Hemolytic uremic syndrome following prolonged gemcitabine therapy: Report of four cases from a single institution

Annals of Hematology

Volumn 84, Issue 2, 2005, Pages 110-114

  Muller S ^a   Schutt P ^a   Bojko, P ^a   Nowrousian, M R ^a   Hense, J ^a   Seeber, S ^a   Moritz, Thomas ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Gemcitabine; Hemolysis; Hemolytic uremic syndrome; Microangiopathic thrombotic disease; Renal failure; Thrombocytopenia

Indexed keywords

BLEOMYCIN; CAPECITABINE; CARBOPLATIN; CARMUSTINE; CHLORAMBUCIL; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; HAPTOGLOBIN; HEMOGLOBIN; IFOSFAMIDE; LACTATE DEHYDROGENASE; MELPHALAN; METHOTREXATE; MITOMYCIN C; MITOXANTRONE; NAVELBINE; PREDNISONE; PROCARBAZINE; VINBLASTINE; VINCRISTINE;

ADULT; ANEMIA; ARTICLE; BILE DUCT CARCINOMA; BILIARY TRACT SURGERY; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER STAGING; CASE REPORT; DEATH; DRUG WITHDRAWAL; FATIGUE; FEMALE; GALLBLADDER CARCINOMA; HEMODIALYSIS; HEMOLYTIC UREMIC SYNDROME; HODGKIN DISEASE; HUMAN; INCIDENCE; KIDNEY FAILURE; LIVER METASTASIS; LIVER RESECTION; MALE; NONHODGKIN LYMPHOMA; PLASMAPHERESIS; PRIORITY JOURNAL; SPLENECTOMY; T CELL LYMPHOMA; THROMBOCYTOPENIA;

ADENOCARCINOMA; ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; DEOXYCYTIDINE; DISEASE PROGRESSION; FATAL OUTCOME; FEMALE; HEMOLYTIC-UREMIC SYNDROME; HUMANS; INCIDENCE; LYMPHOMA; MALE; MIDDLE AGED;

EID: 11844291977     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-004-0938-8     Document Type: Article

References (23)

1. Allford SL, Hunt BJ, Rose P, Machin SJ (2003) Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias. Br J Haematol 120:556-573 10.1046/j.1365-2141.2003.04049.x
2. Bell WR, Braine HG, Ness PM, Kickler TS (1991) Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients. N Engl J Med 325:398-403 1:STN:280:By6B1cjnsV0%3D
3. Borghardt EJ, Kirchertz EJ, Marten I, Fenchel K (1998) Protein A-immunoadsorption in chemotherapy associated hemolytic-uremic syndrome. Transfus Sci 19 [Suppl]:5-7 10.1016/S0955-3886(97)00097-0
4. Brodowicz T, Breiteneder S, Wiltschke C, Zielinski CC (1997) Gemcitabine-induced hemolytic uremic syndrome: A case report. J Natl Cancer Inst 89:1895-1896 10.1093/jnci/89.24.1895
5. Fung MC, Storniolo AM, Nguyen B, Arning M, Brookfield W, Vigil J (1999) A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy. Cancer 85:2023-2032 1:STN:280:DyaK1M3jslOmtA%3D%3D
6. Gasser C, Gautier E, Steck A, Siebenmann RE, Oechslin R (1955) Hemolytic-uremic syndrome: Bilateral kidney cortex necrosis in acute acquired hemolytic anemia, Schweiz Med Wochenschr 85:905-909 1:STN:280:BymC2czmtlI%3D
7. Gordon LI, Kwaan HC (1997) Cancer- and drug-associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Semin Hematol 34:140-147 1:STN:280:ByiB28zgtVw%3D
8. Guchelaar HJ, Richel DJ, van Knapen A (1996) Clinical, toxicological and pharmacological aspects of gemcitabine. Cancer Treat Rev 22:15-31 10.1016/S0305-7372(96)90014-6
9. Hui YF, Reitz J (1997) Gemcitabine: A cytidine analogue active against solid tumors. Am J Health Syst Pharm 54:162-170 (quiz 197-198) 1:CAS:528:DyaK2sXoslajuw%3D%3D
10. Lesesne JB, Rothschild N, Erickson B, Korec S, Sisk R, Keller J, Arbus M, Woolley PV, Chiazze L, Schein PS et al (1989) Cancer-associated hemolytic-uremic syndrome: Analysis of 85 cases from a national registry. J Clin Oncol 7:781-789 1:STN:280:BiaB3srntVU%3D
11. Melnyk AM, Solez K, Kjellstrand CM (1995) Adult hemolytic-uremic syndrome. A review of 37 cases. Arch Intern Med 155:2077-2084 10.1001/archinte.155.19.2077
12. Meyrier A, Becquemont L, Weill B, Callard P, Rainfray M (1991) Hemolytic-uremic syndrome with anticardiolipin antibodies revealing paraneoplastic systemic scleroderma. Nephron 59:493-496 1:STN:280:By2C3c%2Fis1c%3D
13. Palmisano J, Agraharkar M, Kaplan AA (1998) Successful treatment of cisplatin-induced hemolytic uremic syndrome with therapeutic plasma exchange. Am J Kidney Dis 32:314-317 1:STN:280:DyaK1cznt1ehtg%3D%3D
14. Remuzzi G, Ruggenenti P (1995) The hemolytic uremic syndrome. Kidney Int 48:2-19 1:STN:280:BymD383otFA%3D
15. Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, Spasoff RA (1991) Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med 325:393-397 1:STN:280:By6B1cjnsVw%3D
16. Schiebe ME, Hoffmann W, Belka C, Bamberg M (1998) Mitomycin C-related hemolytic uremic syndrome in cancer patients. Anticancer Drugs 9:433-435 1:CAS:528:DyaK1cXktFOju7Y%3D
17. Schieppati A, Ruggenenti P, Cornejo RP, Ferrario F, Gregorini G, Zucchelli P, Rossi E, Remuzzi G (1992) Renal function at hospital admission as a prognostic factor in adult hemolytic uremic syndrome. The Italian Registry of Haemolytic Uremic Syndrome. J Am Soc Nephrol 2:1640-1644 1:STN:280:By2A3crhslE%3D
18. Segonds A, Louradour N, Suc JM, Orfila C (1979) Postpartum hemolytic uremic syndrome: A study of three cases with a review of the literature. Clin Nephrol 12:229-242 1:STN:280:Bi%2BD28jot1E%3D
19. Serke S, Riess H, Oettle H, Huhn D (1999) Elevated reticulocyte count - a clue to the diagnosis of haemolytic-uraemic syndrome (HUS) associated with gemcitabine therapy for metastatic duodenal papillary carcinoma: A case report. Br J Cancer 79:1519-1521 10.1038/sj.bjc.6690242
20. Siegler RL (1995) The hemolytic uremic syndrome. Pediatr Clin North Am 42:1505-1529 1:STN:280:BymC3M%2FovVE%3D
21. Snyder HW, Jr., Mittelman A, Oral A, Messerschmidt GL, Henry DH, Korec S, Bertram JH, Guthrie TH, Jr., Ciavarella D, Wuest D et al (1993) Treatment of cancer chemotherapy-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome by protein A immunoadsorption of plasma. Cancer 71:1882-1892 8448753
22. Verwey J, Boven E, van der Meulen J, Pinedo HM (1984) Recovery from mitomycin C-induced hemolytic uremic syndrome. A case report. Cancer 54:2878-2881 1:STN:280:BiqD2cfmtlU%3D
23. von Baeyer H (2002) Plasmapheresis in thrombotic microangiopathy-associated syndromes: Review of outcome data derived from clinical trials and open studies. Ther Apher 6:320-328 10.1046/j.1526-0968.2002.00390.x