Should patients with deep vein thrombosis alone be treated as those with concomitant asymptomatic pulmonary embolism? A prospective study

Thrombosis and Haemostasis

Volumn 88, Issue 6, 2002, Pages 938-942

  Monreal, Manuel ^a   Büller, Harry ^b   Was Lensing, Anthonie ^b   Bonet, Montserrat ^a   Roncales, Javier ^a   Muchart, Jordi ^a   Fraile, Manuel ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Anticoagulant therapy; Bleeding; Pulmonary embolism; Recurrences; Venous thrombosis

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; COUMARIN; DALTEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BLEEDING; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DISEASE CLASSIFICATION; DISEASE SEVERITY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DYSPNEA; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEART DISEASE; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; INFECTION; LUNG EMBOLISM; LUNG SCINTISCANNING; LUNG VENTILATION; MAJOR CLINICAL STUDY; MALE; MUSCLE BLEEDING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT DISEASE; RESPIRATORY TRACT DISEASE; RETROPERITONEAL HEMORRHAGE; RISK FACTOR; STROKE; THORAX PAIN;

EID: 12244289623     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613337     Document Type: Article

References (28)

1. Hyers TM, Agnelli G, Hull RD, Morris TA, Samama M, Tapson V, Weg JG. Antithrombotic therapy for venous thromboembolic disease. Chest 2001; 119: 176S-93S.
2. Vitoux JF, Aiach M, Roncato M, Fiessinger JN. Should thromboprophylactic dosage of low molecular weight heparin be adapted to patient's weight? Thromb Haemost 1988; 59: 120.
3. Kovacs MJ, Weir K, MacKinnon K, Keeney M, Brien WF, Cruickshank MK. Body weight does not predict for anti-Xa levels after fixed dose prophylaxis with enoxaparin after orthopedic surgery. Thromb Res 1998; 91: 137-42.
4. Kirchmaier CM, Wolf H, Schäfer H, Ehlers B, Breddin HK for the Certoparin Study Group. Efficacy of a low molecular weight heparin administered intravenously or subcutaneously in comparison with intravenous unfractionated heparin in the treatment of deep venous thrombosis. Int Angiol 1998; 17: 135-45.
5. Yee JY, Duffull SB. The effect of body weight on dalteparin pharmacokinetics. A preliminary study. Eur J Clin Pharmacol 2000; 56: 293-7.
6. Harenberg J, Schmidt JA, Koppenhagen K, Tolle A, Huisman MV, Büller HR. Fixed-dose, body weight-independent subcutaneous LMW heparin versus adjusted dose unfractionated intravenous heparin in the initial treatment of proximal venous thrombosis. EASTERN investigators. Thromb Haemost 2000; 83: 652-6.
7. Barrett JS, Gibiansky E, Hull RD, Planes A, Pentikis H, Hainer JW, Hua TA, Gastonguay M. Population pharmacodynamics in patients receiving tinzaparin for the prevention and treatment of deep vein thrombosis. Int J Clin Pharmacol Ther 2001; 39: 431-46.
8. Harenberg J, Huisman MV, Tolle AR, Breddin HK, Kirchmaier CM. Reduction in thrombus extension and clinical end points in patients after initial treatment for deep vein thrombosis with fixed-dose body weight-independent low molecular weight heparin certoparin. Semin Thromb Haemost 2001; 27: 513-8.
9. Douketis JD, Kearon C, Bates S, Duku EK, Ginsberg JS. Risk of fatal pulmonary embolism in patients with treated venous thromboembolism. JAMA 1998; 279: 458-62.
10. Douketis JD, Foster GA, Crowther MA, Prins MH, Ginsberg JS. Clinical risk factors and timing of recurrent venous thromboembolism during the initial 3 months of anticoagulant therapy. Arch Intern Med 2000; 160: 3431-6.
11. Heit JA, Silverstein MD, Mohr DN, Petterson TM, Lohse CM, O'Fallon WM, Melton LJ. The epidemiology of venous thromboembolism in the community. Thromb Haemost 2001; 86: 452-63.
12. Monreal M, Ruíz J, Salvador R, Morera J, Arias A. Recurrent pulmonary embolism. A prospective study. Chest 1989; 95: 976-9.
13. Monreal M, Lafoz E, Ruíz J, Callejas JM, Arias A. Recurrent pulmonary embolism in patients treated because of acute venous thromboembolism. A prospective study. Eur J Vasc Surg 1994; 8: 584-9.
14. Monreal M, Urrutia A, Martí S, Cuxart A, Roncales J. Platelet count and the risk of bleeding in hospitalized patients with venous thromboembolism starting anticoagulant therapy. Haemostasis 1997; 27: 91-8.
15. Monreal M, Montserrat E, Salvador R, Bechini J, Donoso L, Callejas JM, Foz M. Real-time ultrasound for diagnosis of symptomatic venous thrombosis and for screening of patients at risk: Correlation with ascending conventional venography. Angiology 1989; 40: 527-33.
16. Parker JA, Coleman RE, Siegel BA, Sostman HD, McKusick KA, Royal HD. Procedure guideline for lung scintigraphy. J Nucl Med 1996; 37: 1906-10.
17. Doyle J, Turpie AJ, Hirsh J, Best C, Kinch D, Levine MN, Gent M. Adjusted subcutaneous heparin or continuous intravenous heparin in patients with acute deep vein thrombosis. Ann Intern Med 1987; 107: 441-5.
18. Crowther M, Hirsh J. Low-molecular-weight heparin for the out-of-hospital treatment of venous thrombosis: Rationale and clinical results. Semin Thromb Haemost 1997; 23: 77-81.
19. Baron RM, Goldhaber SZ. Deep venous thrombosis: Outpatient management is now FDA approved. J Thromb Thrombolysis 1999; 7: 133-22.
20. Monreal M. Which DVT patients could be considered the best candidates for home therapy? Thromb Haemost 1999; 81: 996-7.
21. Huisman MV, Büller HR, Ten Cate JW, Van Royen EA, Vreeken J, Kersten MJ, Bakx R. Unexpected high prevalence of silent pulmonary embolism in patients with deep venous thrombosis. Chest 1989; 95: 498-502.
22. Moser KM, Fedullo PF, Litte John JK, Crawford R. Frequent asymptomatic pulmonary embolism in patients with deep venous thrombosis. JAMA 1994; 271: 223-225.
23. Meignan M, Rosso J, Gauthier H, Brunengo F, Claudel S, Sagnard L, D'Azemar P, Simonneau G, Charbonnier B. Systematic lung scans reveal a high frequency of silent pulmonary embolism in patients with proximal deep venous thrombosis. Arch Intern Med 2000; 160: 159-64.
24. Monreal M, Rey-Joly C, Ruíz J, Salvador R, Lafoz E, Viver E. Asymptomatic pulmonary embolism in patients with deep vein thrombosis. Is it useful to take a lung scan to rule out this condition? J Cardiovasc Surg 1989; 30: 104-7.
25. Monreal M, Lafoz E, Ruíz J, Valls R, Alastrue A. Upper-extremity deep venous thrombosis and pulmonary embolism. A prospective study. Chest 1991; 99: 280-3.
26. Monreal M, Raventos A, Lerma R, Ruíz J, Lafoz E, Alastrue A, Llamazares JF. Pulmonary embolism in patients with upper extremity DVT associated to venous central lines. A prospective study. Thromb Haemost 1994; 72: 548-50.
27. Monreal M, Ruíz J, Fraile M, Bonet M, Davant E, Muchart J, Vallejos V. Prospective study on the usefulness of lung scan in patients with deep vein thrombosis of the lower limbs. Thromb Haemost 2001; 85: 771-4.
28. Hirsh J, Raschke R, Warkentin TE, Dalen JE, Deykin D, Poller L. Heparin: Mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest 1995; 108 (Suppl): 258S-75S.