Synthesis of antisense oligonucleotides conjugated to a multivalent carbohydrate cluster for cellular targeting

Bioconjugate Chemistry

Volumn 14, Issue 1, 2003, Pages 18-29

  Maier, Martin A ^a   Yannopoulos, Constantin G ^b   Mohamed, Nazim ^b   Roland, Arlene ^b   Fritz, Hans ^c   Mohan, V ^a   Just, George ^b   Manoharan, Muthiah ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c BECKMAN COULTER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATES; CONTROLLED DRUG DELIVERY; SYNTHESIS (CHEMICAL); TARGETED DRUG DELIVERY;

ANTISENSE; ANTISENSE OLIGONUCLEOTIDES; ASIALOGLYCOPROTEIN RECEPTORS; CARBOHYDRATE CLUSTERS; CARBOHYDRATE RECOGNITION; CARRIER-MEDIATED; CELLULAR UPTAKE; CELLULARS; IN-VIVO; THERAPEUTIC EFFICACY;

OLIGONUCLEOTIDES;

AMINOCAPROIC ACID; ANTISENSE OLIGONUCLEOTIDE; CARBOHYDRATE; CHOLANE DERIVATIVE; GALACTOSE; RESIN;

ARTICLE; BINDING AFFINITY; CONJUGATION; DRUG DELIVERY SYSTEM; LIVER PARENCHYMA; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; POROSITY; SOLID; SYNTHESIS;

EID: 12244274312     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc020028v     Document Type: Article

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