Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19

Biochemical Pharmacology

Volumn 69, Issue 3, 2005, Pages 525-529

  Hamdan Khalil, Rima ^a   Gala, Jean Luc ^b   Allorge, Delphine ^a   Lo Guidice, Jean Marc ^a   Horsmans, Yves ^c   Houdret, Nicole ^a   Broly, Franck ^a  

^a France Institut Pasteur de Lille   (France)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

6 Thioguanine; Azathioprine; Deficient methylator; Genetic polymorphism; Heterologous expression; TPMT

Indexed keywords

ARGININE; HISTIDINE; MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE; THIOPURINE METHYLTRANSFERASE 16; THIOPURINE METHYLTRANSFERASE 19; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; COLON CROHN DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME MECHANISM; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC CORRELATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROLOGOUS EXPRESSION; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN METHYLATION; WILD TYPE;

ALLELES; GENOTYPE; HUMANS; METHYLTRANSFERASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11844274653     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.10.011     Document Type: Article

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