Total synthesis of psorospermin

Tetrahedron Letters

Volumn 46, Issue 5, 2005, Pages 827-829

  Schwaebe, Michael K ^a   Moran, Terence J ^a   Whitten, Jeffrey P ^a  

^a Cylene Pharmaceuticals   (United States)

Author keywords

Anticancer agent; Asymmetric synthesis; Natural product; Psorospermin; Xanthone

Indexed keywords

ANTINEOPLASTIC AGENT; NATURAL PRODUCT; PSOROSPERMIN; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHIRALITY; DRUG SYNTHESIS;

EID: 11844302205     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.12.006     Document Type: Article

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14. Compound 1 was converted to the 5-methoxy compound for chiral LCMS by treatment of 1 with methyl iodide in the presence of potassium carbonate in acetone. The mixture was evaluated by normal phase chiral chromatography using the Waters 600 pump controller, 2687 dual wave detector and ZQ mass spectrometer. The mobile phase was an isocratic mixture of hexane/isopropanol/ 1,2-dichloroethane; 30:10:10 at a constant flow of 6.0 mL/min. The stationary phase was a Chirex (S)-VAL and DNAn 250 × 10.0 mm column by phenomenex. The temperature was kept constant at 30°C with a Waters 600 column heater
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16. + (11)
17. An authentic sample of 1 was obtained from the NCI via Laurence Hurley