Bell's palsy and herpes simplex virus: Fact or mystery?

Otology and Neurotology

Volumn 26, Issue 1, 2005, Pages 109-113

  Linder, Thomas ^a,d   Bossart, Walter ^b   Bodmer, Daniel ^c  

^a Clin Otolaryngol Head/Neck Surg   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d Chefarzt Hals Nasen Ohrenklinik   (Switzerland)

Author keywords

Bell's palsy; Herpes simplex virus; Human herpes virus 6

Indexed keywords

GENOMIC DNA; VIRUS DNA;

AGAR GEL ELECTROPHORESIS; ARTICLE; BELL PALSY; CLINICAL ARTICLE; CONTROLLED STUDY; FACIAL NERVE; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN HERPESVIRUS 6; HUMAN TISSUE; LACRIMAL FLUID; MUSCLE BIOPSY; ORBICULARIS ORIS MUSCLE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VARICELLA ZOSTER VIRUS; VIRUS GENOME; VIRUS REACTIVATION;

BELL PALSY; BIOPSY; DNA, VIRAL; FACIAL MUSCLES; FACIAL NERVE; GENE EXPRESSION; GENICULATE GANGLION; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HERPESVIRUS 3, HUMAN; HERPESVIRUS 6, HUMAN; HUMANS; POLYMERASE CHAIN REACTION; TEARS; VESTIBULAR NERVE; VIRUS ACTIVATION;

EID: 12344287230     PISSN: 15317129     EISSN: None     Source Type: Journal    
DOI: 10.1097/00129492-200501000-00020     Document Type: Article

References (25)

1. Hadar T, Tovi F, Sidi J, et al. Specific IgG and IgA antibodies to herpes simplex virus and varicella zoster virus in acute peripheral facial palsy patients. J Med Virol 1983;12:237-45.
2. Mutsch M, Zhou W, Rhodes P, et al. Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy. N Engl J Med 2004;350:896-903.
3. Fisch U, Esslen E. Total intratemporal exposure of the facial nerve. Pathologic findings in Bell's palsy. Arch Otolaryngol 1972;95: 335-41.
4. Schwaber MK, Larsa T, Zealer D. MR1 in evaluation of facial paralysis. Otolaryngol Head Neck Surg 1990;103:672.
5. Sartoretti-Schefer S, Brandle P, Wichmann W. Intensity of MR contrast enhancement does not correspond to clinical and electroneurographic findings in acute inflammatory facial nerve palsy. AJNR Am J Neuroradiol 1996;17:1229-36.
6. Gacek RR, Gacek MR. Idiopathic facial paralysis (Bell's palsy). Otol Neurotol 2002;23:617-8.
7. McCormick DP. Herpes-simpex virus as a cause of Bell's palsy. Lancet 1972;1:937-9.
8. Devriese PP. Compression and ischemia of the facial nerve. Acta Otolaryngol 1974;77:108-18.
9. Abramsky O, Webb C, Teitelbaum, et al. Cellular immune response to peripheral nerve basic protein in idiopathic paralysis (Bell's palsy). J Neurol Sci 1975;26:13-20.
10. Addour KK, Bell DN, Hilsinger RL. Herpes simplex virus in idiopathic facial paralysis (Bell's palsy). JAMA 1975;233:527-30.
11. Takasu T, Furuta Y, Sato KC, et al. Detection of latent herpes simplex virus DNA and RNA in human geniculate ganglia by the polymerse chain reaction. Acta Otolaryngol 1992;112:1004-11.
12. Murakami S, Mizobuchi M, Nakashiro Y, et al. Bell's palsy and herpes simplex virus: identification of viral DNA in endoneurial fluid and muscle. Ann Intern Med 1996;124:27-30.
13. Aurelius E, Johansson B, Skoldenberg B, et al. Rapid diagnosis of herpes simplex encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid. Lancet 1991;337:189-92.
14. Aurelius E, Johansson B, Skoldenberg B, et al. Encephalitis in immunocompetent patients due to herpes simplex virus type 1 or 2 as determined by type-specific polymerase chain reaction and antibody assays of cerebrospinal fluid. J Med Virol 1993;39:179-86.
15. Yamamoto T, Mukai T, Kondo K, et al. Variation of DNA sequence in immediate-early gene of human herpesvirus 6 and variant identification by PCR. J Clin Microbiol 1994;32:473-6.
16. Maeda T, Okuno T, Hayashi K, et al. Abortion in human herpesvirus 6 DNA positive pregnant woman. Pediatr Infect Dis J 1997; 16:1176-7.
17. Vrabec JT, Payne DA. Prevalence of herpesviruses in cranial nerve ganglia. Acta Otolaryngol 2001;121:831-5.
18. Gacek RR. On the duality of the facial nerve ganglion. Laryngoscope 1998;108:1077-86.
19. Palva T, Hortling L, Ylikoski J, et al. Viral culture and electron microscopy of ganglion cells in Meniere's disease and Bell's palsy. Acta Otolaryngol 1978;86:269-75.
20. Mulkens PS, Bleeker JD, Schroder FP. Acute facial paralysis: a virological study. Clin Otolaryngol 1980;5:303-10.
21. Weber E. Schemata der Leitungsbahnen des Menschen. Heidelberg, Germany: Springer Press, 1999.
22. Pitkäranta A, Piiparinen H, Mannonen L, et al. Detection of human herpesvirus 6 and varicella zoster virus in tear fluid of patients with Bell's palsy by PCR. J Clin Microbiol 2000;38:2753-5.
23. Abiko Y, Ikeda M, Hondo R. Secretion and dynamics of herpes simplex virus in tears and saliva of patients with Bell's palsy. Otol Neurotol 2002;23:779-83.
24. Furuta Y, Ohtani F, Chida E, et al. Herpes simplex virus type 1 reactivation and antiviral therapy in patients with acute peripheral facial palsy. Auris Nasus Larynx 2001;28:13-7.
25. Hato N, Matsumo S, Kisaki H, et al. Efficacy of early treatment of Bell's palsy with oral acyclovir and prednisolone. Otol Neurotol 2003;24:948-51.