Modalities of radiotherapy in small cell lung cancer: Thoracic radiotherapy and prophylactic cerebral irradiation;Modalités de la radiothérapie dans les carcinomes bronchiques à petites cellules: Radiothérapie thoracique et irradiation prophylactique cérébrale

Revue de Pneumologie Clinique

Volumn 60, Issue 5 II, 2004, Pages

  Le Pechoux C ^a   Dhermain, F ^a   Bretel, J J ^a   Laplanche, A ^a   Dunant, A ^a   Tarayre, M ^a   Ruffie P ^a   Le Chevalier, T ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Chemotherapy; Combined treatment; Limited stage; Prophylactic cerebral irradiation; Small cell cancers; Thoracic radiotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; IFOSFAMIDE; IRINOTECAN; PACLITAXEL; TOPOTECAN; VINCRISTINE;

BLEEDING; BRAIN RADIATION; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CARDIOTOXICITY; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; ESOPHAGITIS; ESOPHAGUS STENOSIS; EVALUATION; HEART FAILURE; HEART VENTRICLE FUNCTION; HUMAN; LUNG CANCER; LUNG FIBROSIS; LUNG SMALL CELL CANCER; META ANALYSIS; METASTASIS; MINIMAL RESIDUAL DISEASE; MUCOSA INFLAMMATION; NEPHROTOXICITY; NEUROTOXICITY; NEUTROPENIA; PERICARDITIS; RELAPSE; RISK ASSESSMENT; SIDE EFFECT; SURVIVAL TIME; THORAX RADIOGRAPHY; THROMBOCYTOPENIA; TREATMENT OUTCOME; VOMITING;

BRAIN NEOPLASMS; CARCINOMA, SMALL CELL; COMBINED MODALITY THERAPY; HUMANS; LUNG NEOPLASMS;

EID: 12344251925     PISSN: 07618417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (92)

1. Duchesne G, Cassoni A, Pera M. Radiosensitivity related to neuroendocrine and endodermal differentiation in lung carcinoma lines. Radiother Oncol 1988;13:153-61.
2. Einhorn LH, Fee WH, Farber MO, et al. Improved chemotherapy for small-cell undifferentiated lung cancer. JAMA 1976;235:1225-9.
3. Roswit B, Patno ME, Rapp R, et al. The survival of patients with inoperable lung cancer: a large-scale randomized study of radiation therapy versus placebo. Radiology 1968;90:688-97.
4. Le Péchoux C, Le Chevalier T, Arriagada R. Traitement des cancers bronchiques à petites cellules localisés au thorax. In: Milleron B, Depierre A, editors. Cancers bronchopulmonaires. Paris: 1998:359-72.
5. Pignon JP, Arriagada R, Ihde DC, et al. A meta-analysis of thoracic radiotherapy for small-cell lung cancer [see comments]. N Engl J Med 1992;327:1618-24.
6. Warde P, Payne D. Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis [see comments]. J Clin Oncol 1992;10:890-5.
7. Coy P, Hodson I, Payne DG et al. The effect of dose of thoracic irradiation on recurrence in patients with limited stage small cell lung cancer. Initial results of a Canadian Multicenter Randomized Trial. Int J Radiat Oncol Biol Phys 1988;14:219-26.
8. Armstrong JG, Burman C, Leibel S, et al. Three-dimensional conformal radiation therapy may improve the therapeutic ratio of high dose radiation therapy for lung cancer. Int J Radiat Oncol Biol Phys 1993;26:685-9.
9. Mornex F, Van Houtte P, Cosset JM. [Biological basis of combined chemo-radiotherapy. Applications to lung cancers]. Cancer Radiother 1997;1:29-41.
10. Wagner H, Jr. Thoracic irradiation of limited small cell lung cancer: have we defined optimal dose, time, and fractionation? Lung Cancer 1997;17(Suppl. 1):S137-48.
11. Withers HR. Biologic basis for altered fractionation schemes. Cancer 1985;55(Suppl.):2086-95.
12. Turrisi AT III, Glover DJ, Mason BA. A preliminary report: concurrent twice-daily radiotherapy plus platinum-etoposide chemotherapy for limited small cell lung cancer. Int J Radiat Oncol Biol Phys 1988;15:183-7.
13. Johnson BE. Concurrent approaches to combined chemotherapy and chest radiotherapy for the treatment of patients with limited stage small cell lung cancer. Lung Cancer 1994;10(Suppl. 1):S281-7.
14. Turrisi AT III, Kim K, Blum R, et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med 1999;340:265-71.
15. nd small-cell study. Br J Cancer 1981;44:611-7.
16. Bergsagel DE, Jenkin RD, Pringle JF, et al. Lung cancer: clinical trial of radiotherapy alone vs. radiotherapy plus cyclophosphamide. Cancer 1972;30:621-7.
17. Krauss S, Perez C, Lowenbraun S, et al. Combined modality treatment of localized small-cell lung carcinoma. A randomized prospective study of the Southeastern Cancer Study Group. Cancer Clin Trials 1980;3:297-305.
18. Sundstrom S, Bremnes RM, Kaasa S, et al. Norwegian Lung Cancer Study Group. Cisplatin and etoposide regimen is superior to cyclophosphamide, epirubicin, and vincristine regimen in small-cell lung cancer: results from a randomized phase III trial with 5 years' follow-up. J Clin Oncol 2002;20:4665-72.
19. Pujol JL, Daures JP, Riviere A, et al., Etoposide plus cisplatin with or without the combination of 4'-epidoxorubicin plus cyclophosphamide in treatment of extensive small-cell lung cancer: a French Federation of Cancer Institutes multicenter phase III randomized study. J Natl Cancer Inst 2001;21;93:300-8.
20. Thomas GA, Barrand MA, Stewart S, et al., Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridisation. Eur J Cancer 1994;30A:1705-9.
21. Osterlind K, Hansen M, Hirsch FR, et al. Combination chemotherapy of limited-stage small-cell lung cancer. A controlled trial on 221 patients comparing two alternating regimens. Ann Oncol 1991;2:41-6.
22. Arriagada R, Le Chevalier T, Pignon JP, et al. Initial chemotherapeutic doses and survival in patients with limited small-cell lung cancer. N Engl J Med 1993;329:1848-52.
23. Fox RM, Woods RL, Brodie GN, Tattersall MH. A randomized study: small cell anaplastic lung cancer treated by combination chemotherapy and adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 1980;6:1083-5.
24. Kies MS, Mira JG, Crowley JJ, et al. Multimodal therapy for limited small-cell lung cancer: a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced-field radiation in partial responders: a Southwest Oncology Group Study. J Clin Oncol 1987;5:592-600.
25. Souhami RL, Geddes DM, Spiro SG, et al. Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: a controlled trial. Br Med J (Clin Res Ed) 1984;288:1643-6.
26. Tubiana M, Arriagada R, Cosset JM. Sequencing of drugs and radiation. The integrated alternating regimen. Cancer 1985;55(9 Suppl.):2131-9.
27. Withers HR, Taylor JM, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 1988;27:131-46.
28. Murray N, Coy P, Pater JL, et al. Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1993;11:336-44.
29. Perry MC, Eaton WL, Propert KJ, et al. Chemotherapy with or without radiation therapy in limited small-cell carcinoma of the lung. N Engl J Med 1987;316:912-8.
30. Work E, Nielsen OS, Bentzen SM, et al. Randomized study of initial versus late chest irradiation combined with chemotherapy in limited-stage small-cell lung cancer. Aarhus Lung Cancer Group [see comments]. J Clin Oncol 1997;15:3030-7.
31. Jeremic B, Shibamoto Y, Acimovic L, Milisavljevic S. Initial versus delayed accelerated hyperfractionated radiation therapy and concurrent chemotherapy in limited small-cell lung cancer: a randomized study. J Clin Oncol 1997;15:893-900.
32. Fried DB, Morris DE, Hensing TA, et al. A Meta-analysis evaluating the timing of thoracic radiation therapy in combined modality therapy for limited-stage small cell lung cancer. Int J Radiat Oncol Biol Phys 2003;57:Abst 26.
33. Hugli A, Moro D, Mermillod B, et al. Phase II trial of upfront accelerated thoracic radiotherapy combined with chemotherapy and optional up-front prophylactic cranial irradiation in limited small-cell lung cancer. Groupe d'Oncologie Thoracique des Regions Alpines. J Clin Oncol 2000;18:1662-7.
34. Takada M, Fukuoka M, Furuse K, et al. Phase III study of concurrent versus sequential thoracic radiotherapy (TRT) in combination with cisplatin and etoposide for limited-stage small cell lung cancer: preliminary results of the Japan Clinical Oncology Group. Proceedings of the American Society of Clinical Oncology 1996;15:372.
35. Takada M, Fukuoka M, Kawahara M, et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104. J Clin Oncol 2002;20:3054-60.
36. Arriagada R, Le Chevalier T, Baldeyrou P, et al. Alternating radiotherapy and chemotherapy schedules in small cell lung cancer, limited disease. Int J Radiat Oncol Biol Phys 1985;11:1461-7.
37. Arriagada R, Kramar A, Le Chevalier T, de Cremoux H. Competing events determining relapse-free survival in limited small-cell lung carcinoma. The French Cancer Centers' Lung Group. J Clin Oncol 1992;10:447-51.
38. Lebeau B, Urban T, Brechot JM, et al. A randomized clinical trial comparing concurrent and alternating thoracic irradiation for patients with limited small cell lung carcinoma. "Petites Cellules" Group. Cancer 1999;86:1480-7.
39. Gregor A, Drings P, Burghouts J, et al. Randomized trial of alternating versus sequential radiotherapy/chemotherapy in limited disease patients with small cell lung cancer: a European Organizationfor Research and Treatment of Cancer Lung Cancer Cooperative Group Study. J Clin Oncol 1997;15:2840-9.
40. Bunn PA, Jr, Lichter AS, Makuch RW, et al. Chemotherapy alone or chemotherapy with chest radiation therapy in limited stage small cell lung cancer. A prospective, randomized trial. Ann Intern Med 1987;106:655-62.
41. Perry MC, Hemdon JE, III, Eaton WL, Green MR. Thoracic radiation therapy added to chemotherapy for small-cell lung cancer: an update of Cancer and Leukemia Group B Study 8083. J Clin Oncol 1998;16:2466-7.
42. Sloan JA, Bonner JA, Hillman SL, et al. A quality-adjusted reanalysis of a Phase III trial comparing once-daily thoracic radiation vs. twice-daily thoracic radiation in patients with limited-stage small-cell lung cancer. Int J Radiat Oncol Biol Phys 2002;52:371-81.
43. Bonner JA, Sloan JA, Shanahan TG, et al. Phase III comparison of twice-daily split-course irradiation versus once-daily irradiation for patients with limited stage small-cell lung carcinoma. J Clin Oncol 1999;17:2681-91.
44. Videtic GM, Fung K, Tomiak AT, et al. Using treatment interruptions to palliate the toxicity from concurrent chemoradiation for limited small cell lung cancer decreases survival and disease control. Lung Cancer 2001;33:249-58.
45. Mennecier B, Jacoulet P, Dubiez A, et al. Concurrent cisplatin/etoposide chemotherapy plus twice daily thoracic radiotherapy in limited stage small cell lung cancer: a phase II study. Lung Cancer 2000;27:137-43.
46. Choi NC, Hemdon JE, Rosenman J, et al. Phase I study to determine the maximum-tolerated dose of radiation in standard daily and hyperfractionated- accelerated twice-daily radiation schedules with concurrent chemotherapy for limited-stage small-cell lung cancer. J Clin Oncol 1998;16:3528-36.
47. Brown PD, Bonner JA, Foote RL, et al. Long-term results of a phase I/II study of high-dose thoracic radiotherapy with concomitant cisplatin and etoposide in limited stage small-cell lung cancer. Am J Clin Oncol 2001;24:556-61.
48. nd, Lyss AP, et al. 70 Gy thoracic radiotherapy is feasible concurrent with chemotherapy for limited-stage small-cell lung cancer: analysis of Cancer and Leukemia Group B study 39808. Int J Radiat Oncol Biol Phys 2004;59:460-8.
49. Bremnes RM, Sundstrom S, Vilsvik J, Aasebo U, Norwegian Lung Cancer Study Group. Multicenter phase II trial of paclitaxel, cisplatin, and etoposide with concurrent radiation for limited-stage small-cell lung cancer. J Clin Oncol 2001;19:3532-8.
50. Edelman MJ, Chansky K, Gaspar LE, et al. Phase II trial of cisplatin/etoposide and concurrent radiotherapy followed by paclitaxel/ carboplatin consolidation for limited small-cell lung cancer: Southwest Oncology Group 9713. J Clin Oncol 2004;22:127-32.
51. Glisson B, Scott C, Komaki R, et al. Cisplatin, ifosfamide, oral etoposide, and concurrent accelerated hyperfractionated thoracic radiation for patients with limited small-cell lung carcinoma: results of radiation therapy oncology group trial. J Clin Oncol 2000;18:2990-5.
52. Levitan N, Dowlati A, Shina D, et al. Multi-institutional phase I/II trial of paclitaxel, cisplatin, and etoposide with concurrent radiation for limited-stage small-cell lung carcinoma. J Clin Oncol 2000;18:1102-9.
53. Videtic GM, Stitt LW, Dar AR, et al. Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited-stage small-cell lung cancer is associated with decreased survival. J Clin Oncol 2003;21:1544-9.
54. Murray N, Grafton C, Shah A, et al. Abbreviated treatment for elderly, infirm, or noncompliant patients with limited-stage small-cell lung cancer. J Clin Oncol 1998;16:3323-8.
55. Weinmann M, Jeremic B, Bamberg M, Bokemeyer C. Treatment of lung cancer in elderly part II: small cell lung cancer. Lung Cancer 2003;40:1-16.
56. Roach M III, Gandara DR, Yuo HS, et al. Radiation pneumonitis following combined modality therapy for lung cancer: analysis of prognostic factors [see comments]. J Clin Oncol 1995;13:2606-12.
57. Momex F, Danhier S, Van Houtte P. [Non small-cell bronchial cancers: toxicity of the association radiotherapy-chemotherapy. Review of the literature]. Bull Cancer 1994;81:5-13.
58. Bunn PA Jr, Crowley J, Kelly K, et al. Chemoradiotherapy with or without granulocyte-macrophage colony-stimulating factor in the treatment of limited-stage small-cell lung cancer: a prospective phase III randomized study of the Southwest Oncology Group. J Clin Oncol 1995;13:1632-41.
59. Sagman U, Lishner M, Maki E, et al. Second primary malignancies following diagnosis of small-cell lung cancer [see comments]. J Clin Oncol 1992;10:1525-33.
60. Pedersen-Bjergaard J, Osterlind K, Hansen M, et al. Acute nonlymphocytic leukemia, preleukemia, and solid tumors following intensive chemotherapy of small cell carcinoma of the lung. Blood 1985;66:1393-7.
61. Komaki R. Prophylactic cranial irradiation for small cell carcinoma of the lung. Cancer Treat Symp 1985;2:35-9.
62. Arriagada R, Le Chevalier T, Borie F, et al. Prophylactic cranial irradiation for patients with small cell lung cancer in complete remission. J Natl Cancer Inst 1995;87:183-90.
63. Kristensen CA, Kristjansen PEG, Hansen HH. Systemic chemotherapy of brain metastases from small cell lung cancer. A review. J Clin Oncol 1992;10:1498-1502.
64. Le Péchoux C, Arriagada R. Prophylactic cranial irradiation in small cell lung cancer. An enduring controversy. Hematol Oncol Clin J Am 2004;18:355-72.
65. Aroney RS, Aisner J, Wesley MN, et al. Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma. Cancer Treat 1983;Rep 67:675-82.
66. Beiler DD, Kane RC, Bemath AM, Cashdollar MR. Low dose elective brain irradiation in small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 1979;5:941-5.
67. Cox JD, Petrovich Z, Paig C, Stanley K. Prophylactic cranial irradiation in patients with inoperable carcinoma of the lung. Preliminary report of a cooperative trial. Cancer 1978;42:1135-40.
68. Eagan RT, Frytak S, Lee RE, et al. A case for preplanned thoracic and prophylactic whole brain radiation therapy in limited small cell lung cancer. Cancer Clin Trials 1981;4:261-6.
69. Hansen HH, Dombernowsky P, Hirsch FR, et al. Prophylactic irradiation in bronchogenic small cell anaplastic carcinoma. A comparative trial of localized versus extensive radiotherapy including prophylactic brain irradiation in patients receiving combination chemotherapy. Cancer 1980;46:279-84.
70. Jackson DV Jr, Richards F, Cooper MR, et al. Prophylactic cranial irradiation in small cell carcinoma of the lung. A randomized study. JAMA 1983;237:2730-3.
71. Maurer LH, Tulloh M, Weiss RB, et al. A randomized combined modality trial in small cell carcinoma of the lung/ comparison of combination chemotheray-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation. Cancer 1980;45:30-9.
72. Niiranen A, Holsti P, Salmo M. Treatment of small cell lung cancer. Two-drug vs four-drug chemotherapy and loco-regional irradiation with or without prophylactic cranial irradiation. Acta Oncol 1989;28:501-5.
73. Seydel HG, Creech R, Pagano M, et al. Prophylactic versus no brain irradiation in regional small cell lung carcinoma. Am J Clin Oncol 1985;8:218-23.
74. Gregor A, Cull A, Stephens RJ, et al. Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: Results of a multicentre randomised trial. Eur J Cancer 1997;33:1752-8.
75. Laplanche A, Monnet I, Santos-Miranda JA, et al. Controlled clinical trial of prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Lung Cancer 1998;21:193-201.
76. Ohonoshi T, Ueoka H, Kawahara S, et al. Comparative study of prophylactic cranial irradiation in patients with small cell lung cancer achieving a complete response: a long-term follow-up result. Lung Cancer 1994;10:47-54.
77. Wagner HJ, Kim K, Turrisi A. A randomized phase III study of prophylactic cranial irradiation vs observation in patients with small cell lung cancer achieving a complete response: final report of an incomplete trial by the ECOG and RTOG. Proc Amer Soc Clin Oncol 1996;15:376.
78. Craig JB, Jackson DV, Moody D, et al. Prospective evaluation of changes in computerized cranial tomography (CCT) in patients with small cell carcinoma (SCLC) treated with chemotherapy and cranial irradiation. J Clin Oncol 1984;2:1151-6.
79. Johnson BE, Patronas N, Hayes W, et al. Neurologic, computed cranial tomographic, and magnetic resonance imaging abnormalities in patients with small cell lung cancer: further follow-up to 6- to 13-year survivors. J Clin Oncol 1990;8:48-56.
80. Laukkanen E, Klonoff H, Allan B, et al. The role of prophylactic brain irradiation in limited stage small cell lung cancer: clinical, neuropsychologic, and CT sequelae. Int J Radiat Oncol Biol Phys 1988;14:1109-18.
81. Lishner M, Feld R, Payne DG, et al. Late neurological complications after prophylactic cranial irradiation in patients with small-cell lung cancer: The Toronto Experience. J Clin Oncol 1990;8:215-21.
82. Ahles TA, Silberfarb PM, Herndon J, et al. Psychologic and neuropsychologic functionning of patients with limited small-cell lung cancer treated with chemotherapy and radiation therapy with or without warfarin: a study by the Cancer and Leukemia Group B. J Clin Oncol 1998;16:1954-60.
83. Van Oosterhout AGM, van de Pol M, ten Velde GPM, Twijnstra A. Neurologic disorders in 203 consecutive patients with small cell lung cancer. Results of a longitudinal study. Cancer 1996;77:1434-41.
84. Komaki R, Meyers CA, Shin DM, et al. Evaluation of cognitive function in patients with limited small cell lung cancer prior to and shortly following prophylactic cranial irradiation. Int J Radiat Oncol Biol Phys 1995;33:179-82.
85. Erlington GM, Murray NM, Spiro SG, Newsom-Davis J. Neurological paraneoplastic syndromes in patients with small cell lung cancer. A prospective survey of 150 patients. J Neurol Neurosurg Psychiatry 1991;54:764-7.
86. Hill R. Residual effects of cigarette smoking on cognitive performance in normal aging. Psychol Aging 1989;4:251-4.
87. Aupérin A, Arriagada R, Pignon JP, et al. Prophylactic cranial irradiation for patients with small cell lung cancer in complete remission: a meta-analysis of individual data from 987 patients. N Engl J Med 1999;341:476-84
88. Lee JS, Umsawasdi T, Barkley HT Jr, et al. Timing of elective brain irradiation: a critical factor for brain metastasis-free survival in small cell lung cancer. Int J Radiat Oncol Biol Phys 1987;13:697-704.
89. Perez CA, Krauss S, Bartolucci AA, et al., for the Southeastern Cancer Study Group. Thoracic and elective brain irradiation with concomitant or delayed multiagent chemotherpy in the treatment of localized small cell carcinoma of the lung. Cancer 1981;47:2407-13
90. Wolfson AH, Bains Y, Lu J, et al. Twice-daily prophylactic cranial irradiation for patients with limited disease small-cell lung cancer with complete response to chemotherapy and consolidative radiotherapy. Report of a single institutional phase II trial. Am J Clin Oncol 2001;24:290-5.
91. Suwinski R, Lee SP, Withers HR. Dose-response relationship for prophylactic cranial irradiation in small cell lung cancer. Int J Radiat Oncol Biol Phys 1998;40:797-806.
92. Le Péchoux C, for the Prophylactic Cranial Irradiation (PCI99). International Trial Group (why a new prophylactic cranial Irradiation trial in small cell lung cancer (SCLC)): from the meta-analysis on PCI in SCLC complete responders to an international trial on PCI dose. Lung Cancer 2000;29(suppl 1):159.