Induction of non-painful and painful intestinal sensations by hypertonic saline: A new human experimental model

European Journal of Pain

Volumn 7, Issue 1, 2003, Pages 81-91

  Drewes, Asbjørn M ^a,b   Babenko, Liudmila ^b   Birket Smith, Lene ^a   Funch Jensen, Peter ^c   Arendt Nielsen, Lars ^b  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Experimental; Gut; Pain; Saline; Sensation

Indexed keywords

HYPERTONIC SOLUTION; SODIUM CHLORIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; NERVE ENDING; NOCICEPTION; PAIN ASSESSMENT; PAIN THRESHOLD; PRIORITY JOURNAL; VISCERAL PAIN; VISUAL ANALOG SCALE;

ADULT; AFFERENT PATHWAYS; AGED; COLON; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; SALINE SOLUTION, HYPERTONIC; SENSATION; SENSORY THRESHOLDS;

EID: 12244311845     PISSN: 10903801     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1090-3801(02)00070-8     Document Type: Article

References (52)

1. Andersen OK, Gracely RH, Arendt-Nielsen L. Facilitation of the human nociceptive reflex by stimulation of A beta-fibres in a secondary hyperalgesic area sustained by nociceptive input from the primary hyperalgesic area. Acta Physiol Scand 1995;155:87-97.
2. Arendt-Nielsen L. Characteristics, detection, and modulation of laser-evoked vertex potentials. Acta Anaesthesiol Scand 1994; 101(Suppl.):7-44.
3. Arendt-Nielsen L. Induction and assessment of experimental pain from human skin, muscle, and viscera. In: Jensen TS, Turner JA, Wiesenfeld-Hallin Z, editors. Proceedings of the 8th World Congress of Pain, Progress in Pain Research and Management. Seattle: ISAP Press; 1997. p. 393-425.
4. Arendt-Nielsen L, Brennum J, Sindrup S, Bak P. Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system. Eur J Appl Physiol 1994;68:266-73.
5. Arendt-Nielsen L, Drewes AM, Hansen JB, Tage-Jensen U. Gut pain reactions in man: an experimental investigation using short and long duration transmucosal electrical stimulation. Pain 1997a;69:255-62.
6. Arendt-Nielsen L, Drewes AM, Hansen JB, Tage-Jensen U. Gut pain reactions in man: an experimental investigation using short and long duration transmucosal electrical stimulation. Pain 1997b;69:255-62.
7. Arendt-Nielsen L, Laursen RJ, Drewes AM. Referred pain as an indicator for neural plasticity. Prog Brain Res 2000;129:343-56.
8. Babenko V, Graven-Nielsen T, Svensson P, Drewes AM, Jensen TS, Arendt-Nielsen L. Experimental muscle pain induced by intramuscular injections of bradykinin, serotonin, and substance P. Eur J Pain 1999;3:93-102.
9. Bernstein LMBL. A clinical test for esophagitis. Gastroenterol 1958;34:760-81.
10. Bhoola K, Figueroa C, Worthy K. Bioregulation of kinins: Kallikreins, kininogens, and kininases. Pharmacol Rev 1992;44:1-80.
11. Bouhassira D, Sabate JM, Coffin B, Le Bars D, Willer JC, Jian R. Effects of rectal distensions on nociceptive flexion reflexes in humans. Am J Physiol 1998;275:G410-7.
12. Bouin M, Delvaux M, Blanc C, Lagier E, Delisle MB, Fioramonti J, et al. Intrarectal injection of glycerol induces hypersensitivity to rectal distension in healthy subjects without modifying rectal compliance. Eur J Gastroenterol Hepatol 2001;13:573-80.
13. Drewes AM, Arendt-Nielsen L, Jensen JH, Hansen JB, Krarup HB, Tage-Jensen U. Experimental pain in the stomach: a model based on electrical stimulation guided by gastroscopy. Gut 1997;41:753-7.
14. Drewes AM, Arendt-Nielsen L, Krarup HB, Hansen JB, Tage-Jensen U. Pain evoked by electrical stimulation of the prepyloric region of the stomach: cutaneous sensibility changes in the referred pain area. Pain Res Manage 1999a;4:131-7.
15. Drewes AM, Helweg-Larsen S, Petersen P, Brennum J, Andreasen A, Poulsen LH, et al. McGill Pain Questionnaire translated into Danish: experimental and clinical findings. Clin J Pain 1993;9:80-7.
16. Drewes AM, Nielsen KD, Arendt-Nielsen L, Birket-Smith L, Hansen LM. The effect of cutaneous and deep pain on the electroencephalogram during sleep - an experimental study. Sleep 1997;20:632-40.
17. Drewes AM, Petersen P, Rössel P, Gao C, Hansen JB, Arendt-Nielsen L. Sensitivity and distensibility of the rectum and sigmoid colon in patients with irritable bowel syndrome. Scand J Gastroenterol 2001;36:827-32.
18. Drewes AM, Petersen P, Qvist P, Nielsen J, Arendt-Nielsen L. An experimental pain model based on electric stimulations of the colon mucosa. Scand J Gastroenterol 1999b;34:765-71.
19. Drewes AM, Schipper K-P, Dimcevski G, Petersen P, Andersen OK, Gregersen H, et al. Multi-modal assessment of pain in the oesophagus - a new experimental model. Am J Physiol Gastrointest Liver Physiol 2002;283:95-103.
20. Fass R, Naliboff B, Higa L, Johnson C, Kodner A, Munakata J, et al. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998;115:1363-73.
21. Graven-Nielsen T. Sensory manifestations and sensory-motor interactions during experimental muscle pain in man (thesis). Aalborg University, Denmark; 1997.
22. Graven-Nielsen T, Arendt-Nielsen L, Svensson P, Jensen TS. Experimental muscle pain: a quantitative study of local and referred pain in humans following injection of hypertonic saline. J Musculoskel Pain 1997;5:49-69.
23. Graven-Nielsen T, McArdle A, Phoenix J, Arendt-Nielsen L, Jensen TS, Jackson MJ, et al. In: vivo model of muscle pain: quantification of intramuscular chemical, electrical, and pressure changes associated with saline-induced muscle pain in humans. Pain 1997;69:137-43.
24. Gregersen H. Standardization of barostat procedures. Dig Dis Sci 1998;43:1416-20.
25. Gregersen H, Barlow J, Thompson D. Development of a computercontrolled tensiometer for real-time measurements of tension in tubular organs. Neurogastroenterol Motil 1999;11:109-18.
26. Gregersen H, Kassab G. Biomechanics of the gastrointestinal tract. Neurogastroenterol Motil 1996;8:277-97.
27. Hardy JD, Wolf HG, Goodel H. Pain sensations and reactions. Baltimore: Williams and Wilkins; 1952.
28. Hu WH, Martin CJ, Talley NJ. Intraesophageal acid perfusion sensitizes the esophagus to mechanical distension: a Barostat study. Am J Gastroenterol 2000;95:2189-94.
29. Jänig W, Häbler H-J. Visceral-autonomic integration. In: Gebhart GF, editor. Visceral pain, progress in pain research and management. Seattle: IASP Press; 1995. p. 311-48.
30. Jänig W, Haupt-Schade P, Kohler W. Afferent innervation of the colon: the neurophysiological basis for visceral sensation and pain. In: Mayer EA, Raybould HE, editors. Basic and clinical aspects of chronic abdominal pain. Amsterdam: Elsevier; 1993. p. 71-86.
31. Karling P, Nyhlin H, Wiklund U, Sjoberg M, Olofsson BO, Bjerle P. Spectral analysis of heart rate variability in patients with irritable bowel syndrome. Scand J Gastroenterol 1998;33:572-6.
32. Lembo T, Munakata J, Mertz H, Niazi N, Kodner A, Nikas V, et al. Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 1994;107:1686-96.
33. Lim RK, Miller DG, Guzman F, Rodgers DW, Rogers RW, Wang SK, et al. Pain and analgesia evaluated by the intraperitoneal bradykinin-evoked pain method in man. Clin Pharmacol Ther 1967;8:521-42.
34. Longhurst JC. Chemosensitive abdominal visceral afferent. In: Gebhart GF, editor. Visceral pain. Seattle: IASP Press; 1995. p. 99-132.
35. Louvel D, Delvaux M, Staumont G, Camman F, Fioramonti J, Bueno L, et al. Intracolonic injection of glycerol: a model for abdominal pain in irritable bowel syndrome? Gastroenterology 1996;110:351-61.
36. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994;107:271-93.
37. Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain 1993;54:241-89.
38. Michaelis M, Vogel C, Blenk KH, Janig W. Algesics excite axotomised afferent nerve fibres within the first hours following nerve transection in rats. Pain 1997;72:347-54.
39. Munakata J, Naliboff B, Harraf F, Kodner A, Lembo T, Chang L, et al. Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology 1997;112:55-63.
40. Ness TJ, Gebhart GF. Visceral pain: a review of experimental studies. Pain 1990;41:167-234.
41. Ness TJ, Metcalf AM, Gebhart GF. A psychophysiological study in humans using phasic colonic distension as a noxious visceral stimulus. Pain 1990;43:377-86.
42. Rössel P, Drewes AM, Petersen P, Nielsen J, Arendt-Nielsen L. Pain produced by electric stimulation of the rectum in patients with irritable bowel syndrome: further evidence of visceral hyperalgesia. Scand J Gastroenterol 1999;34:1001-6.
43. Sarker S, Aziz Q, Woolf CJ, Hobson AR, Thompson DG. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000;356:1154-9.
44. Sengupta JN, Gebhart GF. Gastrointestinal afferent fibers and sensation. In: Johnson L, editor. Physiology of the gastrointestinal tract. New York: Raven Press; 1994. p. 484-519.
45. Serra J, Azpiroz F, Malagelada JR. Perception and reflex responses to intestinal distention in humans are modified by simultaneous or previous stimulation. Gastroenterology 1995;109:1742-9.
46. Su X, Gebhart GF. Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J Neurophysiol 1998;80:2632-44.
47. Svendsen O, Edwards CN, Rasmussen AD. Hypertonic saline: study on muscle tissue toxicity in erythrocytes, rat myocyte culture and in rabbits after intramuscular injection. In: Presented at the 2nd World Congress of the World Institute of Pain, Istanbul, Turkey, June 2001.
48. Svensson P. Effects of human jaw-muscle pain on somatosensory and motor function: experimental studies and clinical implications (thesis). Aalborg University, Aalborg, Denmark; 2000.
49. Tougas G, Spaziani R, Hollerbach S, Djuric V, Pang C, Upton AR, et al. Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain. Gut 2001;49:706-12.
50. van der Schaar PJ, Lamers CB, Masclee AA. The role of the barostat in human research and clinical practice. Scand J Gastroenterol 1999;34(Suppl. 230):52-63.
51. Whitehead WE, Delvaux M. Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. Dig Dis Sci 1997;42:223-41.
52. Wolf S, Wolf HG. Pain arising from the stomach and mechanisms underlying gastric symptoms. Assoc Res Nerv Men Dis 1993;43:289-301.