Bronchiolitis obliterans syndrome: Pathogenesis and management

Seminars in Thoracic and Cardiovascular Surgery

Volumn 16, Issue 4, 2004, Pages 350-355

  Hachem, Ramsey R ^a   Trulock, Elbert P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bronchiolitis obliterans syndrome; Lung transplantation; Rejection

Indexed keywords

AZITHROMYCIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIBODY; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ARTICLE; BRONCHIOLITIS OBLITERANS; CHRONIC GRAFT REJECTION; DIAGNOSTIC PROCEDURE; DISEASE SEVERITY; GASTROESOPHAGEAL REFLUX; HUMAN; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; LUNG INSUFFICIENCY; LUNG TRANSPLANTATION; LYMPH NODE IRRADIATION; MORBIDITY; MORTALITY; PATHOGENESIS; PUVA; REOPERATION; RISK FACTOR; TREATMENT OUTCOME;

EID: 11844284855     PISSN: 10430679     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semtcvs.2004.09.011     Document Type: Review

References (88)

1. E.P. Trulock L.B. Edwards D.O. Taylor et al. The Registry of the International Society for Heart and Lung Transplantation: Twentieth Official Adult Lung and Heart-Lung Transplant Report - 2003 J Heart Lung Transplant 22 2003 625-635
2. J.D. Cooper M. Billingham T. Egan et al. A working formulation for the standardization of nomenclature for clinical staging of chronic dysfunction in lung allografts: International Society for Heart and Lung Transplantation J Heart Lung Transplant 12 1993 713-716
3. M. Estenne J.R. Maurer A. Boehler et al. Bronchiolitis obliterans syndrome 2001: An update of the diagnostic criteria J Heart Lung Transplant 21 2002 297-310
4. A. Boehler S. Kesten W. Weder R. Speich Bronchiolitis obliterans after lung transplantation: A review Chest 114 1998 1411-1426
5. R.S. Sundaresan E.P. Trulock T. Mohanakumar et al. Prevalence and outcome of bronchiolitis obliterans syndrome after lung transplantation Ann Thorac Surg 60 1995 1341-1347
6. M. Estenne M.I. Hertz Bronchiolitis obliterans after human lung transplantation Am J Respir Crit Care Med 166 2002 440-444
7. V.G. Valentine R.C. Robbins G.J. Berry et al. Actuarial survival of heart-lung and bilateral sequential lung transplant recipients with obliterative bronchiolitis J Heart Lung Transplant 15 1996 371-383
8. L.C. Paul H. Benediktsson Chronic transplant rejection magnitude of the problem and pathogenetic mechanisms Transplant Rev 7 1993 96-113
9. S.G. Tullius N. Tilney Both alloantigen-dependent and -independent factors influence chronic allograft rejection Transplantation 59 1995 313-318
10. S.A. Yousem G.J. Berry P.T. Cagle et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung rejection study group J Heart Lung Transplant 15 1996 1-15
11. S.A. Yousem Lymphocytic bronchitis/bronchiolitis in lung allograft recipients Am J Surg Path 17 1993 491-496
12. N.P. Ohori A.T. Iacono W.F. Grgurich et al. Significance of acute bronchitis/bronchiolitis in the lung transplant recipient Am J Surg Path 18 12 1994 1192-1204
13. C.A. Keller P.T. Cagle R.W. Brown et al. Obliterative bronchiolitis in recipients of single, double, and heart lung transplantation Chest 107 1995 973-980
14. R.E. Girgis I. Tu G.J. Berry et al. Risk factors for the development of obliterative bronchiolitis after lung transplantation J Heart Lung Transplant 15 1996 1200-1208
15. K. Bando I.L. Paradis S. Similo et al. Obliterative bronchiolitis after lung and heart-lung transplantation: An analysis of risk factors and management J Thorac Cardiovasc Surg 110 1995 4-13
16. D. Heng L.D. Sharples K. McNeil et al. Bronchiolitis obliterans syndrome: Incidence, natural history, prognosis, and risk factors J Heart Lung Transplant 17 1998 1255-1263
17. S. Kesten A. Maidenberg T. Winton et al. Treatment of presumed and proven acute rejection following six months of lung transplant survival Am J Respir Crit Care Med 152 1995 1321-1324
18. L.D. Sharples M. Tamm K. McNeil et al. Development of bronchiolitis obliterans syndrome in recipients of heart-lung transplantation - Early risk factors Transplantation 61 1996 560-566
19. T.J. Kroshus V.R. Kshettry K. Savik et al. Risk factors for the development of bronchiolitis obliterans syndrome after lung transplantation J Thorac Cardiovasc Surg 114 1997 195-202
20. A.N. Husain M.T. Siddiqui E.W. Holmes et al. Analysis of risk factors of the development of bronchiolitis obliterans syndrome Am J Respir Crit Care Med 159 1999 829-833
21. P.M. Hopkins C.L. Aboyoun P.N. Chhajed et al. Outcome of minimal acute rejection (grade A1) in lung transplant recipients: The need for careful observation J Heart Lung Transplant 21 2002 A144
22. D.J. Ross A. Marchevsky M. Kramer et al. Refractoriness of airflow obstruction associated with isolated lymphocytic bronchiolitis/bronchitis in pulmonary allografts J Heart Lung Transplant 16 1997 832-838
23. H. Reichenspurner R.E. Girgis R.C. Robbins et al. Stanford experience with obliterative bronchiolitis after lung and heart-lung transplantation Ann Thorac Surg 62 1996 1467-1472
24. A. El Gamel E. Sim P. Hasleton et al. Transforming growth factor beta (TGF-β) and obliterative bronchiolitis following pulmonary transplantation J Heart Lung Transplant 18 1999 828-837
25. N.A. Ettinger T.C. Bailey E.P. Trulock et al. Cytomegalovirus infection and pneumonitis. Impact after isolated lung transplantation. Washington University Lung Transplant Group Am Rev Respir Dis 147 1993 1017-1023
26. R.J. Keenan M.E. Lega J.S. Dummer et al. Cytomegalovirus serologic status and postoperative infection correlated with risk of developing chronic rejection after pulmonary transplantation Transplantation 51 1991 433-438
27. L.L. Schulman A.D. Weinberg C.C. McGregor et al. Influence of donor and recipient HLA locus mismatching on development of obliterative bronchiolitis after lung transplantation Am J Respir Crit Care Med 163 2001 437-442
28. J.W.K. van den Berg B.G. Hepkema A. Geertsma et al. Long-term outcome of lung transplantation is predicted by the number of HLA-DR mismatches Transplantation 71 2001 368-373
29. W. Chalermskulrat I.P. Neuringer J.L. Schmitz et al. Human leukocyte antigen mismatches predispose to the severity of bronchiolitis obliterans syndrome after lung transplantation Chest 123 2003 1825-1831
30. M.A. Quantz L.E. Bennett D.M. Meyer et al. Does human leukocyte antigen matching influence the outcome of lung transplantation? An analysis of 3,549 lung transplantations J Heart Lung Transplant 19 2000 473-479
31. A. Jaramillo M.A. Smith D. Phelan et al. Development of ELISA-detected anti-HLA antibodies precedes the development of bronchiolitis obliterans syndrome and correlates with progressive decline in pulmonary function after lung transplantation Transplantation 67 1999 1155-1161
32. S.I. Reznik A. Jaramillo L. Zhang et al. Anti-HLA antibody binding to HLA class I molecules induces proliferation of airway epithelial cells: A potential mechanism for bronchiolitis obliterans syndrome J Thorac Cardiovasc Surg 119 2000 39-45
33. A. Jaramillo C.R. Smith T. Maruyama et al. Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: A possible mechanism for bronchiolitis obliterans syndrome Human Immunol 64 2003 521-529
34. L. Compte V. Garrigues M. Perpina et al. Prevalence of gastroesophageal reflux in asthma J Asthma 37 2000 175-182
35. A. Liou J.R. Grubb K.B. Schechtman et al. Causative and contributive factors to asthma severity and patterns of medication use in patients seeking specialized asthma care Chest 124 2003 1781-1788
36. R.W. Tobin C.E. Pope C.A. Pellegrini et al. Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis Am J Respir Crit Care Med 158 1998 1804-1808
37. K.R. Reid F.N. McKenzie A.H. Menkis et al. Importance of chronic aspiration in recipients of heart-lung transplants Lancet 336 1990 206-208
38. M. Rinaldi L. Martinelli G. Volpato et al. Gastro-esophageal reflux as cause of obliterative bronchiolitis: A case report Transplant Proc 27 1995 2006-2007
39. S.M. Palmer A.P. Miralles D.N. Howell et al. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation Chest 118 2000 1214-1217
40. R.D. Davis C.L. Lau S. Eubanks et al. Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation J Thorac Cardiovasc Surg 125 2003 533-542
41. F. D'Ovidio M. Mura T.K. Waddell et al. Bile acids in bronchoalveolar lavage after lung transplantation as a marker of pulmonary aspiration associated with alveolar neutrophilia J Heart Lung Transplant 23 2004 S3
42. M.G. Hartwig E. Cantu J.Z. Appel et al. Non-alloimmune injury mediated by gastroesophageal reflux precipitates alloimmune injury in lung transplant recipients J Heart Lung Transplant 23 2004 S4
43. J.D. Christie J.E. Bavaria H.I. Palevsky et al. Primary graft failure following lung transplantation Chest 114 1998 51-60
44. S.U. Khan J. Salloum P.B. O'Donovan et al. Acute pulmonary edema after lung transplantation. The pulmonary reimplantation response Chest 116 1999 187-194
45. R.C. King O.A.R. Binns F. Rodriguez et al. Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation Ann Thorac Surg 69 2000 1681-1685
46. W.M. Chatila S. Furukawa J.P. Gaughan et al. Respiratory failure after lung transplantation Chest 123 2003 165-173
47. M. de Perrot M. Liu T.K. Waddell et al. Ischemia-reperfusion-induced lung injury Am J Respir Crit Care Med 167 2003 490-511
48. S.M. Fiser C.G. Tribble S.M. Long et al. Ischemia-reperfusion injury after lung transplantation increases the risk of late bronchiolitis obliterans syndrome Ann Thorac Surg 73 2002 1041-1048
49. J.D. Hosenpud L.E. Bennett B.M. Keck et al. The Registry of the International Society for Heart and Lung Transplantation: Eighteenth Official Report - 2001 J Heart Lung Transplant 20 2001 805-815
50. H.D. Tazelaar S.A. Yousem The pathology of combined heart-lung transplantation: An autopsy study Hum Pathol 19 1988 1403-1416
51. M.R. Kramer C. Stoehr J.L. Whang et al. The diagnosis of obliterative bronchiolitis after heart-lung and lung transplantation: Low yield of transbronchial lung biopsy J Heart Lung Transplant 12 1993 675-681
52. G.M. Patterson S. Wilson J.L. Whang et al. Physiologic definitions of obliterative bronchiolitis in heart-lung and double lung transplantation: A comparison of the forced expiratory flow between 25% and 75% of the forced vital capacity and forced expiratory volume in one second J Heart Lung Transplant 15 1996 175-181
53. M. Estenne A. Van Muylem C. Knoop et al. Detection of obliterative bronchiolitis after lung transplantation by indexes of ventilation distribution Am J Respir Crit Care Med 162 2000 1047-1051
54. M. Reynaud-Gaubert P. Thomas M. Badier et al. Early detection of airway involvement in obliterative bronchiolitis after lung transplantation: functional and bronchoalveolar cell findings Am J Respir Crit Care Med 161 2000 1924-1929
55. S.D. Nathan S.D. Barnett J. Wohlrab et al. Bronchiolitis obliterans syndrome: Utility of the new guidelines in single lung transplant recipients J Heart Lung Transplant 22 2003 427-432
56. R.R. Hachem M.C. Chakinala R.D. Yusen et al. The predictive value of bronchiolitis obliterans syndrome stage 0-p Am J Respir Crit Care Med 169 2004 468-472
57. American Thoracic Society Lung function testing: Selection of reference values and interpretative strategies Am Rev Respir Dis 144 1991 1202-1218
58. B.E. Pennock R.M. Rogers D.R. McCaffree Changes in measured spirometric indices: What is significant? Chest 80 1981 97-99
59. J.A.B. Martinez I.L. Paradis J.H. Dauber et al. Spirometry values in stable lung transplant recipients Am J Respir Crit Care Med 155 1997 285-290
60. J.C. Hogg P.T. Macklem W.M. Thurlbeck et al. Site and nature of airway obstruction in chronic obstructive lung disease N Engl J Med 278 1968 1355-1360
61. A.N. Leung K. Fisher V. Valentine et al. Bronchiolitis obliterans after lung transplantation - Detection using expiratory HRCT Chest 113 1998 365-370
62. E.S. Lee M.B. Gotway G.P. Reddy et al. Early bronchiolitis obliterans following lung transplantation: Accuracy of expiratory thin-section CT for diagnosis Radiology 216 2000 472-477
63. A.A. Bankier A. Van Muylen C. Knoop et al. Bronchiolitis obliterans syndrome in heart-lung transplant recipients: Diagnosis with expiratory CT Radiology 218 2001 533-539
64. 3He-MRI in follow-up of lung transplant recipients Eur Radiol 14 2004 78-85
65. 3He: Comparison with CT J Magn Reson Imaging 15 2002 268-274
66. S.A. Yousem I. Paradis B.P. Griffith et al. Can transbronchial biopsy aid in the diagnosis of bronchiolitis obliterans in lung transplant recipients? Transplantation 57 1994 151-153
67. D. Chamberlain J. Maurer C. Chaparro et al. Evaluation of transbronchial lung biopsy specimens in the diagnosis of bronchiolitis obliterans after lung transplantation J Heart Lung Transplant 13 1994 963-971
68. H. Date J.P. Lynch S. Sundaresan et al. The impact of cytolytic therapy on bronchiolitis obliterans syndrome J Heart Lung Transplant 17 1998 869-875
69. J.W.K. van den Berg A. Geertsma W. van der Bij et al. Bronchiolitis obliterans syndrome after lung transplantation and health-related quality of life Am J Respir Crit Care Med 161 2000 1937-1941
70. J.W.K. van den Berg P.J. van Enckevort E.M. TenVergert et al. Bronchiolitis obliterans syndrome and additional costs of lung transplantation Chest 118 2000 1648-1652
71. B.P. Griffith R.L. Hardesty J.M. Armitage et al. Acute rejection of lung allografts with various immunosuppressive protocols Ann Thorac Surg 54 1992 846-851
72. S.M. Palmer A.P. Miralles C.M. Lawrence et al. Rabbit antithymocyte globulin decreases acute rejection after lung transplantation: Results of a randomized prospective study Chest 116 1999 127-133
73. E.R. Garrity J. Villanueva S.M. Bhorade et al. Low rate of acute lung allograft rejection after the use of daclizumab, an interleukin 2 receptor antibody Transplantation 71 2001 773-777
74. A. Zuckermann H. Reichenspurner T. Birsan et al. Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: One-year results of a 2-center prospective randomized trial J Thorac Cardiovasc Surg 125 2003 891-900
75. S.M. Palmer M.A. Baz L. Sanders et al. Results of a randomized, prospective, multicenter trial of mycophenolate mofetil versus azathioprine in the prevention of acute lung allograft rejection Transplantation 71 2001 1772-1776
76. G.I. Snell D.S. Esmore T.J. Williams Cytolytic therapy for the bronchiolitis obliterans syndrome complicating lung transplantation Chest 109 1996 874-878
77. S. Kesten N. Rajagopalan J. Maurer Cytolytic therapy for the treatment of bronchiolitis obliterans syndrome following lung transplantation Transplantation 61 1996 427-430
78. A.T. Iacono R.J. Keenan S.R. Duncan et al. Aerosolized cyclosporine in lung recipients with refractory chronic rejection Am J Respir Crit Care Med 153 1996 1451-1455
79. A.T. Iacono T.E. Corcoran B.P. Griffith et al. Aerosol cyclosporine therapy in lung transplant recipients with bronchiolitis obliterans Eur Respir J 23 2004 384-390
80. K. Sarahrudi M. Estenne P. Corris et al. International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection J Thorac Cardiovasc Surg 127 2004 1126-1132
81. M. Dusmet J. Maurer T. Winton et al. Methotrexate can halt the progression of bronchiolitis obliterans syndrome in lung transplant recipients J Heart Lung Transplant 15 1996 948-954
82. G.M. Verleden B. Buyse M. Delcroix et al. Cyclophosphamide rescue therapy for chronic rejection after lung transplantation J Heart Lung Transplant 18 1999 1139-1142
83. B.C. Cahill K.T. Somerville J.A. Crompton et al. Early experience with sirolimus in lung transplant recipients with chronic allograft rejection J Heart Lung Transplant 22 2003 169-176
84. S.G. Gerhardt J.F. McDyer R.E. Girgis et al. Maintenance azithromycin therapy for bronchiolitis obliterans syndrome. Results of a pilot study A\m J Respir Crit Care Med 168 2003 121-125
85. D.A. Diamond J.M. Michalski J.P. Lynch et al. Efficacy of total lymphoid irradiation for chronic allograft rejection following bilateral lung transplantation Int J Radiation Oncology Biol Phys 41 1998 795-800
86. A.R. O'Hagan P.C. Stillwell A. Arroliga et al. Photopheresis in the treatment of refractory bronchiolitis obliterans complicating lung transplantation Chest 115 1999 1459-1462
87. S.M. Levine A survey of clinical practice of lung transplantation in North America Chest 125 2004 1224-1238
88. R.J. Novick L.W. Stitt K. Al-Kattan et al. Pulmonary retransplantation: Predictors of graft function and survival in 230 patients Ann Thorac Surg 65 1998 227-234