Impact of congenital heart disease on cerebrovascular blood flow dynamics in the fetus

Ultrasound in Obstetrics and Gynecology

Volumn 25, Issue 1, 2005, Pages 32-36

  Kaltman, J R ^a   Di, H ^a   Tian, Z ^a   Rychik, J ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Cerebrovascular circulation; Congenital heart disease; Fetal echocardiography

Indexed keywords

ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; BRAIN MALFORMATION; BRAIN PERFUSION; BRAIN VASCULAR RESISTANCE; CONGENITAL HEART DISEASE; CONTROLLED STUDY; DIASTOLE; DOPPLER ECHOGRAPHY; FETUS; FETUS CIRCULATION; FETUS DEATH; GESTATIONAL AGE; HEART SURGERY; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MIDDLE CEREBRAL ARTERY; NEUROLOGIC DISEASE; NEUROLOGICAL COMPLICATION; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; SYSTOLE; UMBILICAL ARTERY;

BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; CROSS-SECTIONAL STUDIES; FETAL DISEASES; GESTATIONAL AGE; HEART DEFECTS, CONGENITAL; HUMANS; MIDDLE CEREBRAL ARTERY; PULSATILE FLOW; ULTRASONOGRAPHY, DOPPLER, PULSED; UMBILICAL ARTERIES; VASCULAR RESISTANCE;

EID: 12344252880     PISSN: 09607692     EISSN: None     Source Type: Journal    
DOI: 10.1002/uog.1785     Document Type: Article

References (25)

1. Newburger JW, Jonas RA, Wernovsky G, Wypij D, Mickey PR, Kuban KC, Farrell DM, Holmes GL, Helmers SL, Constantinou J, Carrazana E, Barlow JK, Walsh AZ, Lucius KC, Share JC, Wessel DL, Hanley FL, Mayer JE, Castaneda AR, Ware JH. A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. N Engl J Med 1993; 329: 1057-1064.
2. Bellinger DC, Wypij D, Kuban KC, Rappaport LA, Hickey RP, Wernovsky G, Jonas RA, Newburger JW. Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. Circulation 1999; 100: 526-532.
3. Mahle WT, Clancy RR, Moss EM, Gerdes M, Jobes DR, Wernovsky G. Neurodevelopmental outcome and lifestyle assessment in school-aged and adolescent children with hypoplastic left heart syndrome. Pediatrics 2000; 105: 1082-1089.
4. Mahle WT, Tavani F, Zimmerman RA, Nicolson SC, Galli KK, Gaynor JW, Clancy RR, Montenegro LM, Spray TL, Chiavacci RM, Wernovsky G, Kurth CD. An MRI study of neurological injury before and after congenital heart surgery. Circulation 2002; 106(Suppl 1): 109-114.
5. Van Houten JP, Rothman A, Bejar R. High incidence of cranial ultrasound abnormalities in full-term infants with congenital heart disease. Am J Perinatol 1996; 13: 47-53.
6. Glauser TA, Rorke LB, Weinberg PM, Clancy RR. Congenital brain anomalies associated with the hypoplastic left heart syndrome. Pediatrics 1990; 85: 984-990.
7. Limperopoulos C, Majnemer A, Shevell MI, Rosenblatt B, Rohlicek C, Tchervenkov C. Neurologic status of newborns with congenital heart defects before open heart surgery. Pediatrics 1999; 103: 402-408.
8. Ikle L, Hale K, Fashaw L, Boucek M, Rosenberg AA. Developmental outcome of patients with hypoplastic left heart syndrome treated with heart transplantation. J Pediatr 2003; 142: 20-25.
9. Wernovsky G, Newburger J. Neurologic and developmental morbidity in children with complex congenital heart disease. J Pediatr 2003; 142: 6-8.
10. Donofrio MT, Bremer YA, Schicken RM, Gennings C, Morton LD, Eidem BW, Cetta F, Falkensammer CB, Huhta JC, Kleinman CS. Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Pediatr Cardiol 2003; 24: 436-443.
11. Gosling RG, King DH. Ultrasound angiology. In Arteries and Veins, Marcus AW, Adamson L, (eds). Churchill Livingstone: Edinburgh, 1975; 61-98.
12. Wladimiroff JW, Tonge HM, Stewart PA. Doppler ultrasound assessment of cerebral blood flow in the human fetus. Br J Obstet Gynaecol 1986; 93: 471-475.
13. Gramellini D, Folli MC, Raboni S, Vadora E, Merialdi A. Cerebral-umbilical Doppler ratio a predictor of adverse perinatal outcome. Obstet Gynecol 1992; 79: 416-420.
14. Arduini D, Rizzo G. Normal values of pulsatility index from fetal vessels: a cross-sectional study on 1556 healthy fetuses. J Perinat Med 1990; 18: 165-172.
15. Wernovsky G, Stiles KM, Gauvreau K, Gentles TL, duPlessis AJ, Bellinger DC, Walsh AZ, Burnett J, Jonas RA, Mayer JE, Newburger JW. Cognitive development after the Fontan operation. Circulation 2000; 102: 883-889.
16. Goldberg CS, Schwartz EM, Brunberg JA, Mosca RS, Bove EL. Schork A, Stetz SP, Cheatham JP, Kulik TJ. Neurodevelopmetal outcome of patients after the Fontan operation: a comparison between children with hypoplastic left heart syndrome and other functional single ventricle lesions. J Pediatr 2000; 137: 646-652.
17. Cohn HE, Sacks EJ, Heymann MA, Rudolph AM. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol 1974; 120: 817-824.
18. Kjellmer I, Karlsson K, Olsson T, Rosen KG. Cerebral reactions during intrauterine asphyxia in the sheep. I. Circulation and oxygen consumption in the fetal brain. Pediatr Res 1974; 8: 50-57.
19. Reuss ML, Rudolph AM. Distribution and recirculation of umbilical and systemic venous blood flow in fetal lambs during hypoxia. J Dev Physiol 1980; 2: 71-84.
20. Vyas S, Nicolaides KH, Bower S, Campbell S. Middle cerebral artery flow velocity waveforms in fetal hypoxaemia. Br J Obstet Gynaecol 1990; 97: 797-803.
21. Wladimiroff JW, vd Wijngaard JA, Degani S, Noordam MJ, van Eyck J, Tonge HM. Cerebral and umbilical arterial blood flow velocity waveforms in normal and growth-retarded pregnancies. Obstet Gynecol 1987; 69: 705-709.
22. Scherjon SA, Smolders-DeHaas H, Kok JH, Zondervan HA. The 'brain-sparing' effect: antenatal cerebral Doppler findings in relation to neurologic outcome in very preterm infants. Am J Obstet Gynecol 1993; 169: 169-175.
23. Chan FY, Pun TC, Lam P, Lam C, Lee CP, Lam YH. Fetal cerebral Doppler studies as a predictor of perinatal outcome and subsequent neurologic handicap. Obstet Gynecol 1996; 87: 981-988.
24. Edelstone DI, Rudolp AM. Preferential streaming of ductus venosus blood to the brain and heart in fetal lambs. Am J Physiol 1979; 237: 724-729.
25. Meise C, Germer U, Gembruch U. Arterial Doppler ultrasound in 115 second- and third-trimester fetuses with congenital heart disease. Ultrasound Obstet Gynecol 2001; 17: 398-402.