Determination of primary structure of a novel peptide from mistletoe and its antitumor activity

Yaoxue Xuebao

Volumn 39, Issue 10, 2004, Pages 813-817

  Kong, Jing Lin ^a   Du, Xiu Bao ^a   Fan, Chong Xu ^a   Xu, Jian Fu ^a   Zheng, Xiao Jun ^a  

^a Beijing Institute of Pharmaceutical Chemistry   (China)

Author keywords

Antitumor activity; Mistletoe; Primary structure; Viscotoxin; Viscotoxin B2

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; PEPTIDE DERIVATIVE; PLANT TOXIN; UNCLASSIFIED DRUG; VISCOTOXIN B2; VISCUM ALBUM EXTRACT;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CATION EXCHANGE; CONTROLLED STUDY; ENZYMATIC DEGRADATION; GEL FILTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; OSTEOBLAST; PLANT LEAF; PLANT STEM; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RAT; SARCOMA CELL; VISCUM ALBUM;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BONE NEOPLASMS; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; OSTEOSARCOMA; PEPTIDES; PLANT LEAVES; PLANT PROTEINS; PLANT STEMS; PLANTS, MEDICINAL; RATS; TUMOR CELLS, CULTURED; VISCUM;

EID: 12344301041     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Ochocka JR, Piotrowski A. Biologically active compounds from European mistletoe (Viscum album L.) [J]. Can J Plant Pathol, 2002,24(1):21-28.
2. Orru S, Scaloni A, Giannattasio M, et al. Amino acid sequence, S-S bridge arrangement and distribution in plant tissues of thionins from Viscum album [J]. Biol Chem, 1997,378(3):989-996.
3. Schrader G, Urech K, Grazi G, et al. Viscotoxin composition of the three European subspecied of Viscum album [J]. Planta Med, 1998,64(2):677-678.
4. Urech K, Schaller G, Ziska P, et al. Comparative study on the cytotoxic effect of viscotoxins and mistletoe lectin on tumor cells in culture [J]. Phytother Res, 1995,9 (1):49-55.
5. Wagner H, Jordan E, Feil B. Studies on the standardization of mistletoe preparations [J]. Oncology, 1986,43(Suppl 1):16-22.
6. Editorial office of Flora of the People's Republic of China. Flora of the People's Republic of China [M]. Vol 24. Beijing: Science Press, 1988. 147-158.
7. Kong DY, Luo SQ, Li HT, et al. Studies on the chemical components of Viscum coloratum III structure of viscumneoside III, V and VI [J]. Acta Pharm Sin, 1988,23(8):593-600.
8. Kong DY, Li HT, Luo SQ. Studies on the chemical components of Viscum coloratum VIII isolation and structure of 3-β-D-glucopuranosyloxy-butanol-2 [J]. Acta Pharm Sin, 1992,27(10):792-795.
9. Breddam K, Mekdal M. Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching [J]. Eur J Biochem, 1992,206 (1):103-107.