Inhibition of endogenous pancreatic enzyme secretion by oral pancreatic enzyme treatment

European Journal of Clinical Investigation

Volumn 33, Issue 1, 2003, Pages 65-69

  Walkowiak, Jaroslaw ^a   Witmanowski, H ^a   Strzykala, K ^a   Bychowiec, B ^a   Songin, T ^a   Borski, K ^a   Herzig, K H ^b  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Endogenous pancreatic secretion; Fecal chymotrypsin; Fecal elastase 1; Feedback mechanism; Pancreatic enzyme treatment

Indexed keywords

BIOLOGICAL MARKER; CHYMOTRYPSIN; FECAL ELASTASE 1; PANCREAS ENZYME; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHRONOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME THERAPY; FECES ANALYSIS; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PANCREAS FUNCTION; PANCREAS SECRETION; PRIORITY JOURNAL;

ADULT; CHYMOTRYPSIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; FEEDBACK, BIOCHEMICAL; FEMALE; HUMANS; MALE; PANCREAS; PANCREATIC ELASTASE; PANCREATIC FUNCTION TESTS; PANCREATIN;

EID: 12244262765     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2003.01077.x     Document Type: Article

References (43)

1. Green GM, Lyman RL. Feedback regulation of pancreatic enzyme secretion as a mechanism for trypsin inhibitor-induced hypersecretion in the rat. Proc Soc Exp Biol Medical 1972;140:6-12.
2. Ihse I, Lilja P, Lundquist I. Trypsin as a regulator of pancreatic secretion in the rat. Scand J Gastroenterol 1977;13:873-80.
3. Louie DS, May D, Miller P, Owyang C. Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am J Physiol 1986;250:252-9.
4. Fölsch UR, Cantor P, Wilms HM, Schafmayer A, Becker HD, Creutzfeldt W. Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rat. Gastroenterology 1987;92:449-58.
5. Rausch U, Weidenbach H, Adler G, Kern HF. Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor. II. Regulation of total protein and individual enzyme biosynthesis. Cell Tissue Res 1987;249:63-7.
6. Shiratori K, Chen YF, Chey W, Lee KY, Chang TM. Mechanism of increased exocrine pancreatic secretion in pancreatic juice-diverted rats. Gastroenterology 1986;91:1171-8.
7. Chernick SS, Lepovsky S, Chaikoff IL. A dietary factor regulating enzyme content of the pancreas: Changes induced in size and proteolytic activity of the chick pancreas by ingestion of raw soyabean meal. Am J Physiol 1986;250:252-9.
8. Corring T. Mechanisme de la secretion pancreatique exocrine chez le porc: Regulation par retro inhibition. Ann Biol Anim Biochim Biophys 1973;13:755-6.
9. Nustede R, Schmidt WE, Jager M, Stockmann F, Kohler H, Folsch UR et al. Gastrin-releasing peptide and CCK after intraduodenal inhibition of proteases in dogs. Int J Pancreatol 1994;15:209-14.
10. Herzig KH. Cholecystokinin- and secretin-releasing peptides in the intestine - A new regulatory interendocrine mechanism in the gastrointestinal tract. Regul Pept 1998;73:89-94.
11. Długosz J, Fölsch UR, Creutzfeldt W. Inhibition of intraduodenal trypsin does not stimulate exocrine pancreatic secretion in man. Digestion 1983;26:197-204.
12. Hotz J, Ho SB, Go VLW, DiMagno EP. Short-term inhibition of duodenal tryptic activity does not affect human pancreatic, biliary, or gastric function. J Laboratory Clin Med 1983;101:488-95.
13. Krawisz BR, Miller RJ, DiMagno EP, Go VLW. In the absence of nutrients, pancreatic-biliary secretions in the jejunum do not exert feedback control of human pancreatic or gastric function. J Laboratory Clin Med 1980;95:13-8.
14. Owyang C, Louie DS, Tatum D. Feedback regulation of pancreatic enzyme secretion: Suppression of cholecystokinin release by trypsin. J Clin Invest 1986;77:2042-7.
15. Slaff J, Jacobson D, Tillman CR, Curington C, Toskes P. Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology 1984;87:44-52.
16. Calam J, Bojarski JC, Springer CJ. Raw soya-bean flour increase cholecystokinin release in man. Br J Nutr 1987;58:175-9.
17. Mullenhoff A, Bozkurt T, Goke B, Koop I, Arnold R. Comparison of the effect of single and repeated administrations of a protease inhibitor (Camostate) on pancreatic secretion in man. Scand J Gastroenterol 1988;23:158-62.
18. Burton FR, Garvin PJ, Joshi SN. Human pancreatic graft fistula: Exocrine suppression by oral pancreatic enzymes. Transplantation 1989;47:888-91.
19. Mizutani S, Miyata M, Izukura M, Tanaka Y, Matsuda H. Role of bile and trypsin in the release of cholecystokinin in humans. Pancreas 1995;10:194-9.
20. Green GM, Nasset ES. Improtance of bile in the regulation of intraluminal proteolytic enzyme activities in the rat. Gastroenterology 1980;19:695-702.
21. Gomez G, Upp JR, Lluis F, Alexander RW, Poston GJ, Greeley GH et al. Regulation of the release of cholecystokinin by bile salts in dogs and humans. Gastroenterology 1988;94:1036-46.
22. Koop I, Fellgibel A, Koop H, Schafmayer A, Arnold R. Effect of cholestyramine on plasma cholecystokinin and pancreatic polypeptide levels, and exocrine pancreatic secretion. Eur J Clin Invest 1988;18:517-23.
23. Schafmayer A, Becker HD, Werner M, Fölsch UR, Creutzfeldt W. Plasma cholecystokinin levels in patients with chronic pancreatitis. Digestion 1985;32:136-9.
24. Slaff J, Wolfe M, Toskes P. Elevated fasting cholecystokinin levels in pancreatic exocrine impairment: Evidence to support feedback regulation. J Laboratory Clin Med 1985;105:282-5.
25. Funakoshi A, Nakano J, Shinozaki H, Tateishi K, Hamaoka T, Ibayashi H. High plasma cholecystokinin levels in patients with chronic pancreatitis having pain. Am J Gastroenterol 1986;81:1174-8.
26. Cantor P, Petronijevic L, Worning H. Plasma cholecystokinin concentrations in patients with advanced chronic pancreatitis. Pancreas 1986;1:488-93.
27. Bozkurt T, Adler G, Koop I, Koop H, Turmer W, Arnold R. Plasma CCK levels in patients with pancreatic insufficiency. Dig Dis Sci 1988;33:276-81.
28. Olsen O, Schaffalitzky de Muckadell OB, Cantor P, Erlanson-Albertsson C, Hansen CP, Worning H. Effect of trypsin on the hormonal regulation of the fat-stimulated human exocrine pancreas. Scand J Gastroenterol 1988;23:875-81.
29. Mössner J, Back T, Regner U, Fischbach W. Plasma cholecystokinin level in chronic pancreatitis. Z Gastroenterol 1989;27:401-5.
30. Etemad B, Whitcomb DC. Chronic pancreatitis: Diagnosis, classifications and new genetic developments. Gastroenterology 2001;120:682-707.
31. Scheefers-Borchel U, Scheffers H, Arnold R, Fischer P, Sziegoliet A. [Pankreatische elastase-1: Parameter für die chronische und akute pankreatitis.] Laboratory Med 1992;16:427-74.
32. Kaspar P, Möller G, Wahlefeld A. New photometric assay for chymotrypsin in stool. Clin Chem 1984;30:1753-7.
33. Walkowiak J. Fecal elastase-1 test - Clinical value in the assessment of exocrine pancreatic function in children. Eur J Pediatr, 2000;159:869-70.
34. Stein J, Jung M, Sziegoleit A, Zeuzem S, Caspary WF, Lembcke B. Immunoreactive elastase 1: Clinical evaluation of a new noninvasive test of pancreatic function. Clin Chem 1996;42:222-6.
35. Walkowiak J, Cichy WK, Herzig K-H. Comparison of fecal elastase-1 determination with the secretin-cholecystokinin test in patients with cystic fibrosis. Scand J Gastroenterol 1999;34:202-7.
36. Mössner J, Wresky HP, Kestel W, Zeeh J, Regner U, Fischbach W. Influence of treatment with pancreatic extracts on pancreatic enzyme secretion. Gut 1989;30:1143-9.
37. Mössner J, Stange JH, Ewald M, Kestel W, Fischbach W. Influence of exogenous application of pancreatic extracts on endogenous pancreatic enzyme secretion. Pancreas 1991;6:637-44.
38. Friess H, Kleeff J, Malfertheiner P, Müller MW, Homuth K, Büchler MW. Influence of high-dose pancreatic enzyme treatment on pancreatic function in healthy volunteers. Int J Pancreatol 1998;23:115-23.
39. Adler G, Reinshagen M, Koop I, Göke B, Schafmyer A, Rovati LC et al. Differential effects of atropine and a cholecystokinin receptor antagonist in pancreatic secretion. Gastroenterology 1989;96:1158-64.
40. Layer P, Jansen JBMJ, Cherian L, Lamers CBHW, Goebell H. Feedback regulation of human pancreatic secretion. Gastroenterology 1990;98:1311-9.
41. Friess H, Kleeff J, Isenmann R, Malfertheiner P, Büchler MW. Adaptation of the human pancreas to inhibition of luminal proteolytic activity. Gastroenterology 1998;115:388-96.
42. Owyang C, May D, Louie DS. Trypsin suppression of pancreatic enzyme secretion: Differential effect on cholecystokinin release and the enteropancreatic reflex. Gastroenterology 1986;91:637-43.
43. Jin HO, Song CW, Chang TM, Chey WY. Roles of gut hormones in negative-feedback regulation of pancreatic exocrine secretion in humans. Gastroenterology 1994;107:1828-34.