Capgras syndrome: A review of the neurophysiological correlates and presenting clinical features in cases involving physical violence

Canadian Journal of Psychiatry

Volumn 49, Issue 11, 2004, Pages 719-725

  Bourget, Dominique ^a,b,c   Whitehurst, Laurie ^c  

^a UNIVERSITY OF OTTAWA   (Canada)

^b ROYAL OTTAWA HOSPITAL   (Canada)

^c Department of Psychology ^*  (Canada)

Author keywords

Capgras syndrome; Delusional misidentification; Violence

Indexed keywords

ANTIDEPRESSANT AGENT; MIRTAZAPINE; NEUROLEPTIC AGENT; OLANZAPINE; PIMOZIDE; RISPERIDONE; SULPIRIDE; TRIFLUOPERAZINE;

CAPGRAS SYNDROME; CASE STUDY; CLINICAL FEATURE; CORRELATION ANALYSIS; DELUSION; DEMOGRAPHY; DISEASE ACTIVITY; DISEASE COURSE; HUMAN; NEUROPHYSIOLOGY; NEUROPSYCHIATRY; REVIEW; RISK FACTOR; VIOLENCE;

EID: 11844283359     PISSN: 07067437     EISSN: None     Source Type: Journal    
DOI: 10.1177/070674370404901102     Document Type: Review

References (141)

1. Capgras J, Reboul-Lachaux J. Illusions des sosies dans un délire systématisé chronique. Bull Soc Clin Méd Ment 1923;11:6-16.
2. Todd J, Dewhurst K, Wallis G. The syndrome of Capgras. Br J Psychiatry 1981;139:319-27.
3. Christodoulou GN. The syndrome of Capgras. Br J Psychiatry 1977;130:556-64.
4. Alexander MP, Stuss DT, Benson DF. Capgras syndrome: a reduplicative phenomenon. Neurology 1979;334-9.
5. Frazer SJ, Roberts JM. Three cases of Capgras' syndrome. Br J Psychiatry 1994;164:557-9.
6. Mendez MF. Delusional misidentification of persons in dementia. Br J Psychiatry 1992;160:414-6.
7. Ellis HD, de Pauw KW, Christodoulou GN, Papageorgiou L, Milne AB, Joseph AB. Responses to facial and nonfacial stimuli presented tachistoscopically in either or both visual fields by patients with the Capgras delusion and paranoid schizophrenics. J Neurol Neurosurg Psychiatry 1993;56:215-9.
8. Silva JA, Leong GB, Lesser IM, Boone KB. Bilateral cerebral pathology and the genesis of delusional misidentification. Can J Psychiatry 1995;40:498-9.
9. Oyebode F, Sargeant R. Delusional misidentification syndromes: a descriptive study. Psychopathology 1996;29:209-14.
10. Cenec-Thaly H, Frelot C, Guinard M, Tricot JC, Lacour MA. L'illusion des sosies. Ann Médico-psychol 1962;120:481-94.
11. Mak KY, Wong CW, Lo WH. The Capgras syndrome in the Chinese. Journal of the Hong Kong Psychiatric Association 1985;5:14-7.
12. Chawla HM, Buchan T, Galen N. Capgras syndrome: a case report from Zimbabwe. Br J Psychiatry 1987;151:254-6.
13. de Pauw KW, Szulecka TK. Dangerous delusions. Violence and the misidentification syndromes. Br J Psychiatry 1988;152:91-6.
14. Forstl H, Almeida OP, Owen AM, Burns A, Howard R. Psychiatric, neurological and medical aspects of misidentification syndromes: a review of 260 cases. Psychol Med 1991;21:905-10.
15. Tenyi T, Trixler M. The Capgras-symptom in schizophrenic psychoses. Psychiatria Hungarica 1991;6:243-7.
16. Burjorjee RN, Al-Adawi S. Delusional misidentification of Capgras: a case report from Oman. J Nerv Ment Dis 1992;180:733-4.
17. Sverd J. Comorbid Capgras syndrome. J Am Acad Child Adolesc Psychiatry 1995;34:538-9.
18. Kourany RF. Capgras syndrome variant in an 8 1/2 year old boy. J Am Acad Child Psychiatry 1983;22:571-2.
19. Burns A. The oldest patient with Capgras syndrome. Br J Psychiatry 1985;147:719-20.
20. Kumar V. Capgras Syndrome in a patient with dementia. Br J Psychiatry 1987;150:251.
21. Hart J, McClure GM. Capgras syndrome and folie a deux involving mother and child. Br J Psychiatry 1989;154:552-4.
22. Burns A, Jacoby R, Levy R. Psychiatric phenomena in Alzheimer's disease. II: Disorders of perception. Br J Psychiatry 1990;157:76-81.
23. Jackson RS, Naylor MW, Shain B, King CA. Capgras syndrome in adolescence. J Am Acad Child Adolesc Psychiatry 1992;31:5.
24. Tueth MJ, Cheong JA. Successful treatment with pimozide of Capgras syndrome in an elderly male. J Geriatr Psychiatry Neurol 1992;5:217-9.
25. Sims A, White J. Coexistence of Capgras and de Clérambault syndromes. A case history. Br J Psychiatry 1973;123:635-7.
26. Vogel RF. The Capgras syndrome and its psychopathology. Am J Psychiatry 1974;131:922-4.
27. Anderson DN, Williams E. The delusion of inanimate doubles. Psychopathology 1994;27:220-5.
28. Cutting J. The phenomenology of acute organic psychosis: comparison with acute schizophrenia. Br J Psychiatry 1987;151:324-32.
29. Cutting J. Evidence for right hemisphere dysfunction in schizophrenia. In: David AS, Cutting JC, editors. The neuropsychology of schizophrenia. Oxford (UK): Oxford University Press; 1994.
30. Kirov G, Jones P, Lewis SW. Prevalence of delusional misidentification syndromes. Psychopathology 1994;27:148-9.
31. Christodoulou GN. The delusional misidentification syndromes. Br J Psychiatry 1991;159:65-9.
32. Berson RJ. Capgras syndrome. Am J Psychiatry 1983;140:969-78.
33. Kimura S. Review of 106 cases with the syndrome of Capgras. Biblio Psychiatr 1986;164:121-30.
34. Walter-Ryan WG. Capgras' syndrome and misidentification. Am J Psychiatry 1986;143:126.
35. Haslam MT. A case of Capgras syndrome. Am J Psychiatry 1973;130:493-4.
36. Forstl H, Burns A, Jacoby R, Levy R. Neuroanatomical correlates of clinical misidentification and misperception in senile dementia of the Alzheimer type. J Clin Psychiatry 1991;52:268-71.
37. Odom-White A, de Leon J, Stanilla J, Cloud BS, Simpson GM. Misidentification syndromes in schizophrenia: case reviews with implications for classification and prevalence. Aust N Z J Psychiatry 1995;29:63-8.
38. Nilsson R, Perris C. The Capgras syndrome: a case report. Acta Psychiatr Scand (Suppl) 1971;221:53-8.
39. Merriam AE, Aronson MK, Gaston P, Wey SL, Katz I. The psychiatric symptoms of Alzheimer's disease. J Am Geriatr Soc 1988;36:7-12.
40. Ballard CG, Saad, K, Patel A, Gahir M, Solis M, Coope B, and others. The prevalence and phenomenology of psychotic symptoms in dementia sufferers. Int J Geriatr Psychiatry 1995;10:477-85.
41. Drake J. Post-ictal Capgras syndrome. Clin Neurol Neurosurg 1987;89:271-4.
42. Lewis SW. Brain imaging in a case of Capgras syndrome. Br J Psychiatry 1987;150:117-21.
43. Sumners D. Believing your husband has been replaced by an impostor because you have a pituitary tumour. BMJ 1984;289:699-700.
44. Anderson DN. The delusion of inanimate doubles: implications for understanding the Capgras phenomenon. Br J Psychiatry 1988;153:694-9.
45. Collins MN, Hawthorne ME, Gribben N, Jacobson R. Capgras syndrome with organic disorders. Postgrad Med J 1990;66:1064-7.
46. Bouckoms A, Martuza R, Henderson M. Capgras syndrome with subarachnoid haemorrhage. J Nerv Ment Dis 1986;174:484-8.
47. Marantz AG, Verghese J. Capgras' syndrome in dementia with Lewy bodies. J Geriatr Psychiatr Neurol 2002;15:239-41.
48. Edelstyn NM, Oyebode F. A review of the phenomenology and cognitive neuropsychological origins of the Capgras syndrome. Int J Geriatr Psychiatry 1999;14:48-59.
49. Roane DM, Rogers JK, Robinson JH, Feinberg TE. Delusional misidentification in association with parkinsonism. J Neuropsychiatry Clin Neurosci 1998;10:194-8.
50. Hermanowicz N. A blind man with Parkinson's disease, visual hallucinations, and Capgras syndrome. J Neuropsychiatry Clin Neurosci 2002;14:462-3.
51. Crichton R, Lewis S. Delusional misidentification, AIDS and the right hemisphere. Br J Psychiatry 1990;157:608-10.
52. MacCallum WAG. Capgras symptoms with an organic basis. Br J Psychiatry 1973;123:639-42.
53. Quinn D. The Capgras syndrome: two case reports and a review. Can J Psychiatry 1981;26:126-9.
54. Canagasabey B, Katona CLE. Capgras syndrome in association with lithium toxicity. Br J Psychiatry 1991;159:879-81.
55. McPhillips MA, Moscovich DG. Capgras' syndrome in association with lithium toxicity. Br J Psychiatry 1992;160:573-4.
56. Bhatia MS. Capgras syndrome in a patient with migraine. Br J Psychiatry 1990;157:917-8.
57. Capgras J, Carrette P. Illusions des sosies et complex d'oedipe. Ann Médico-psychol 1924;82:48-68.
58. Davidson GH. The syndrome of Capgras. Psychiatr Q 1941;15:513-21.
59. Murray JR. A case of Capgras syndrome in the male. J Ment Sci 1936;82:63-6.
60. Dally P, Gomez J. Capgras: case study and reappraisal. Br J Med Psychol 1979;52:291-5.
61. Munro A. Delusional disorder. Paranoia and related illnesses. Cambridge (UK): Cambridge University Press; 1999.
62. Daniel DG, Swallows A, Wolff F. Capgras delusion and seizures in association with therapeutic dosage disulfiram. South Med J 1987;80:1577-9.
63. McAllister TW. Neuropsychiatric aspects of delusions. Psychiatr Ann 1992;22:269-77.
64. Potts SG. Lithium intoxication presenting as a mixed misidentification syndrome. Behav Neurol 1992;5:19-22.
65. Lehmann HE. Unusual psychiatric disorders, atypical psychosis and brief reactive psychoses. In: Kaplan HI, Freedman AM, Sadock BJ, editors. Comprehensive textbook of psychiatry. 6th ed. Baltimore (MD): Lippincott, Williams & Williams; 1988.
66. Alevizos B, Christodoulou GN. MAO activity in patients with delusional misidentification. In: Pichot P, Beenez P, Wolf R, Thau K, editors. Psychiatry: the state of the art. New York: Plenum; 1985.
67. Cutting J. Delusional misidentification and the role of right hemisphere in the appreciation of identity. Br J Psychiatry 1991;159:70-5.
68. Silva AJ, Leong GB, Wine DB. Misidentification delusions, facial misrecognition and right brain injury. Can J Psychiatry 1993;38:239-41.
69. Forstl H, Besthorn C, Burns A, Geiger-Kabisch C, Levy R, Sattel A. Delusional misidentification in Alzheimer's disease: a summary of clinical and biological aspects. Psychopathology 1994;27:194-9.
70. Joseph AB. Focal nervous system abnormalities in patients with misidentification syndromes. Biblio Psychiatr 1986;164:68-79.
71. Signer SF. Localisation and lateralization in the delusion of substitution. Psychopathology 1994;27:168-76.
72. Diesfeldt HF, Troost D. Delusional misidentification and subsequent dementia: a clinical and neuropathological study. Dementia 1995;6:94-8.
73. Joseph AB, O'Leary DH, Wheeler HG. Bilateral atrophy of the frontal and temporal lobes in schizophrenic patients with Capgras syndrome: a case control study using computed tomography. J Clin Psychiatry 1990;51:322-5.
74. Forstl H, Almeida OP, Iacoponi E. Capgras delusion in the elderly: the evidence for a possible organic origin. Int J Geriatr Psychiatry 1991;6:845-52.
75. Mentis MJ, Weinstein EA, Horwitz B, McIntosh AR, Pietrini P, Alexander GE, and others. Abnormal brain glucose metabolism in the delusional misidentification syndromes: a positron emission tomography study in Alzheimer disease. Biol Psychiatry 1995;38:438-49.
76. Morrison RL, Tartar RE. Neuropsychological findings relating to Capgras syndrome. Biol Psychiatry 1984;19:1119-27.
77. Harwood DG, Barker WW, Ownby FL, Duara R. Prevalence and correlates of Capgras syndrome in Alzheimer's disease. Int J Geriatr Psychiatry 1999;14:415-20.
78. Edelstyn NM, Oyebode F, Barrett K. The delusions of Capgras and intermetamorphosis in a patient with right-hemisphere white-matter pathology. Psychopathology 2001;34:299-304.
79. Lykouras L, Typaldou M, Gournellis R, Vaslamatzis G, Christodoulou GN. Coexistence of Capgras and Frégoli syndromes in a single patient. Clinical, neuroimaging and neuropsychological findings. Eur Psychiatry 2002;17:234-5.
80. Staton RD, Brumback RA, Wilson H. Reduplicative paramnesia: a disconnection syndrome of memory. Cortex 1982;18:23-36.
81. Hayman MA, Abrams R. Capgras syndrome and cerebral dysfunction Br J Psychiatry 1977;130:68-71.
82. Meadows JC. The anatomical basis of prosopagnosia. J Neurol Neurosurg Psychiatry 1974;37:489-501.
83. Shraberg D, Weitzel WD. Prosopagnosia and the Capgras syndrome. J Clin Psychiatry 1979;40:313-6.
84. Damasio AR, Damasio H, Van Howsen GW. Prosopagnosia: anatomical basis and behavioural mechanisms. Neurology 1982;32:331-41.
85. De Renzi E, Perani D, Carlesimo GA, Silveri MC, Fazio F. Prosopagnosia can be associated with damage confined to the right hemisphere an MRI and PET study and a review of the literature. Neuropsychologia 1994;32:893-902.
86. Ellis HD, Young AW. Accounting for delusional misidentification. Br J Psychiatry 1990;157:239-48.
87. Ellis A, Young AW, Quayle AH, de Pauw KW. Reduced anatomic responses to faces in Capgras delusion. Proc R Soc Lond B Biol Sci 1997;264:1085-92.
88. Hirstein W, Ramachandran VS. Capgras syndrome: a novel probe for understanding the neural representation of the identity and familiarity of persons. Proc R Soc Lond B Biol Sci 1997;264:437-44.
89. Paillère-Martinot ML, Dao-Castellana MH, Masure MC, Pillon B, Martinot JL. Delusional misidentification: a clinical, neuropsychological and brain imaging case study. Psychopathology 1994;27:200-10.
90. Turner RS, Chervin RD, Frey KA, Minoshima S, Kuhl DE. Probable diffuse Lewy body disease presenting as REM sleep behavior disorder. Neurology 1997;49:523-7.
91. Turner RS, D'Amato CJ, Chervin RD, Blaivas M. The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. Neurology 2000;55:1730-2.
92. Rojo VI, Caballero L, Irucla LM, Baca E. Capgras syndrome in a blind patient. Am J Psychiatry 1991;148:1272.
93. Reid I, Young AW, Hellawell DJ. Voice recognition impairment in a blind Capgras patient. Behav Neurol 1993;6:225-8.
94. Swanson J, Holzer C, Ganju V, Jono R. Violence and psychiatric disorder in the community: evidence from the Epidemiological Catchment Area surveys. Hosp Community Psychiatry 1990;41:761-70.
95. Shah AK, Fineberg NA, James DV. Violence among psychiatric inpatients. Acta Psychiatr Scand 1991;84:305.
96. Swanson JW, Holzer CE. Violence and ECA data. Hosp Community Psychiatry 1991;42:944-55.
97. Hodgins S. Mental disorder, intellectual deficiency, and crime. Arch Gen Psychiatry 1992;49:476-83.
98. Monahan J. Mental disorder and violent behavior: perceptions and evidence. Am Psychologist 1992;47:511-21.
99. Link B, Cullen F, Andrews H. Violent and illegal behavior of current and former mental patients compared to community controls. Am Sociol Rev 1992;57:275-92.
100. Swanson JW. Alcohol abuse, mental disorder, and violent behavior. An epidemiologic inquiry. Alcohol Health Res World 1993;17:123-32.
101. Wessely SC, Castle D, Douglas AJ, Taylor PJ. The criminal careers of incident cases of schizophrenia. Psychol Med 1994;24:483-502.
102. Eronen M, Tiihonen J, Hakola P. Schizophrenia and homicidal behavior. Schizophr Bull 1996;22:83-9.
103. Eronen M, Hakola P, Tiihonen J. Mental disorders and homicidal behavior in Finland. Arch Gen Psychiatry 1996;53:497-501.
104. Shaw J, Appleby L, Amos T, McDonnell R, Harris C, McCann K, and others. Mental disorder and clinical care in people in people convicted of homicide: national clinical survey. BMJ 1999;318:1240-4.
105. Benezech M, Bourgeois M, Yesavage J. Violence in the mentally ill: a study of 547 patients at a French hospital for the criminally insane. J Nerv Ment Dis 1980;168:698-700.
106. Nestor PG, Haycock J, Doiron S, Kelly J, Kelly D. Lethal violence and psychosis: a clinical profile. Bull Am Acad Psychiatry Law 1995;23:331-41.
107. Crane DL. More violent Capgras. Am J Psychiatry 1976;133:1350.
108. Christodoulou GN. Syndrome of subjective doubles. Am J Psychiatry 1978;135:249-51.
109. Blount G. Dangerousness of patients with Capgras syndrome. Nebr Med J 1986;71:207.
110. O'Reilly R, Malhotra L. Capgras syndrome an unusual case and discussion of psychodynamic factors. Br J Psychiatry 1987;151:263-5.
111. Silva JA, Leong GB, Weinstock R, Boyer CL. Capgras syndrome and dangerousness. Bull Am Acad Psychiatry Law 1989;17:5-14.
112. Driscoll R, Chithiramohan R, Brockman B. Capgras syndrome, mania, and delusionally motivated assaults. J Forensic Psychiatry 1991;2:51-7.
113. Silva JA, Sharma KK, Leong GB, Weinstock R. Dangerousness of the delusional misidentification of children. J Forensic Sci 1992;37:830-8.
114. Silva JA, Leong GB, Weinstock R. The dangerousness of persons with misidentification syndromes. Bull Am Acad Psychiatry Law 1992;20:77-86.
115. Thompson AE, Swan M. Capgras syndrome presenting with violence following heavy drinking. Br J Psychiatry 1993;162:692-4.
116. Silva JA, Leong GB, Garza-Treviño ES, Le Grand J, Oliva D, Weinstock R, and others. A cognitive model of dangerous delusional misidentification syndromes. J Forensic Sci 1994;39:1455-67.
117. Silva JA, Leong GB, Weinstock R, Penny G. Dangerous delusions of misidentification of the self. J Forensic Sci 1995;40:570-3.
118. Kimura S, Inamoto Y, Katsurada T. A rare case of Capgras syndrome observed in wakeamine induced psychosis. Folia Psychiatrica et Neurologica Japonica 1981;35:43-54.
119. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington (DC): APA; 1994.
120. Enoch MD, Trethowan W. Uncommon psychiatric syndromes. Oxford (UK): Butterworth-Heinemann; 1979.
121. Nestor PG. Neuropsychological and clinical correlates of murder and other forms of extreme violence in a forensic psychiatric hospital. J Nerv Ment Dis 1992;180:418-23.
122. Weinstock R. Capgras syndrome: a case involving violence. Am J Psychiatry 1976;133:855.
123. Romanik RL, Snow S. Two cases of Capgras' syndrome. Am J Psychiatry 1984;141:720.
124. Woytassek LE, Atwal SS. Capgras syndrome in court. Nebr Med J 1985;70:392-4.
125. Fishbain DA. The frequency of Capgras delusions in a psychiatric emergency service. Psychopathology 1987;20:42-7.
126. Miller BL, Lesser IM, Boone K, Goldberg M, Hill E, Miller MH, and others. Brain white matter lesions and psychosis. Br J Psychiatry 1989;155:73-8.
127. Driscoll R, Chithiramohan R, Brockman B. Capgras syndrome, mania and delusionally motivated assaults. Journal of Forensic Psychiatry 1991;2:51-7.
128. Silva JA, Leong GB, Weinstock R, Ferrari MM. Misidentified political figures: an underappreciated danger. J Forensic Sci 1991;36:1170-8.
129. Casu G, Cascella N, Maggini C. Homicide in Capgras' syndrome. Psychopathology 1994;27:281-4.
130. Kennedy HG, Kemp LI, Dyer DE. Fear and danger in delusional (paranoid) disorder: the association with violence. Br J Psychiatry 1992;160:488-92.
131. Koritar E, Steiner W. Capgras' syndrome: a synthesis of various viewpoints. Can J Psychiatry 1988;33:62-6.
132. Helzer JE, Pryzbeck TR. The co-occurrence of alcoholism with other psychiatric disorders in the general population and its impact on treatment. J Stud Alcohol 1988;49:219-24.
133. Drake RE, Osher FC, Noordsy DL, Gurlbut SC, Teague GB, Beaudett MS. Diagnosis of alcohol use disorders in schizophrenia. Schizophr Bull 1990;16:57-67.
134. Siomopoulos V, Goldsmith J. Two reports of the Capgras syndrome. Am J Psychiatry 1975;132:756.
135. Silva JA, Leong GB. A case of inanimate doubles syndrome. Can J Psychiatry 1995;40:277.
136. Passer KM, Warnock JK. Pimozide in the treatment of Capgras' syndrome. Psychosomatics 1991;32:446-8.
137. Khouzam HR. Capgras syndrome responding to the antidepressant mirtazapine. Comprehensive Therapy 2002;28:238-40.
138. Steinert TS, Wiebe C, Gebhardt, RP. Aggressive behavior against self and others among first-admission patients with schizophrenia. Psychiatr Serv 1999;50:85-90.
139. Richardson MA, Craig TJ, Haughland G. Treatment patterns of young chronic schizophrenic patients in the era of deinstitutionalization. Psychiatr Q 1985;57:243-9.
140. Lindqvist P, Allebeck P. Schizophrenia and assaultive behaviour: the role of alcohol and drug abuse. Acta Psychiatr Scand 1989;82:191-5.
141. Schwartz RC, Reynolds CA, Austin JF, Petersen S. Homicidality in schizophrenia: a replication study. Am J Orthopsychiatry 2003;73:74-7.