Explicit solutions for a class of indirect pharmacodynamic response models

Computer Methods and Programs in Biomedicine

Volumn 77, Issue 2, 2005, Pages 91-97

  Jordan, P ^a   Gieschke, R ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Explicit solution; Hypergeometric function 2F1; Indirect response model; NONMEM

Indexed keywords

BONE; COMPUTER SIMULATION; DRUG PRODUCTS; KINETIC THEORY; MATHEMATICAL MODELS; ORDINARY DIFFERENTIAL EQUATIONS; PARAMETER ESTIMATION; REDUCTION;

BONE TURNOVER; DRUG ACTIONS; PHARMACODYNAMIC RESPONSES; RESPONSE MODELS;

PHARMACODYNAMICS;

BIOLOGICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; IBANDRONIC ACID;

ARTICLE; AUTOMATION; BONE TURNOVER; COMPUTER PROGRAM; DRUG MECHANISM; DRUG POTENCY; GEOMETRY; KINETICS;

BONE AND BONES; BONE REMODELING; DIPHOSPHONATES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, BIOLOGICAL;

EID: 12344253072     PISSN: 01692607     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmpb.2004.02.002     Document Type: Article

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