Effect of concurrent administration of alendronate sodium and retinol on development of changes in histomorphometric parameters of bones induced by ovariectomy in rats

Polish Journal of Pharmacology

Volumn 56, Issue 5, 2004, Pages 571-579

  Pytlik, Maria ^a   Kaczmarczyk Sedlak, Ilona ^a   Śliwiński, Leszek ^a   Janiec, Waldemar ^a   Rymkiewicz, Igor ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Alendronate sodium; Bones; Osteoporosis; Ovariectomy; Rats; Retinol

Indexed keywords

ALENDRONIC ACID; ESTROGEN; RETINOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY MASS; BONE DEFECT; BONE MASS; BONE MINERAL; BONE REMODELING; CONTROLLED STUDY; CORTICAL BONE; DOSE RESPONSE; DRUG INHIBITION; EPIPHYSEAL CARTILAGE; EPIPHYSIS; ESTROGEN DEFICIENCY; FEEDING; FEMALE; FEMUR; LONG BONE; METAPHYSIS; MORPHOMETRICS; NONHUMAN; OSTEOID; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; PERIOSTEUM; RAT; TIBIA; TRABECULAR BONE; VERTEBRA; WEIGHT GAIN;

ALENDRONATE; ANIMALS; BONE REMODELING; CALCIFICATION, PHYSIOLOGIC; DRUG COMBINATIONS; ESTROGENS; FEMALE; FEMUR; INTUBATION, GASTROINTESTINAL; LUMBAR VERTEBRAE; OVARIECTOMY; RATS; RATS, WISTAR; TIBIA; VITAMIN A;

EID: 12344321032     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Barnes CD, Eltherington LG: Drug dosage in laboratory animals. A handbook. University of California Press, Berkeley, 1964.
2. Beauchesne MF, Miller PF: Etidronate and alendronate in the treatment of postmenopausal osteoporosis. Ann Pharmacother, 1999, 33, 584-599.
3. Chambon P: The retinoid signalling pathway: molecular and genetic analyses. Semin Cell Biol, 1994, 5, 115-125.
4. Feshanich D, Singh V, Willet WC, Colditz GA: Vitamin A intake and hip fractures among postmenopausal women. JAMA, 2002, 287, 47-54.
5. Fisher JE, Rogers MJ, Halasy JM, Luckman SE, Hughes DE, Masarachia PJ: Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro. Proc Natl Acad Sci USA, 1999, 96, 133-138.
6. Folwarczna J, Pytlik M, Janiec W: Effects of doxycycline on development of changes in histomorphometric parameters of bones induced by bilateral ovariectomy in rats. Pol J Pharmacol, 2003, 55, 433-441.
7. Frolik CA, Bryant HU, Black EC, Magee DE, Chanrasekhar S: Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: effects of raloxifene HCl, tamoxifen, estrogen and alendronate. Bone, 1996, 18, 621-627.
8. Frost HM, Jee WSS: On the rat model of human osteopenias and osteoporosis. Bone Miner, 1992, 18, 227-236.
9. Giguere V: Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signalling. Endocr Rev, 1994, 15, 61-79.
10. Giuliani N, Pedrazzoni M, Negri G, Passeri G, Impiccatore M, Girasole G: Bisphosphonates stimulate formation of osteoblast precursors and mineralized nodules in murine and human bone marrow cultures in vitro and promote early osteoblastogenesis in young and aged mice in vivo. Bone, 1998, 22, 455-461.
11. Gudas LJ: Retinoids and verterbrate development. J Biol Chem, 1994, 269, 15399-15402.
12. Harda H, Miki R, Masushige S, Kato S: Gene expression of retinoic acid receptors, retinoid-X receptors, and cellular retinol-binding protein I in bone and its regulation by vitamin A. Endocrinology, 1995, 136, 5329-5335.
13. Hough S, Avioli L: Effects of hypervitaminosis A on the bone and mineral metabolism of the rat. Endocrinology, 1988, 122, 2933-2939.
14. Kalu DN: The ovariectomized rat model of postmenopausal bone loss. Bone Miner, 1991, 15, 175-191.
15. Luckman SP, Hughes DE, Coxon FP, Graham R, Russell G, Rogers MJ: Nitrogen containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res, 1998, 13, 581-589.
16. Mangolas SC: Birth and death of bone cells: basic regulatory mechanisms and implications for the patogenesis and treatment of osteoporosis. Endocr Rev, 2000, 21, 115-137.
17. Melhus H, Michaelsson K, Kindmark A, Bergstrom R, Holmberg L, Mallmin H, Wolk A et al.: Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med, 1998, 129, 770-778.
18. Milch RA, Rall DP, Tobie JE: Bone localization of tetracyclines. J Natl Cancer Inst, 1957, 19, 87-93.
19. Milstone LM, Leachman SA: Do retinoids cause osteoporosis? In: Nutritional Aspects of Osteoporosis. Ed. Burchardt P, Dawson-Hughes B, Heaney RP, Academic Press, 2001, 285-293.
20. Moore T, Sharman IM.: Hypervitaminosis A combined with calcium deficiency in rats. Int J Vitam Nutr Res, 1979, 49, 14-20.
21. Podlewski JK, Chwalibogowska-Podlewska A.: Drugs of Modern Therapy. Split Trading. Fund. Büchner, Warszawa, 2001, 538-539.
22. Pytlik M: Effects of tibolone on the development of osteopenia induced by ovariectomy in rats. Pol J Pharmacol, 2002, 54, 35-43.
23. Pytlik M, Janiec W, Misiarz-Myrta M, Gubała I: Effects of simvastatin on the development of osteopenia caused by ovariectomy in rats. Pol J Pharmacol, 2003, 55, 63-71.
24. Pytlik M, Janice W, Śliwiński L, Folwarczna J, Nowińska B, Cegieła U, Kaczmarczyk-Sedlak I et al.: Effect of pamidronate disodium on the development of ovariectomy-induced changes in rats (Polish). Postepy Osteoartrol, 1999, 11, 48-58.
25. Rogers MJ, Gordon S, Benford HL, Coxon FP, Luckman SP, Monkkonen J, Frith JC: Cellular and molecular mechanisms of action of bisphosphonates. Cancer, 2000, 88, 2961-2978.
26. Rohde CM, Manatt M, Clagett-Dame U, DeLuca HF: Vitamin A antagonizes the action of vitamin D in rats. J Nutr, 1999, 129, 2246-2250.
27. Seedor JG, Quarticci HA, Thomson DD: The bisphosphonate alendronate inhibits bone loss due to ovariectomy in rats. J Bone Miner Res, 1999, 6, 339-346.
28. Sherrard DJ, Maloney NA: Single-dose tetracycline labeling for bone histomorphometry. Am J Clin Pathol, 1989, 91, 682-687.
29. Sowers MF, Wallace RB: Retinol, supplemental vitamin A and bone status. J Clin Epidemiol, 1990, 43, 693-699.
30. Suri S, Monkkonen J, Taskinen M, Pesonen J, Blank A, Phipps RJ, Rogers MJ: Nitrogen-containing bisphosphonates induce apoptosis of caco-2 cells in vitro by inhibiting the mewalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone, 2001, 29, 336-343.
31. Tanizawa T, Yamaguchi A, Uchiyama Y, Miyaura C, Ikeda T, Ejiri S, Nagai Y et al.: Reduction in bone formation and elevated bone resorption in ovariectomized rats with special reference to acute inflammation. Bone, 2000, 26, 43-53.
32. Tripp EJ, MacKay EH: Silver staining of bone prior to decalcification for quantitative determination osteoid in sections. Stain Technol, 1972, 47, 129-132.
33. 3 receptors. Cell, 1991, 65, 1255-1266.
34. Van Beek E, Pieterman E, Cohen L, Lowik C, Papapoulos S: Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun, 1999, 255, 491-494.
35. Waynforth HBW: Experimental and Surgical Technique in the Rat. Academic Press, London, 1980.
36. Werner EA, DeLuca F: Metabolism of a physiological amount of all-trans-retinol in the vitamin A-deficient rat. Arch Biochem Biophys, 2001, 393, 262-270.
37. Whiting SJ, Lemke B: Excess retinol intake may explain the high incidence of osteoporosis in northern Europe. Nutr Rev, 1999, 57, 192-195.
38. Wroński TJ, Yen CF: The ovariectomized rat as an animal model for postmenopausal bone loss. Cell Mater, 1991, 1, Suppl 69-74.
39. Yamazaki I, Yamaguchi H: Characteristics of an ovariectomized osteopenic rat model. J Bone Miner Res, 1989, 4, 13-22.