Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation

Bone Marrow Transplantation

Volumn 33, Issue 4, 2004, Pages 431-434

  Mori, T ^a   Mori, S ^b   Kanda, Y ^c   Yakushiji, K ^d   Mineishi, S ^e   Takaue, Y ^e   Gondo, H ^f   Harada, M ^f   Sakamaki, H ^b   Yajima, T ^a   Iwao, Y ^a   Hibi, T ^a   Okamoto, S ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NATIONAL CANCER CENTER HOSPITAL   (Japan)

^f KYUSHU UNIVERSITY   (Japan)

Author keywords

CMV antigenemia; Cytomegalovirus; Gastrointestinal disease; Hematopoietic stem cell transplantation; Real time PCR

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOMEGALOVIRUS ANTIGEN PP65; FLUDARABINE; GANCICLOVIR; GLUCOCORTICOID; METHOTREXATE; TACROLIMUS;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DIAGNOSTIC VALUE; DIARRHEA; DISEASE COURSE; EPIGASTRIC PAIN; FEMALE; GASTROINTESTINAL BIOPSY; GASTROINTESTINAL INFECTION; GASTROINTESTINAL SYMPTOM; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY; HUMAN; IMMUNOASSAY; LYMPH NODE IRRADIATION; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NAUSEA; NONHODGKIN LYMPHOMA; PATIENT MONITORING; PREDICTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECIPIENT; RETROSPECTIVE STUDY; T CELL LEUKEMIA; VIRUS LOAD; WHOLE BODY RADIATION;

ADULT; ANTIGENS, VIRAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; FEMALE; GASTROINTESTINAL DISEASES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS; VIRAL LOAD;

EID: 12144288318     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1704369     Document Type: Article

References (17)

1. Myers JD, Flournoy N, Thomas ED. Risk factors for cytomegalovirus infection after human marrow transplantation. J Infect Dis 1986; 153: 478-488.
2. Goodrich JM, Bowden RA, Fisher L et al. Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant. Ann Intern Med 1993; 118: 173-178.
3. Winston DJ, Bartoni K, Du Mond C et al. Ganciclovir prophylaxis of cytomegalovirus infection and disease in allogeneic bone marrow transplant recipients. Ann Intern Med 1993; 118: 179-184.
4. Boeckh M, Gooley TA, Myerson D et al. Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir vs ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study. Blood 1996; 88: 4063-4071.
5. Goodrich JM, Mori M, Gleaves CA et al. Early treatment with ganciclovir to prevent cytomegalovirus disease after allogeneic bone marrow transplantation. N Engl J Med 1991; 325: 1601-1607.
6. Schmidt GM, Horak D, Niland JC et al. A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants. N Engl J Med 1991; 324: 1005-1011.
7. Mori T, Okamoto S, Matsuoka S et al. Risk-adapted preemptive therapy for cytomegalovirus disease in patients undergoing allogeneic bone marrow transplantation. Bone Marrow Transplant 2000; 25: 765-769.
8. Kanda Y, Mineishi S, Saito T et al. Pre-emptive therapy against cytomegalovirus (CMV) disease guided by CMV antigenemia assay after allogeneic haematopoietic stem cell transplantation: a single-center experience in Japan. Bone Marrow Transplant 2001; 27: 437-444.
9. Gondo H, Minematsu T, Harada M et al. Cytomegalovirus (CMV) antigenaemia for rapid diagnosis and monitoring of CMV-associated disease after bone marrow transplantation. Br J Haematol 1994; 86: 130-137.
10. Kurihara T, Hayashi J, Matusoka T et al. HCMV pp65 antigenemia assay using indirect alkaline phosphatase staining method. Biomed Res 1995; 16: 125-129.
11. Heid CA, Stevens J, Livak KJ et al. Real time quantitative PCR. Genome Res 1996; 6: 986-994.
12. Mori T, Okamoto S, Watanabe R et al. Dose-adjusted preemptive therapy for cytomegalovirus disease based on real-time polymerase chain reaction after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2002; 29: 777-782.
13. Boeckh M, Boivin G. Quantitation of cytomegalovirus: methodologic aspects and clinical applications. Clin Microbiol Rev 1998; 11: 533-554.
14. Boeckh M, Gallez-Hawkins GM, Myerson D et al. Plasma polymerase chain reaction for cytomegalovirus DNA after allogeneic marrow transplantation: comparison with polymerase chain reaction using peripheral blood leukocytes. pp65 antigenemia, and viral culture. Transplantation 1997; 64: 108-113.
15. Ljungman P, Lore K, Aschan J et al. Use of a semiquantitative PCR for cytomegalovirus DNA as a basis for preemptive antiviral therapy in allogeneic bone marrow transplant patients. Bone Marrow Transplant 1996; 17: 583-587.
16. Einsele H, Ehninger G, Hebart H et al. Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation. Blood 1995; 86: 2815-2820.
17. Kanda Y, Chiba S, Suzuki T et al. Time course analysis of semi-quantitative PCR and antigenemia assay for prevention of cytomegalovirus disease after bone marrow transplantation. Br J Haematol 1998; 100: 222-225.