Synthesis, physico-chemical properties and biological activity of 1-(4-fluorophenyl)-4-[3-(2-,3- and 4-alkyloxyphenylcarbamoyloxy)-2- hydroxypropyl] piperaziniumchlorides

Scientia Pharmaceutica

Volumn 72, Issue 4, 2004, Pages 283-291

  Malík, Ivan ^a   Sedlárová, Eva ^a   Csöllei, Jozef ^b   Račanská, Eva ^a   Čižmárik, Jozef ^a   Kurfürst, Pavel ^b  

^a Physics and Informatics   (Slovakia)

^b UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

Author keywords

Antiarrhythmic activity; Phenylcarbamic acid derivatives

Indexed keywords

ANTIARRHYTHMIC AGENT; OUABAIN; PIPERAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; INFRARED SPECTROMETRY; MASS SPECTROMETRY; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION;

EID: 12344258714     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.aut-04-24     Document Type: Article

References (8)

1. Pokorná R. Relationship of the Structure and Local Anaestetic Effect in the Group of Esters of Alkoxy-substituted Phenylcarbamic Acid. Čes. a Slov. Farm. 1998;47:14-20
2. Gombošová I, Valentová, J, Tumová I, Švec P. The Influence of carbamate local anesthetics on the occurrence of experimental gastric ulcers. Pharmazie 1993;48:212-15
3. Hroboňová K, Hatrík S, Lehotay J, Čižmárik J. Study of local anaesthetics, part 146: Correlation between local anaesthesia, coded structural information, and chromatographic properties for homologous series of alkoxysubstituted esters of phenylcarbamic acid using a neural network. Pharmazie 1999;1:44-7
4. Chalina E G, Charakova L, Staneva T D. Synthesis, antiarrhythmic and hypertensive activity of some novel 1,3-disubstituted ureas and phenyl N-substituted carbamates. Eur. J. Med. Chem. 1998;33:985-90
5. Dovolil J, Beneš L. Antiradical Activity of Some Antiulcer and Local-Anaesthetic Active Substances. Čes. slov. Farm. 2001;50:203-5
6. Waisser K, Dražková K, Čižmárik J, Kaustová J. Inluence of Lipophilicity on the Antimycobacterial Activity of the Hydrochlorides of Piperidinylethyl Esters of Ortho-Substituted Phenylcarbamic Acids. Sci. Pharm. 2004;72:43-9
7. Šeršeň F, Králová K, Macho V, New Findings about the Inhibitory Action of Phenylcarbamates and Phenylthiocarbamates on Photosynthetic Apparatus. Pest. Bioch. Phys. 2000; 68:113-8
8. Mlynárová R, Čelková H, Rač anská E. Preparation and Pharmacological Characteristics of Aryloxyaminopropanol Derivatives with an Assumed Cardiovascular Effect. Čes. a Slov. Farm. 1996;45:260-4