Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells

Cellular and Molecular Life Sciences

Volumn 61, Issue 23, 2004, Pages 2991-2997

  Mastronicola, D ^a,c   Arcuri, E ^c   Arese, M ^a,b   Bacchi, A ^a,b   Mercadante, S ^d   Cardelli, P ^e   Citro, G ^c   Sarti, P ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^d LA MADDALENA CANCER CENTER   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Antinociceptive drug; Bioenergetics; Cytochrome oxidase; Nitrosative stress; Opioid responsiveness; Radicals

Indexed keywords

DESIPRAMINE; FENTANYL; METHADONE; MORPHINE; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; GLIOMA CELL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; RESPIRATORY CHAIN;

ADJUVANTS, ANESTHESIA; ANALGESICS, OPIOID; CELL LINE, TUMOR; ELECTRON TRANSPORT COMPLEX IV; FENTANYL; FREE RADICALS; GLIOMA; HUMANS; MEMBRANE POTENTIALS; METHADONE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MORPHINE; NARCOTICS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRITES; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; TIME FACTORS;

EID: 12144280247     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-004-4371-x     Document Type: Article

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