Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations

Chemical Research in Toxicology

Volumn 18, Issue 1, 2005, Pages 12-18

  Henderson, Paul T ^a,b   Neeley, William L ^a   Delaney, James C ^a   Gu, Feng ^a   Niles, Jacquine C ^a   Hah, Sang Soo ^b   Tannenbaum, Steven R ^a   Essigmann, John M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; BICARBONATE; DEOXYRIBONUCLEOSIDE; DNA POLYMERASE; MAGNESIUM; OXALURIC ACID; UNCLASSIFIED DRUG; URIC ACID DERIVATIVE;

ARTICLE; BACTERIOPHAGE; ESCHERICHIA COLI; GENE INSERTION; GENE MUTATION; GENE REPLICATION; GENETIC TRANSFECTION; GENOME ANALYSIS; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MUTAGENICITY; OXIDATION; POINT MUTATION; PROGENY;

DNA; DNA DAMAGE; ESCHERICHIA COLI; GUANINE; HYDROLYSIS; MUTAGENESIS; MUTAGENS; OXAMIC ACID; OXIDATION-REDUCTION; POINT MUTATION; SOS RESPONSE (GENETICS); TRANSFECTION; UREA;

ESCHERICHIA COLI; INSERTION SEQUENCES;

EID: 12144279499     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049757k     Document Type: Article

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