Effects of age and exercise on physiological dead space during simulated dives at 2.8 ATA

Journal of Applied Physiology

Volumn 94, Issue 2, 2003, Pages 507-517

  Mummery, H J ^a   Stolp, B W ^a   Del Dear, G ^a   Doar, P O ^a   Natoli, M J ^a   Boso, A E ^a   Archibald, J D ^a   Hobbs, G W ^a   El Moalem, H E ^a   Moon, R E ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Aging; Arterial CO2; End tidal CO2; Hyperbaric; Hypercapnia; Pulmonary gas exchange

Indexed keywords

ADULT; AGED; AGING; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; BICYCLE ERGOMETER; CAPNOGRAPHY; CORRELATION ANALYSIS; END TIDAL CARBON DIOXIDE TENSION; EXERCISE; FEMALE; FORCED EXPIRATORY VOLUME; GAS DIFFUSION; HUMAN; HYPERBARISM; HYPERCAPNIA; LUNG DEAD SPACE; LUNG GAS EXCHANGE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SPIROMETRY;

EID: 12244294515     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00367.2002     Document Type: Article

References (57)

1. Agostoni E, Gurtner G, Torri G, and Rahn H. Respiratory mechanics during submersion and negative-pressure breathing. J Appl Physiol 21: 251-258, 1966.
2. 2 on ventilation and blood gases in patients with chronic obstructive pulmonary disease during acute respiratory failure. Am Rev Respir Dis 122: 747-754, 1980.
3. Becker HF, Polo O, McNamara SG, Berthon-Jones M, and Sullivan CE. Effect of different levels of hyperoxia on breathing in healthy subjects. J Appl Physiol 81: 1683-1690, 1996.
4. Bland JM and Altman DG. Measuring agreement in method comparison studies. Stat Methods Med Res 8: 135-160, 1999.
5. Cardus J, Burgos F, Diaz O, Roca J, Barbera JA, Marrades RM, Rodriguez-Roisin R, and Wagner PD. Increase in pulmonary ventilation-perfusion inequality with age in healthy individuals. Am J Respir Crit Care Med 156: 648-653, 1997.
6. Carlyle RF and Nichols G. Abnormal red cells in blood of men subjected to simulated dives. Lancet: 1114-1116, 1979.
7. Carlyle RF, Nichols G, Paciorek JA, Rowles PM, and Spencer N. Changes in morphology and carbonic anhydrase content of red blood cells from men subjected to simulated dives. J Physiol 292: 34P-35P, 1979.
8. Chick TW, Cagle TG, Vegas FA, Poliner JK, and Murata GH. The effect of aging on submaximal exercise performance and recovery. J Gerontol A Biol Sci Med Sci 46: B34-B38, 1991.
9. Christopherson SK and Hlastala MP. Pulmonary gas exchange during altered density gas breathing. J Appl Physiol 52: 221-225, 1982.
10. Clarke JR, Jaeger MJ, Zumrick JL, O'Brien R, and Spaur WH. Respiratory resistance from 1 to 46 ATA measured with the interrupter technique. J Appl Physiol 52: 549-555, 1982.
11. Cooper EA. Physiological deadspace in passive ventilation. Anaesthesia 22: 199-219, 1967.
12. Derks CM. Ventilation-perfusion distribution in young and old volunteers during mild exercise. Bull Eur Physiopath Respir 16: 145-154, 1980.
13. 2 during the respiratory cycle. J Appl Physiol 4: 535-548, 1952.
14. Fagraeus L and Linnarsson D. Maximal voluntary and exercise ventilation at high ambient air pressures. Forsvarmedicin 9: 275-278, 1973.
15. Florio JT, Morrison JB, and Butt WS. Breathing pattern and ventilatory response to carbon dioxide in divers. J Appl Physiol 46: 1076-1080, 1979.
16. 2 in trained underwater swimmers. J Appl Physiol 10: 203-206, 1957.
17. Hanson CW III, Marshall BE, Frasch HF, and Marshall C. Causes of hypercarbia with oxygen therapy in patients with chronic obstructive pulmonary disease. Crit Care Med 24: 23-28, 1996.
18. Hesser CM, Linnarsson D, and Fagraeus L. Pulmonary mechanics and work of breathing at maximal ventilation and raised air pressure. J Appl Physiol 50: 747-753, 1981.
19. Hickey DD, Norfleet WT, Pasche AJ, and Lundgren CEG. Respiratory function in the upright, working diver at 6.8 ATA (190 fsw). Undersea Biomed Res 14: 241-262, 1987.
20. 2 in healthy patients and in patients suffering from chronic bronchitis. Respiration 34: 332-340, 1977.
21. Janssens JP, Pache JC, and Nicod LP. Physiological changes in respiratory function associated with aging. Eur Respir J 13: 197-205, 1999.
22. CO2 difference during rebreathing in exercise. J Appl Physiol 27: 356-360, 1969.
23. CO2 during exercise. J Appl Physiol 47: 954-960, 1979.
24. 2 retention during hyperbaric exercise while breathing 40/60 nitrox. Undersea Hyperb Med 22: 339-346, 1995.
25. 2 at 1 ATA. Undersea Biomed Res 7: 17-26, 1980.
26. Knudson RJ, Clark DF, Kennedy TC, and Knudson DE. Effect of aging alone on mechanical properties of the normal adult human lung. J Appl Physiol 43: 1054-1062, 1977.
27. Lally DA, Zechman FW, and Trace RA. Ventilatory responses to exercise in divers and non-divers. Respir Physiol 20: 117-129, 1974.
28. 2 at pressure equivalent to 100 fsw (4 ata). Aerospace Med 44: 844-849, 1973.
29. Lanphier EH. Man in high pressures. In: Handbook of Physiology. Adaptation to the Environment. Washington, DC: Am. Physiol. Soc., 1964, sect. 4, chapt. 58, p. 893-909.
30. Lanphier EH and Bookspan J. Carbon dioxide retention. In: The Lung at Depth, edited by Miller JN. New York: Dekker, 1999, p. 222-226.
31. Lanphier EH and Camporesi EM. Respiration and exertion. In: The Physiology and Medicine of Diving (4th ed.), edited by Elliot DH. London: Saunders, 1993, p. 77-120.
32. 2. J Appl Physiol 17: 417-420, 1962.
33. O2 on measurement of ventilation/perfusion distribution in man at sea level. Ann NY Acad Sci 121: 797-808, 1965.
34. CO2 during air and oxygen breathing. J Appl Physiol 21: 1356-1362, 1966.
35. CO2 gradient during exercise in normal subjects and in patients with severe COPD. Chest 107: 1218-1224, 1995.
36. CO2 in hypoxic patients breathing oxygen. Crit Care Med 9: 32-37, 1981.
37. Lundgren CEG. Respiratory function during simulated wet dives. Undersea Biomed Res 11: 139-147, 1984.
38. Malmberg P, Hedenstrom H, and Fridriksson HV. Reference values for gas exchange during exercise in healthy non-smoking and smoking men. Bull Eur Physiopath Respir 23: 131-138, 1987,
39. 6 at 4 Ata. J Appl Physiol 33: 86-92, 1972.
40. Morrison JB, Florio JT, and Butt WS. Observations after loss of consciousness under water. Undersea Biomed Res 5: 179-187, 1978.
41. 2 tension difference in anesthetized man. J Appl Physiol 15: 383-389, 1960.
42. Poulin MJ, Cunningham DA, Paterson DH, Rechnitzer PA, Ecclestone NA, and Koval JJ. Ventilatory response to exercise in men and women 55 to 86 years of age. Am J Respir Crit Care Med 149: 408-415, 1994.
43. 2 tension and physiological dead space in normal man. J Appl Physiol 18: 284-288, 1963.
44. CO2 in men. J Appl Physiol 68: 1727-1731, 1990.
45. CO2 relative to predicted values during normal gas exchange. J Appl Physiol 43: 357-364, 1977.
46. Saltzman HA, Salzano JV, Blenkarn D, and Kylstra JA. Effects of pressure on ventilation and gas exchange in man. J Appl Physiol 30: 443-449, 1971.
47. Salzano JV, Camporesi EM, Stolp BW, and Moon RE. Physiological responses to exercise at 47 and 66 ATA. J Appl Physiol 57: 1055-1068, 1984.
48. Schaefer KE. Carbon dioxide effects under conditions of raised environmental pressure. In: The Physiology and Medicine of Diving and Compressed Air Work (2nd ed.), edited by Elliot DH. London: Bailliere Tindall, 1975.
49. Shepard RH, Campbell EJM, Martin HB, and Enns T. Factors affecting the pulmonary dead space as determined by single breath analysis. J Appl Physiol 11: 241-244, 1957.
50. Spaur WH, Raymond LW, Knott MM, Crothers JC, Braithwaite WR, Thalmann ED, and Uddin DF. Dyspnea in divers at 49.5 ATA: mechanical, not chemical in origin. Undersea Biomed Res 4: 183-198, 1977.
51. VanLiew HD. Mechanical and physical factors in lung function during work in dense environments. Undersea Biomed Res 10: 255-264, 1983.
52. Wagner PD, Dantzker D, Dueck R, Clausen J, and West JB. Ventilation-perfusion inequality in chronic obstructive pulmonary disease. J Clin Invest 59: 203-216, 1977.
53. 2. J Clin Invest 54: 54-68, 1974.
54. 2 retention with minimal symptoms but severe dysfunction during wet simulated dives to 6.8 atm abs. Undersea Biomed Res 17: 515-523, 1990.
55. Whipp BJ and Wasserman K. Alveolar-arterial gas tension differences during graded exercise. J Appl Physiol 27: 361-365, 1969.
56. CO2 during rest and exercise in older subjects. J Appl Physiol 83: 312-316, 1997.
57. Wood LDH, Bryan AC, Bau SK, Weng TR, and Levison H. Effect of increased gas density on pulmonary gas exchange in man. J Appl Physiol 41: 206-210, 1976.