4-Hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one induces mitochondrial dysfunction and apoptosis upon its intracellular oxidation

Journal of Medicinal Chemistry

Volumn 48, Issue 1, 2005, Pages 192-199

  Chilin, Adriana ^a   Dodoni, Giuliano ^a   Frezza, Christian ^a   Guiotto, Adriano ^a   Barbieri, Vera ^a   Di Lisa, Fabio ^a   Canton, Marcella ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYMETHYL 1,6,8 TRIMETHYLFURO[2,3 H]QUINOLIN 2(1H) ONE; 4 METHYLPYRAZOLE; ALCOHOL DEHYDROGENASE; ANTINEOPLASTIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL VIABILITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYMATIC ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRION; OXIDATION;

ALCOHOL DEHYDROGENASE; AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; BIOCHEMISTRY; CHROMATIN; CYSTEINE PROTEINASE INHIBITORS; DARKNESS; FURANS; HUMANS; INTRACELLULAR MEMBRANES; JURKAT CELLS; MITOCHONDRIA; MOLECULAR BIOLOGY; OXIDATION-REDUCTION; PERMEABILITY; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12144280429     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0493919     Document Type: Article

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