Individual human serum differs in the amount of antibodies with affinity for pig fetal ventral mesencephalic cells and the ability to lyse these cells by complement activation

Cell Transplantation

Volumn 13, Issue 6, 2004, Pages 631-637

  Koopmans, Jan ^a   De Haan, Aalzen ^b   Bruin, Elinda ^b   Van Der Gun, Ieneke ^b   Van Dijk, Henk ^c   Rozing, Jan ^b   De Leij, Lou ^b   Staal, Michiel ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Complement dependent cytotoxicity; Parkinson's disease; Porcine; Ventral mesencephalon; Xenotransplantation

Indexed keywords

DOPAMINE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

ANIMAL MODEL; ANTIBODY TITER; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BRAIN CELL; CELL TRANSPLANTATION; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; CYTOLYSIS; CYTOTOXICITY; FLOW CYTOMETRY; GRAFT SURVIVAL; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; IN VITRO STUDY; MESENCEPHALON; NONHUMAN; NORMAL HUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SWINE; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 12244310794     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000004783983503     Document Type: Article

References (24)

1. Barker, R. A.; Dunnett, S. B.; Richards, A. The rejection of neural xenotransplants: A role for antibodies. Transplantation 68:1091-1092; 1999.
2. Barker, R. A.; Ratcliffe, E.; McLaughlin, M.; Richards, A.; Dunnett, S. B. A role for complement in the rejection of porcine ventral mesencephalic xenografts in a rat model of Parkinson's disease. J. Neurosci. 20:3415-3424; 2000.
3. Björklund A.; Stenevi, U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 177:555-560; 1979.
4. Deacon, T.; Schumacher, J.; Dinsmore, J.; Thomas, C.; Palmer, P.; Kott, S.; Edge, A.; Penney, D.; Kassissieh, S.; Dempsey, P.; Isacson, O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat. Med. 3:350-353; 1997.
5. Deacon, T. W.; Pakzaban, P.; Burns, L. H.; Dinsmore, J.; Isacson, O. Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats. Exp. Neurol. 130:151-167; 1994.
6. Fink, J. S.; Schumacher, J. M.; Ellias, S. L.; Palmer, E. P.; Saint-Hilaire, M.; Shannon, K.; Penn, R.; Starr, P.; VanHorne, C.; Kott, H. S.; Dempsey, P. K.; Fischman, A. J.; Raineri, R.; Manhart, C.; Dinsmore, J.; Isacson, O. Porcine xenografts in Parkinson's disease and Huntington's disease patients: Preliminary results. Cell Transplant. 9:273-278; 2000.
7. Freed, C. R.; Breeze, R. E.; Fahn, S. Placebo surgery in trials of therapy for Parkinson's disease. N. Engl. J. Med. 342:353-354; 2000.
8. Freed, C. R.; Breeze, R. E.; Rosenberg, N. L.; Schneck, S. A.; Kriek, E.; Qi, J. X.; Lone, T.; Zhang, Y. B.; Snyder, J. A.; Wells, T. H.; et al. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. N. Engl. J. Med. 327:1549-1555; 1992.
9. Freeman, T. B.; Olanow, C. W.; Hauser, R. A.; Nauert, G. M.; Smith, D. A.; Borlongan, C. V.; Sanberg, P. R.; Holt, D. A.; Kordower, J. H.; Vingerhoets, F. J. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann. Neurol. 38:379-388; 1995.
10. Freeman, T. B.; Wojak, J. C.; Brandeis, L.; Michel, J. P.; Pearson, J.; Flamm, E. S. Cross-species intracerebral grafting of embryonic swine dopaminergic neurons. Prog. Brain Res. 78:473-477; 1988.
11. HogenEsch, R. I.; Koopmans, J.; Copray, J. C.; van Roon, W. M.; Kema, I.; Molenaar, G.; Go, K. G.; Staal, M. J. Fetal porcine ventral mesencephalon graft. Determination of the optimal gestational age for implantation in parkinsonian patients. Exp. Brain Res. 132:345-350; 2000.
12. HogenEsch, R. I.; Staal, M. J.; Kema, I. P.; Buys, C. H.; Go, K. G. Utility of fragmented human fetal tissue as a potential dopaminergic brain graft in Parkinson's disease. Stereotact. Fund. Neurosurg. 61:1-11; 1993.
13. Huffaker, T. K.; Boss, B. D.; Morgan, A. S.; Neff, N. T.; Strecker, R. E.; Spence, M. S.; Miao, R. Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease. Exp. Brain Res. 77:329-336; 1989.
14. Koopmans, J.; HogenEsch, I.; Copray, S.; Middel, B.; van Dijk, H.; Go, K. G.; Staal, M. Cryopreservation of porcine fetal ventral mesencephalic tissue for intrastriatal transplantation in Parkinson's disease. Cell Transplant. 10: 573-581; 2001.
15. Larsson, L. C.; Czech, K. A.; Widner, H.; Korsgren, O. Discordant neural tissue xenografts survive longer in immunoglobulin deficient mice. Transplantation 68:1153-1160; 1999.
16. Larsson, L. C.; Duan, W. M.; Widner, H. Discordant xenografts: Different outcome after mouse and rat neural tissue transplantation to guinea-pigs. Brain Res. Bull. 49: 367-376; 1999.
17. Molenaar, G. J.; HogenEsch, R. I.; Sprengers, M. E.; Staal, M. J. Ontogenesis of embryonic porcine ventral mesencephalon in the perspective of its potential use as a xenograft in Parkinson's disease. J. Comp. Neurol. 382: 19-28; 1997.
18. Pakzaban, P.; Isacson, O. Neural xenotransplantation: Reconstruction of neuronal circuitry across species barriers. Neuroscience 62:989-1001; 1994.
19. Peschanski, M.; Defer, G.; N'Guyen, J. P.; Ricolfi, F.; Monfort, J. C.; Remy, P.; Geny, C.; Samson, Y.; Hantraye, P.; Jeny, R. Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon. Brain 117:487-499; 1994.
20. Schaapherder, A. F.; Daha, M. R.; te, B. M.; van-der-Woude, F. J.; Gooszen, H. G. Antibody-dependent cell-mediated cytotoxicity against porcine endothelium induced by a majority of human sera. Transplantation 57: 1376-1382; 1994.
21. Schaapherder, A. F.; Wolvekamp, M. C.; te, B. M.; Bouwman, E.; Gooszen, H. G.; Daha, M. R. Porcine islet cells of Langerhans are destroyed by human complement and not by antibody-dependent cell-mediated mechanisms. Transplantation 62:29-33; 1996.
22. Sumitran, S.; Liu, J.; Czech, K. A.; Christensson, B.; Widner, H.; Holgersson, J. Human natural antibodies cytotoxic to pig embryonic brain cells recognize novel non-Galalphal,3Gal-based xenoantigens. Exp. Neurol. 159:347-361; 1999.
23. van Roon, W. M. C.; Copray, J. C. V. M.; HogenEsch, R. I.; Staal, M. J.; Go, K. G. Fetal porcine mesencephalon grafts: Dissection procedure and cellular characterization in culture. Rest. Neurol. Neurosci. 7:199-205; 1995.
24. Widner, H.; Tetrud, J.; Rehncrona, S.; Snow, B.; Brundin, P.; Gustavii, B.; Björklund, A.; Lindvall, O.; Langston, J. W. Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). N. Engl. J. Med. 327:1556-1563; 1992.