Noninvasive monitoring of local drug release using x-ray computed tomography: Optimization and in vitro/in vivo validation

Journal of Pharmaceutical Sciences

Volumn 92, Issue 2, 2003, Pages 289-296

  Szymanski Exner, Agata ^a   Stowe, Nicholas T ^b   Salem, Kyle ^a   Lazebnik, Roee ^a   Haaga, John R ^c   Wilson, David L ^a   Gao, Jinming ^a,c  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

Drug delivery devices; Iohexol; Noninvasive monitoring; X ray CT

Indexed keywords

CONTRAST MEDIUM; IOHEXOL;

ARTICLE; BIODEGRADABLE IMPLANT; COMPUTER ASSISTED TOMOGRAPHY; DRUG DELIVERY SYSTEM; DRUG RELEASE; NON INVASIVE MEASUREMENT; NONHUMAN; RABBIT; ULTRAVIOLET RADIATION;

EID: 12244310452     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10295     Document Type: Article

References (17)

1. Benet LZ, Kroetz DL, Sheiner LB. 1996. Pharmacokinetics: The dynamics of drug absorption, distribution, and elimination. In: Hardman JG, Limbird LE, editors. Goodman & Gilman's The pharmacological basis of therapeutics, 9th ed. New York: McGraw-Hill. pp 3-27.
2. Singh M, Waluch V. 2000. Physics and instrumentation for imaging in-vivo drug distribution. Adv Drug Del Rev 41(1):7-20.
3. Wolf W. 2000. Introduction and overview of non-invasive drug monitoring. Adv Drug Deliv Rev 41(1):1-5.
4. Bhatnagar A, Hustinx R, Alavi A. 2000. Nuclear imaging methods for non-invasive drug monitoring. Adv Drug Del Rev 41(1):41-54.
5. Taylor J. 2000. Evolution from empirical dynamic contrast-enhanced magnetic resonance imaging to pharmacokinetic MRI. Adv Drug Del Rev 41(1):91-110.
6. Saleem A. 2000. In vivo monitoring of drugs using radiotracer techniques. Adv Drug Del Rev 41(1): 21-39.
7. Griffiths JR, Glickson JD. 2000. Monitoring pharmacokinetics of anticancer drugs: Non-invasive investigation using magnetic resonance spectroscopy. Adv Drug Del Rev 41(1):75-89.
8. Dowsett DJ, Kenny PA, Johnston RE. 1998. The physics of diagnostic imaging. London: Chapman & Hall Medical. pp 107-127.
9. Bushberg JT, Seibert JA, Leidholdt EMJ, Boone JM. 1994. The essential physics of medical imaging. Baltimore: Williams & Wilkins. pp 239-290.
10. Curry TS, Dowdey JE, Murry RC. 1990. Christensen's physics of diagnostic radiology, 4th ed. Philadelphia: Lippincott Williams & Wilkins. pp 70-87.
11. Hubbell JH, Scofield JH. 1988. X-ray attenuation cross sections for energies 100 eV to 100 keV and elements Z = 1 to Z = 92. Atomic Data and Nucl Data Tables 38:1.
12. Qian F, Szymanski A, Gao J. 2001. Fabrication and characterization of controlled release poly(D,Llactide-co-glycolide) millirods. J Biomed Mater Res 55(4):512-522.
13. Lazebnik RS, Lancaster TL, Breen MS, Lewin JS, Wilson DL. 2001. Volume registration using needle paths and point landmarks for evaluation of interventional MRI treatments. IEEE Transact Med Imag, submitted.
14. Lazebnik RS, Lancaster TL, Breen MS, Nour SG, Lewin JS, Wilson DL. 2002. Volume registration of interventional MRI data using needle paths and point landmarks. Proceedings of SPIE Medical Imaging 2002: Visualization, display, and imageguided procedures. SPIE, Vol. 4681, pp 39-46, 2002.
15. Salem KA, Szymanski-Exner A, Lazebnik RE, Breen MS, Gao J, Wilson DL. 2002. X-ray computed tomography methods for in vivo evaluation of local drug release systems. IEEE-Transact Med Imag in press.
16. Brown SJ, Hayball MP, Coulden RAR. 2000. Impact of motion artifact on the measurement of coronary calcium score. Br J Radiol 73:956-962.
17. Lebwohl D, Canetta R. 1998. Clinical development of platinum complexes in cancer therapy: A historical perspective and an update. Eur J Cancer 34(10): 1522-1534.