Potential anti-tumor promoting activity of lupane-type triterpenoids from the stem Bark of Glochidion zeylanicum and Phyllanthus flexuosus

Planta Medica

Volumn 70, Issue 12, 2004, Pages 1234-1236

  Tanaka, Reiko ^a,c   Kinouchi, Yoshitaka ^a   Wada, Shun Ichi ^a   Tokuda, Harukuni ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c Department of Medicinal Chemistry ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETULIN; EPSTEIN BARR VIRUS ANTIGEN; GLOCHIDIOL; GLOCHIDONE; GLOCHIDONOL; GLOCHIDONYL ACETATE; LUP 20(29) ENE 1,3 DIONE; LUP 20(29) ENE 1BETA,3BETA DIOL; LUP 20(29) ENE 3BETA,24 DIACETATE; LUP 20(29) ENE 3BETA,24 DIOL; LUPEOL; PHORBOL 13 ACETATE 12 MYRISTATE; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BARK; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG ISOLATION; FEMALE; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; PHYLLANTHUS; PLANT STEM; SKIN CARCINOGENESIS; SKIN TUMOR;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS, VIRAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; FEMALE; HERPESVIRUS 4, HUMAN; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED ICR; PAPILLOMA; PHYLLANTHUS; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; SKIN NEOPLASMS; SPECIFIC PATHOGEN-FREE ORGANISMS; TETRADECANOYLPHORBOL ACETATE; TRITERPENES;

ANIMALIA; GLOCHIDION; HUMAN HERPESVIRUS 4;

EID: 11944252042     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-835858     Document Type: Article

References (8)

1. Matsunaga S, Tanaka R, Takaoka Y, In Y, Ishida T, Rarmani M, Ismail HBM. 26-nor-D: A-friedooleanane triterpenes from Phyllanthus watosonii. Phytochemistry 1993; 32: 165-70
2. Tanaka R, Matsunaga S. Triterpene dienols and other constituents from the bark of Phyllanthus flexuosus. Phytochemistry 1988; 27: 2273-7
3. Hui WH, Lee WK, Ng KK, Chan CK. The occurrence of triterpenoids and steroids in three Glochidion species. Phytochemistry 1970; 9: 1099-102
4. Tanaka R, Tabuse M, Matsunaga S. Triterpenes from the stem bark of Phyllanthus flexuosus. Phytochemistry 1988; 27: 3563-7
5. Tanaka R, Matsunaga S, Ishida T. Revised structure of trichadenic acid B, a stem bark constituent of Phyllanthus flexuosus. Tetrahedron Letters 1988; 29: 4751-4
6. Huang M-T, Smart R. C, Wong C-Q, Conney A. H. Inhibition effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol 13-acetate. Cancer Research 1988; 48: 5941-6
7. Ito Y, Kawanishi M, Harayama T, Takabayashi S. Combined effect of the extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells. Cancer Letters 1981; 12: 175-80
8. Tokuda H, Ohigashi H, Koshimizu K, Ito Y. Inhibitory effects of ursolic acid and oleanolic acid on skin tumor promotion 12-O-tetradecanoylphorbol-13- acetate. Cancer Letters 1986; 33: 279-85