Monitoring of a pharmaceutical nanomilling process using grating light reflection spectroscopy

Applied Spectroscopy

Volumn 59, Issue 1, 2005, Pages 16-25

  Hamad, Mazen L ^a   Kailasam, Srividya ^a   Brodsky, Anatol M ^a   Han, Ronald ^b   Higgins, John P ^b   Thomas, Denise ^b   Reed, Robert A ^b   Burgess, Lloyd W ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

GLRS; Grating light reflectance spectroscopy; Nanomilling; Particle sizing; PCA; Principal components analysis; Process analysis

Indexed keywords

GRATING LIGHT REFLECTANCE SPECTROSCOPY; NANOMILLING; PARTICLE SIZING; PROCESS ANALYSIS;

ACOUSTOELECTRIC EFFECTS; COMMINUTION; DRUG PRODUCTS; ELECTROMAGNETIC WAVE DIFFRACTION; PARTICLE SIZE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; PROCESS CONTROL; REAL TIME SYSTEMS;

SPECTROSCOPIC ANALYSIS;

DRUG; NANOTUBE; NAPROXEN;

ALGORITHM; ARTICLE; CHEMISTRY; COLLOID; COMPARATIVE STUDY; DRUG FORMULATION; EVALUATION; MATERIALS; METHODOLOGY; PARTICLE SIZE; PHOTOMETRY; PRINCIPAL COMPONENT ANALYSIS; SPECTROSCOPY; TABLET; ULTRASTRUCTURE; VALIDATION STUDY;

ALGORITHMS; COLLOIDS; DRUG COMPOUNDING; MANUFACTURED MATERIALS; NANOTUBES; NAPROXEN; NEPHELOMETRY AND TURBIDIMETRY; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PRINCIPAL COMPONENT ANALYSIS; SPECTRUM ANALYSIS; TABLETS;

EID: 12344259518     PISSN: 00037028     EISSN: None     Source Type: Journal    
DOI: 10.1366/0003702052940521     Document Type: Article

References (25)

1. V. V. Dabhade, T. R. Rama Mohan, and P. Ramakrishnan, Appl. Surf. Sci. 182, 390 (2001).
2. I. Gianinoni, E. Golinelli, G. Melzi, S. Musazzi, U. Perini, and F. Trespidi, Opt. Laser Eng. 39, 141 (2003).
3. A. R. Heath, P. D. Fawell, P. A. Bahri, and J. D. Swift, Part. Syst. Char. 19, 84 (2002).
4. M. Bartlett and H. B. Jiang, AIChE J. 47, 60 (2001).
5. F. Scheffold, J. Dispersion Sci. Technol. 23, 591 (2002).
6. M. Z. Li, D. Wilkinson, and M. Schrodl, AIChE J. 48, 2492 (2002).
7. P. Mougin, D. Wilkinson, and K. J. Roberts, Cryst. Growth Des. 2, 227 (2002).
8. A. S. Dukhin, P. J. Goetz, T. H. Wines, and P. Somasundaran, Colloids Surf., A 173, 127 (2000).
9. A. S. Dukhin and P. J. Goetz, Colloids Surf., A 192, 267 (2001).
10. J. P. Higgins, S. M. Arrivo, G. Thurau, R. L. Green, W. Bowen, A. Lange, A. C. Templeton, D. L. Thomas, and R. A. Reed, Anal. Chem. 75, 1777 (2003).
11. S. L. Randall, A. M. Brodsky, L. W. Burgess, and R. L. Green, Rev. Quant. Nondestruct. Eval. 72, 1713 (2003).
12. S. R. Thurber, A. M. Brodsky. and L. W. Burgess, Appl. Spectrosc. 54, 1506 (2000).
13. B. B. Anderson, A. M. Brodsky, and L. W. Burgess, U.S. Patent 5,502,560 (1996); U.S. Patent 5,610,708 (1997).
14. B. B. Anderson, A. M. Brodsky, and L. W. Burgess, U.S. Patent 5,502,560 (1996); U.S. Patent 5,610,708 (1997).
15. A. M. Brodsky, L. W. Burgess, S. A. Smith, and P. G. Vahey, Anal. Chem. 72, 4428 (1999).
16. B. B. Anderson, A. M. Brodsky, and L. W. Burgess, Anal. Chem. 68, 1081 (1996).
17. B. B. Anderson, A. M. Brodsky, and L. W. Burgess, Langmuir 13, 4273 (1997).
18. B. B. Anderson, A. M. Brodsky, and L. W. Burgess, Phys. Rev. E 54, 912 (1996).
19. A. M. Brodsky, L. W. Burgess, and S. A. Smith, Appl. Spectrosc. 52, 332A (1998).
20. M. C. Hutley, Diffraction Gratings (Academic Press Inc., New York, London, 1982).
21. R. G. Newton, Scattering Theory of Waves and Particles (McGraw-Hill, New York, 1966), sec. 1.3.
22. H. C. Van de Hulst, Light Scattering by Small Particles (Dover Publications, Inc., New York, 1981).
23. J. V. Champion, G. H. Meeten, and M. Senior, J. Colloid Interface Sci. 72, 471 (1979).
24. A. Brodsky and L. Burgess, Int. J. Mod. Phys., B 17, 337 (2003).
25. K. R. Beebe, R. J. Pell, and M. B. Seasholtz, Chemometrics: A Practical Guide (John Wiley and Sons, Inc., New York, 1998), pp. 81-112.