C, Sutton C, et al. Identification of a novel mycobacterial histone H1 homologue (HupB) as an antigenic target of pANCA monoclonal antibody and serum immunoglobulin A from patients with Crohn's disease. Infect Immun 1999; 67:6510-6517.
20. Seibold F, Brandwein S, Simpson S, Terhorst C, Elson CO. pANCA represents a cross-reactivity to enteric bacterial antigens. J Clin Immunol 1998; 18:153-160.
21. Klebl FH, Bataille F, Huy C, Hofstädter F, Schölmerich J, Rogler G. Association of antibodies to exocrine pancreas with subtypes of Crohn's disease. Eur J Gastroenterol Hepatol 2004; this issue.
22. Török HP, Glas J, Lohse P, Folwaczny C. Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients. Dig Dis 2003; 21:339-345.
23. Folwaczny C, Noehl N, Endres SP, Loeschke K, Fricke H. Antineutrophil and pancreatic autoantibodies in first-degree relatives of patients with inflammatory bowel disease. Scand J Gastroenterol 1998; 33:523-528.
24. Seibold F, Slametschka D, Gregor M, Weber P. Neutrophil autoantibodies: a genetic marker in primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1994; 107:532-536.
25. Folwaczny C, Loeschke K, Schnettler D, Jager G, Wiebecke B, Hoelscher M, et al. Endothelial cell autoantibodies are a marker of disease susceptibility in inflammatory bowel disease but apparently not linked to persistent measles virus infection. Clin Immunol 2000; 95:197-202.
26. Folwaczny C, Noehl N, Endres SP, Heldwein W, Loeschke K, Fricke H. Antinuclear autoantibodies in patients with inflammatory bowel disease. High prevalence in first-degree relatives. Dig Dis Sci 1997; 42:1593-1597.
27. Bansi DS, Lo S, Chapman RW, Fleming KA. Absence of antineutrophil cytoplasmic antibodies in relatives of UK patients with primary sclerosing cholangitis and ulcerative colitis. Eur J Gastroenterol Hepatol 1996; 8:111-116.
28. Folwaczny C, Noehl N, Tschop K, Endres SP, Heldwein W, Loeschke K, Fricke H. Goblet cell autoantibodies in patients with inflammatory bowel disease and their first-degree relatives. Gastroenterology 1997; 113:101-106.
29. Yang H, Vora DK, Targan SR, Toyoda H, Beaudet AL, Rotter JI. Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease. Gastroenterology 1995; 109:440-448.
30. Braun C, Zahn R, Martin K, Albert E, Folwaczny C. Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. Clin Immunol 2001; 101:357-360.
31. Walker LJ, Aldhous MC, Drummond HE, Smith BR, Nimmo ER, Arnott ID, Satsangi J. Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations. Clin Exp Immunol 2004; 135:490-496.
32. Franchimont D, Vermeire S, El Housni H, Pierik M, Van Steen K, Gustot T, et al. Deficient host-bacteria interactions in inflammatory bowel disease? The Toll-like receptor (TLR)-4 Asp299Gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 2004; 53:987-992.
33. Sandborn WJ, Landers CJ, Tremaine WJ, Targan SR. Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch-anal anastomosis. Am J Gastroenterol 1995; 90:740-747.
34. Fleshner PR, Vasiliauskas EA, Kam LY, Fleshner NE, Gaiennie J, Abreu-Martin MT, Targan SR. High level pennuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis. Gut 2001; 49:671-677.
35. Mow WS, Vasiliauskas EA, Lin YC, Fleshner PR, Papadakis KA, Taylor KD, et al. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology 2004; 126:414-424.
36. Forcione DG, Rosen MJ, Kisiel JB, Sands BE. Anti-Saccharomyces cerevisiae antibody (ASCA) positivity is associated with increased risk for early surgery in Crohn's disease. Gut 2004; 53:1117-1122.
37. Klebl FH, Bataille F, Bertea CR, Herfarth H, Hofstadter F, Scholmerich J, Rogler G. Association of perinuclear antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae antibodies with Vienna classification subtypes of Crohn's disease. Inflamm Bowel Dis 2003; 9:302-307.