A novel murine model of cerebral scedosporiosis: Lack of efficacy of amphotericin B

Journal of Antimicrobial Chemotherapy

Volumn 54, Issue 6, 2004, Pages 1092-1095

  Capilla, Javier ^a   Mayayo, Emilio ^a   Serena, Carolina ^a   Pastor, F Javier ^a   Guarro, Josep ^a  

^a FACULTAT DE MEDICINA I CIÈNCIES DE LA SALUT   (Spain)

Author keywords

Animal models; Brain infections; Scedosporium apiospermum

Indexed keywords

AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; CYCLOPHOSPHAMIDE; FLUOROURACIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFECTION; BRAIN REGION; COLONY FORMING UNIT; CONTROLLED STUDY; DOSE RESPONSE; HISTOPATHOLOGY; KIDNEY PARENCHYMA; MOUSE; MYCOSIS; NEUTROPENIA; NONHUMAN; RANK SUM TEST; SCEDOSPORIOSIS; SCEDOSPORIUM APIOSPERMUM; SURVIVAL TIME;

AMPHOTERICIN B; ANIMALS; ANTIFUNGAL AGENTS; BRAIN; BRAIN DISEASES; DISEASE MODELS, ANIMAL; HUMANS; LIPOSOMES; MADUROMYCOSIS; MALE; MICE; NEUTROPENIA; SCEDOSPORIUM; TREATMENT FAILURE;

EID: 12344280075     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh468     Document Type: Article

References (20)

1. Steinbach, W. J. & Perfect, J. R. (2003). Newer antifungal therapy for emerging fungal pathogens. International Journal of Infectious Diseases 7, 5-25.
2. Mellinghoff, I. K., Winston, D. J., Mukwaya, G. et al. (2002). Treatment of Scedosporium apiospermum brain abscesses with posaconazole. Clinical Infectious Diseases 34, 1648-50.
3. Muñoz, P., Marín, M., Tornero, P. et al. (2000). Successful outcome of Scedosporium apiospermum disseminated infection treated with voriconazole in a patient receiving corticosteroid therapy. Clinical Infectious Diseases 31, 1499-501.
4. Capilla, J., Serena, C., Pastor, F. J. et al. (2003). Efficacy of voriconazole in treatment of systemic scedosporlosis in neutropenic mice. Antimicrobial Agents and Chemotherapy 47, 3676-8.
5. Fortún, J., Martín-Dávila, P., Sánchez, M. A. et al. (2003). Voriconazole in the treatment of invasive mold infections in transplant recipients. European Journal of Clinical Microbiology and Infectious Diseases 22, 408-13.
6. Girmenia, C., Luzi, G., Monaco, M. et al. (1998). Use of voriconazole in treatment of Scedosporium apiospermum infection: case report. Journal of Clinical Microbiology 36, 1436-8.
7. Perfect, J. R., Marr, K. A., Walsh, T. J. et al. (2003). Voriconazole treatment for less-common emerging or refractory fungal infections. Clinical infectious Diseases 36, 1122-31.
8. Castiglioni, B., Sutton, D. A., Rinaldi, M. G. et al. (2002). Pseudallescheria boydii (anamorph Scedosporium apiospermum) infection in solid organ transplant recipients in a tertiary medical center and review of the literature. Medicine 81, 333-48.
9. Kowacs, P. A., Soares; Silvado, C. E., Monteiro de Almeida, S. et al. (2004). Infection of the CNS by Scedosporium apiospermum after near drowning. Report of a fatal case and analysis of its confounding factors. Journal of Clinical Pathology 57, 205-7.
10. Cano, J., Guarro, J., Mayayo, E. et al. (1992). Experimental infection with Scedosporium inflatum. Journal of Medical and Veterinary Mycology 30, 413-20.
11. González, G. M., Tijerina, R., Najvar, L. et al. (2000). Experimental murine model of disseminated Pseudallescheria infection. Medical Mycology 40, 243-8.
12. Blasi, E., Barluzzi, U., Mazolla, R. et al. (1992). Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization. Infection and Immunity 60, 3682-8.
13. Chiller, T. M., Capilla, J., Sobel, R. A. et al. (2002). Development of a murine model of cerebral aspergillosis. Journal of Infectious Diseases 186, 574-7.
14. Nesky, M. A., McDougal, E. C. & Peacock, J. E. (2000). Pseudallescheria boydii brain abscess successfully treated with voriconazole and surgical drainage: case report and literature review of central nervous system pseudallescheriasis. Clinical Infectious Diseases 31, 673-7.
15. Graybill, J. R. (2000). The role of murine models in the development of antifungal therapy for systemic mycoses. Drug Resistance Updates 3, 364-83.
16. Lutsar, I., Roffey, S. & Troke, P. (2003). Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients. Clinical Infectious Diseases 37 728-32.
17. Carrillo-Muñoz, A. J. & Guarro, J. (2001). In vitro activities of four novel triazoles against Scedosporium spp. Antimicrobial Agents and Chemotherapy 45, 2151-3.
18. Espinel-Ingroff, A., Kathleen, B. & Sheehan, D. J. (2001). In vitro activities of voriconazole and reference agents as determined by NCCLS methods: review of the literature. Mycopathologia 150 101-15.
19. Sugar, A. M. & Liu, X. P. (2000). Effect of grapefruit juice on serum voriconazole concentrations in the mouse. Medical Mycology 38, 209-12.
20. Liu, Y., Ryan, M. E., Lee, H. M. et al. (2002). A chemically modified tetracycline (CMT-3) is a new antifungal agent. Antimicrobial Agents and Chemotherapy 46, 1447-54.