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11844249230
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note
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Reactions using silica gels of various pore and mesh sizes revealed that reducing the mesh size reduced the product yield, whereas changing the pore size had comparatively little effect.
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0036012053
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R. Hiroi, N. Miyoshi, and M. Wada, Chem. Lett., 2002, 274.
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Chem. Lett.
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Hiroi, R.1
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20
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11844292687
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note
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In a reaction performed at -5°C, deliberate addition of water (1 mmol) to the prepared support, before adding the organic reagents, afforded only 40% of 4a. When no water was added, but the pre-formed imine, N-benzylidineaniline was used, coupling with 3a gave 4a in 84% yield.
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11844285580
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Tokyo, March, Abstr., No. 2G9-09
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Presented at the 81st Annual Meeting of the Chemical Society of Japan, Tokyo, March 2002, Abstr., No. 2G9-09. Silica gel is an established dehydrating reagent but its effect, in the present study, is unknown.
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81st Annual Meeting of the Chemical Society of Japan
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22
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11844269136
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note
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3), filtered through a plug of cotton wool and, after evaporation of solvent, the organic residue was purified by TLC (n-hexane:ethyl acetate = 7:1 as an eluenl) to give 2,2-dimethyl-3-phenylamino-3-p-tolylpropionic acid methyl ester (255 mg, 90%) as a yellow solid.
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