Experimental pain by ischaemic contractions compared with pain by intramuscular infusions of adenosine and hypertonic saline

European Journal of Pain

Volumn 7, Issue 1, 2003, Pages 93-102

  Graven Nielsen, Thomas ^a   Jansson, Ylva ^b   Segerdahl, Märta ^b   Kristensen, Jens D ^c   Mense, Siegfried ^d   Arendt Nielsen, Lars ^a   Sollevi, Alf ^b  

^a AALBORG UNIVERSITY   (Denmark)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d NONE

Author keywords

Adenosine; Experimental muscle pain; Ischaemic pain; Pressure algometry; Referred pain

Indexed keywords

ADENOSINE; HYPERTONIC SOLUTION; SODIUM CHLORIDE;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; MALE; MUSCLE CONTRACTION; MUSCLE ISCHEMIA; MYALGIA; NOCICEPTION; NORMAL HUMAN; PAIN ASSESSMENT; PRIORITY JOURNAL; VISUAL ANALOG SCALE;

EID: 12244283057     PISSN: 10903801     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1090-3801(02)00069-1     Document Type: Article

References (54)

1. Allsop P, Cheetham M, Brooks S, Hall GM, Williams C. Continuous intramuscular pH measurement during the recovery from brief, maximal exercise in man. Eur J Appl Physiol Occup Physiol 1990;59:465-70.
2. Arendt-Nielsen L. Induction and assessment of experimental pain from human skin, muscle, and viscera. In: Jensen TS, Turner JA, Wiesenfeld-Hallin Z, editors. Proceedings of the 8th World Congress on Pain. Seattle: IASP Press; 1997. p. 393-425.
3. Arendt-Nielsen L, Graven-Nielsen T, Svensson P, Jensen TS. Temporal summation in muscles and referred pain areas: an experimental human study. Muscle Nerve 1997;20:1311-3.
4. Babenko V, Graven-Nielsen T, Svensson P, Drewes AM, Jensen TS, Arendt-Nielsen L. Experimental human muscle pain and muscular hyperalgesia induced by combinations of serotonin and bradykinin. Pain 1999;82:1-8.
5. Bleehen T, Keele CA. Observations on the algogenic actions of adenosine compounds on the human blister base preparation. Pain 1977;3:367-77.
6. Boix F, Knardahl S. Biochemical factors related to ischemia increased bradykinin concentration in muscle tissue as measured by in vivo microdialysis. Pain in Europe III, European Federation of IASP Chapters (EFIC), Nice, France; 2000. p. 206 (Abstract).
7. Bonica JJ. General considerations of acute pain. In: Bonica JJ, editor. The management of pain, vol. 2. Philadelphia, London: Lea & Febiger; 1990. p. 159-79.
8. Burckhardt CS, Bjelle A. A Swedish version of the short-form McGill Pain Questionnaire. Scand J Rheumatol 1994;23:77-81.
9. Costa F, Sulur P, Angel M, Cavalcante J, Haile V, Christman B, Biaggioni I. Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. Hypertension 1999;33:1453-7.
10. Crea F, Gaspardone A, Versaci F, Tomai F, Perino M, Chiariello L, Gioffre PA. Algogenic effects of the proximal and distal intracoronary infusion of adenosine. Pathophysiologic implications on the mechanisms of ischemic cardiac pain. Cardiologia 1999;44:835-9.
11. Dowd E, McQueen DS, Chessell IP, Humphrey PP. Adenosine A1 receptor-mediated excitation of nociceptive afferents innervating the normal and arthritic rat knee joint. Br J Pharmacol 1998;125:1267-71.
12. Eriksson M, Englesson S, Niklasson F, Hartvig P. Effect of lignocaine and pH on propofol-induced pain. Br J Anaesth 1997;78:502-6.
13. Feinstein B, Langton JNK, Jameson RM, Schiller F. Experiments on pain referred from deep tissues. J Bone Joint Surg 1954;36:981-97.
14. Gaspardone A, Crea F, Tomai F, Versaci F, Iamele M, Gioffre G, Chiariello L, Gioffre PA. Muscular and cardiac adenosine-induced pain is mediated by A1 receptors. J Am Coll Cardiol 1995;25:251-7.
15. Graven-Nielsen T, Arendt-Nielsen L, Mense S. Thermosensitivity of muscle: high-intensity thermal stimulation of muscle tissue induces muscle pain in humans. J Physiol (Lond) 2002;540:647-56.
16. Graven-Nielsen T, Arendt-Nielsen L, Svensson P, Jensen TS. Experimental muscle pain: a quantitative study of local and referred pain in humans following injection of hypertonic saline. J Musculoskel Pain 1997a;5:49-69.
17. Graven-Nielsen T, Arendt-Nielsen L, Svensson P, Jensen TS. Stimulus-response functions in areas with experimentally induced referred muscle pain - a psychophysical study. Brain Res 1997b;744:121-8.
18. Graven-Nielsen T, Babenko V, Svensson P, Arendt-Nielsen L. Experimentally induced muscle pain induces hypoalgesia in heterotopic deep tissues, but not in homotopic deep tissues. Brain Res 1998a;787:203-10.
19. Graven-Nielsen T, Fenger-Gron LS, Svensson P, Steengaard-Pedersen K, Arendt-Nielsen L, Jensen TS. Quantification of deep and superficial sensibility in saline-induced muscle pain - a psychophysical study. Somatosens Mot Res 1998b;15:46-53.
20. Graven-Nielsen T, McArdle A, Phoenix J, Arendt-Nielsen L, Jensen TS, Jackson MJ, Edwards RHT. In vivo model of muscle pain: quantification of intramuscular chemical, electrical, and pressure changes associated with saline-induced muscle pain in humans. Pain 1997c;69:137-43.
21. Graven-Nielsen T, Mense S. The peripheral apparatus of muscle pain: evidence from animal and human studies. Clin J Pain 2001;17:2-10.
22. Graven-Nielsen T, Segerdahl M, Svensson P, Arendt-Nielsen L. Methods for induction and assessment of pain in humans with clinical and pharmacological examples. In: Kruger L, editor. Methods in pain research. Boca Raton: CRC Press; 2001. p. 264-304.
23. Harpuder K, Stein ID. Studies on the nature of pain arising from an ischemic limb. Am Heart J 1943;25:429-48.
24. Hellsten Y, Maclean D, Radegran G, Saltin B, Bangsbo J. Adenosine concentrations in the interstitium of resting and contracting human skeletal muscle. Circulation 1998;98:6-8.
25. Jensen K, Norup M. Experimental pain in human temporal muscle induced by hypertonic saline, potassium and acidity. Cephalalgia 1992;12:101-6.
26. Jonzon B, Sylvén C, Kaijser L. Theophylline decreases pain in the ischaemic forearm test. Cardiovasc Res 1989;23:807-9.
27. Klement W, Arndt JO. Adenosine does not evoke pain from venous and paravascular nociceptors in the human. Cardiovasc Res 1992;26:186-9.
28. Kosek E, Ekholm J. Modulation of pressure pain thresholds during and following isometric contraction. Pain 1995;61:481-6.
29. Lagerqvist B, Sylven C, Hedenstrom H, Waldenstrom A. Intravenous adenosine but not its first metabolite inosine provokes chest pain in healthy volunteers. J Cardiovasc Pharmacol 1990;16:173-6.
30. Lagerqvist B, Sylven C, Theodorsen E, Kaijser L, Helmius G, Waldenstrom A. Adenosine induced chest pain - a comparison between intracoronary bolus injection and steady state infusion. Cardiovasc Res 1992;26:810-4.
31. Laursen RJ, Graven-Nielsen T, Jensen TS, Arendt-Nielsen L. The effect of differential and complete nerve block on experimental muscle pain in humans. Muscle Nerve 1999;22:1564-70.
32. Lewis T. Pain in muscular ischemia. Arch Int Med 1932;49:713-27.
33. Martens MA, Backaert M, Vermaut G, Mulier JC. Chronic leg pain in athletes due to a recurrent compartment syndrome. Am J Sports Med 1984;12:148-51.
34. Martens MA, Moeyersoons JP. Acute and recurrent effort-related compartment syndrome in sports. Sports Med 1990;9:62-8.
35. Matsen FA. Compartmental syndromes. New Eng J Med 1979;300:1210-1.
36. Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain 1993;54:241-89.
37. Mense S, Simons DG. Muscle pain. In: Understanding its nature, diagnosis, and treatment. Philadelphia: Lippincott Williams & Wilkins; 2001.
38. Mense S, Stahnke M. Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat. J Physiol (Lond) 1983;342:383-97.
39. Mills KR, Newham DJ, Edwards RH. Force, contraction frequency and energy metabolism as determinants of ischaemic muscle pain. Pain 1982;14:149-54.
40. Myers DE, Shaikh Z, Zullo TG. Hypoalgesic effect of caffeine in experimental ischemic muscle contraction pain. Headache 1997;37:654-8.
41. Newham DJ, Mills KR. Muscles, tendons and ligaments. In: Wall PD, Melzack R, editors. Textbook of pain, vol. 4. Edinburgh: Churchill Livingstone; 1999. p. 517-38.
42. Pappagallo M, Gaspardone A, Tomai F, Iamele M, Crea F, Gioffre PA. Analgesic effect of bamiphylline on pain induced by intradermal injection of adenosine. Pain 1993;53:199-204.
43. Sadigh-Lindell B, Sylven C, Hagerman I, Berglund M, Terenius L, Franzen O, Eriksson BE. Oscillation of pain intensity during adenosine infusion. Relationship to β-endorphin and sympathetic tone. NeuroReport 2001;12:1571-5.
44. Sawynok J. Adenosine receptor activation and nociception. Eur J Pharmacol 1998;347:1-11.
45. Simone DA, Marchettini P, Caputi G, Ochoa JL. Identification of muscle afferents subserving sensation of deep pain in humans. J Neurophysiol 1994;72:883-9.
46. Stoll T, Huber E, Seifert B, Michel BA, Stucki G. Maximal isometric muscle strength: normative values and gender-specific relation to age. Clin Rheumatol 2000;19:105-13.
47. Svensson P, Arendt-Nielsen L, Nielsen H, Larsen JK. Effect of chronic and experimental jaw muscle pain on pain-pressure thresholds and stimulus-response curves. J Orofac Pain 1995;9:347-56.
48. Svensson P, Graven-Nielsen T, Arendt-Nielsen L. Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles. Pain 1998;74:93-100.
49. Sylven C, Jonzon B, Edlund A. Angina pectoris-like pain provoked by i.v. bolus of adenosine: relationship to coronary sinus blood flow, heart rate and blood pressure in healthy volunteers. Eur Heart J 1989;10:48-54.
50. Sylven C, Jonzon B, Fredholm BB, Kaijser L. Adenosine injection into the brachial artery produces ischaemia like pain or discomfort in the forearm. Cardiovasc Res 1988;22:674-8.
51. Vecchiet L, Galletti R, Giamberardino MA, Dragani L, Marini F. Modifications of cutaneous, subcutaneous and muscular sensory and pain thresholds after the induction of an experimental algogenic focus in the skeletal muscle. Clin J Pain 1988;4:55-9.
52. Vecchiet L, Giamberardino MA, Marini I. Immediate muscular pain from physical activity. In: Tiengo M, Eccles J, Cuello AC, Ottoson D, editors. Pain and mobility. New York: Raven Press; 1987. p. 193-218.
53. Wang K, Svensson P, Arendt-Nielsen L. Modulation of exteroceptive suppression periods in human jaw-closing muscles by local and remote experimental muscle pain. Pain 1999;82:253-62.
54. Witting N, Svensson P, Gottrup H, Arendt-Nielsen L, Jensen TS. Intramuscular and intradermal injection of capsaicin: a comparison of local and referred pain. Pain 2000;84:407-12.