Affinities of gidazepam and its analogs for mitochondrial benzodiazepine receptors

Journal of Receptors and Signal Transduction

Volumn 22, Issue 1-4, 2002, Pages 411-420

  Korkhov, V M ^b   Tkachuk, N A ^b   Makan, S Yu ^a   Pavlovsky, V I ^a   Andronati, S A ^a  

^a A V BOGATSKY PHYSICO CHEMICAL INSTITUTE   (Ukraine)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; CHLORINE; GIDAZEPAM; LIGAND; RADIOLIGAND;

ADAPTATION; BINDING ASSAY; BINDING SITE; CELL FUNCTION; CONFERENCE PAPER; DRUG BINDING; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; LIPOPHILICITY; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY; STEROIDOGENESIS;

ANIMALS; ANTI-ANXIETY AGENTS; ANTI-ARRHYTHMIA AGENTS; BENZODIAZEPINES; BINDING SITES; BINDING, COMPETITIVE; BRAIN; DIAZEPAM; MALE; MITOCHONDRIA; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

RATTUS NORVEGICUS;

EID: 12244266444     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.1081/RRS-120014610     Document Type: Conference Paper

References (19)

1. Anholt, R.R.H.; De Souza, E.B.; Oster-Granite, M.L.; Snyder, S.H. Peripheral-Type Benzodiazepine Receptors: Autoradiographic Localization in Whole-Body Sections of Neonatal Rats. J. Pharmacol. Exp. Ther. 1985, 233, 517-526.
2. Barnard, E.A.; Skolnick, P.; Olsen, R.W.; Mohler, H.; Sieghart, G.; Biggio, G.; Braestrup, C.; Bateson, A.N.; Langer, S.Z. International Union of Pharmacology. XI. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Structure and Receptor Function. Pharmacol. Rev. 1998, 50, 291-313.
3. Anholt, R.R.H.; Pedersen, P.L.; De Souza, E.B.; Snyder, S.H. The Peripheral-Type Benzodiazepine Receptor: Localization to the Mitochondrial Outer Membrane. J. Biol. Chem. 1986, 261, 576-583.
4. Joseph-Liauzun, E.; Delmas, P.; Shire, D.; Ferrara, P. Topological Analysis of the Peripheral Benzodiazepine Receptor in Yeast Mitochondrial Membranes Supports a Five-Transmembrane Structure. J. Biol. Chem. 1998, 273, 2146-2152.
5. Gamier, M.; Dimchev, A.B.; Boujrad, N.; Price, J.M.; Musto, N.A.; Papadopoulos, V. In Vitro Reconstitution of a Functional Peripheral-Type Benzodiazepine Receptor from Mouse Leydig Tumor Cells. Mol. Pharmacol. 1994, 45, 201-211.
6. Galiegue, S.; Jbilo, O.; Combes, T; Bribes, E.; Carayon, P.; Le Fur, G.; Casellas, P. Cloning and Characterization of PRAX-1: A New Protein that Specifically Interacts with the Peripheral Benzodiazepine Receptor. J. Biol. Chem. 1999, 274, 2938-2952.
7. Joseph-Liauzun, E.; Farges, R.; Delmas, P.; Ferrara, P.; Loison, G. The Mr 18,000 Subunit if the Peripheral-Type Benzodiazepine Receptor Exhibits Both Benzodiazepine and Isoquinoline Carboxamide Binding Sites in the Absence of the Voltage-Dependent Anion Channel or of the Adenine Nucleotide Carrier. J. Biol. Chem. 1997, 272, 28102-28106.
8. Farges, R.; Joseph-Liauzun, E.; Shire, D.; Caput, D.; Le Fur, G.; Ferrara, P. Site-Directed Mutagenesis of the Peripheral Benzodiazepine Receptor: Identification of Amino Acids Implicated in the Binding Site of Ro5-4864. Mol. Pharmacol. 1994, 46, 1160-1167.
9. Cinone, N.; Holtje, H.-D.; Carotti, A. Development of a Unique 3D Interaction Model of Endogenous and Synthetic Peripheral Benzodiazepine Receptor Ligands. J. Comp.-Aided Mol. Des. 2000, 14, 753-768.
10. Anzini, M.; Cappelli, A.; Vomero, S.; Seeber, M.; Menziani, M.C.; Langer, T.; Hagen, B.; Manzoni, C.; Bourguignon, J.-J. Mapping and Fitting the Peripheral Benzodiazepine Receptor Binding Site by Carboxamide Derivatives. Comparison of Different Approaches to Quantitative Ligand-Receptor Interaction Modeling, J. Med. Chem. 2001, 44, 1134-1150.
11. Krueger, K.E.; Papadopoulos, V. Peripheral-Type Benzodiazepine Receptors Mediate Translocation of Cholesterol from Outer to Inner Mitochondrial Membranes in Adrenocortical Cells. J. Biol. Chem. 1990, 265, 15015-15022.
12. Moreno-Sanchez, R.; Hogne, B.A.; Bravo, C.; Newman, A.H.; Basile, A.S.; Chiang, P.K. Inhibition of Substrate Oxidation in Mitochondria by the Peripheral-Type Benzodiazepine Receptor Ligand AHN 086. Biochem. Pharmacol. 1991, 41, 1479-1484.
13. Cantor, E.H.; Kenessey, A.; Semenuk, G.; Spector, S. Interaction of Calcium Channel Blockers with Non-Neuronal Benzodiazepine Binding Sites. Proc. Natl. Acad. Sci. USA 1984, 81, 1549-1552.
14. Wang, J.K.T.; Morgan, J.I.; Spector, S. Benzodiazepines that Bind at Peripheral Sites Inhibit Cell Proliferation. Proc. Natl. Acad. Sci. USA 1984, 81, 753-756.
15. Gavish, M.; Laor, N.; Bidder, M.; Fischer, D.; Fonia, O.; Muller, U.; Roiss, A.; Wolmer, L.; Karp, L.; Weizman, R. Altered Platelet Peripheral-Type Benzodiazepine Receptor in Posttraumatic Stress Disorder. Neuropsychopharmacology 1996, 14, 181-186.
16. Gavish, M.; Bachman, I.; Shoukrun, R.; Katz, Y.; Veenman, L.; Weisinger, G.; Weizman, A. Enigma of the Peripheral Benzodiazepine Receptor. Pharmacol. Rev. 1999, 51, 629-650.
17. Andronati, S.A.; Bitensky, V.S.; Voronina, T.A.; Golovenko, N.M.; Garikov, N.M.; Zhuk, O.V.; Ivanets, I.I.; Kipervas, I.P.; Melnik, E.V.; Musichenko, A.P.; Neznamov, G.G.; Skibitsky, V.V. Gidazepam. Visnyk Psych. Zdorovya 1999, 3, 46-59.
18. Andronati, S.A.; Voronina, T.A.; Golovenko, N.M. Pharmacology of Gidazepam. In Gidazepam; Andronati, S.A., Ed.; Naukova Dumka: Kiev, 1992; 63-122.
19. Andronati, S.A.; Sava, V.M.; Makan, S.Yu.; Voronina, T.A.; Yakubovskaya, L.N.; Yavorsky, A.S.; Andronati, K.S. Affinity of Ethers of 3-Oxyphenazepam for Benzodiazepine Receptors. Neurophysiology 1994, 26, 262-265.