Measurement of mitochondrial respiration in permeabilized murine neuroblastoma (N-2α) cells, a simple and rapid in situ assay to investigate mitochondrial toxins

Journal of Biochemical and Biophysical Methods

Volumn 62, Issue 1, 2005, Pages 25-40

  Steyn, Stefanus J ^a   Pieterse, Daniël J ^a   Mienie, Lodewyk J ^a   Van Der Schyf, Cornelis J ^a,b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Digitonin; Mitochondria; MPP+; MPTP; N 2 cells; Neurotoxins; Toxicity

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; DIGITONIN; NEUROTOXIN; TOXIN;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; ASSAY; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; ENCEPHALOMYOPATHY; ENVIRONMENT; EUKARYOTIC CELL; INHIBITION KINETICS; MEASUREMENT; METABOLITE; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; MITOCHONDRION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; SCREENING; SENSITIVITY ANALYSIS; TIME; TOXIN ANALYSIS;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 1-METHYL-4-PHENYLPYRIDINIUM; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE, TUMOR; CELL RESPIRATION; DIGITONIN; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MITOCHONDRIA; NEUROBLASTOMA; TOXICITY TESTS;

EUKARYOTA; GYMNOMYZA SAMOENSIS; MURINAE; PARKINSONIA;

EID: 12344259554     PISSN: 0165022X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbbm.2004.07.002     Document Type: Article

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