Pharmacodynamics and pharmacokinetics of high-dose oxycodone infusion during and after coronary artery bypass grafting

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 18, Issue 6, 2004, Pages 748-754

  Pöyhiä, Reino ^a,b   Hynynen, Markku ^d   Seppälä, Timo ^c   Roine, Risto O ^b   Verkkala, Kalervo ^b   Olkkola, Klaus T ^e  

^a Dept Anaesthesia Intensive Care H ^*  (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d JORVI HOSPITAL   (Finland)

^e TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

cardiac surgery; cardiopulmonary bypass; cortisol; enflurane; high dose opioid anesthesia; histamine; oxycodone; pharmacodynamics; pharmacokinetics

Indexed keywords

DRUG METABOLITE; ENFLURANE; EPHEDRINE; HISTAMINE; HYDROCORTISONE; LORAZEPAM; NOROXYCODONE; OXYCODONE; PANCURONIUM; THIOPENTAL; UNCLASSIFIED DRUG;

ADULT; AGED; ANESTHESIA INDUCTION; ANESTHETIC RECOVERY; ARTICLE; AWARENESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DRUG INFUSION; DRUG MEGADOSE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; HEMODYNAMIC MONITORING; HISTAMINE RELEASE; HUMAN; INTUBATION; MALE; PERIOPERATIVE PERIOD; POSTOPERATIVE ANALGESIA; POSTOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECALL;

ANALGESICS, OPIOID; ANESTHETICS, COMBINED; ANESTHETICS, INHALATION; CORONARY ARTERY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; ENFLURANE; FEMALE; HEMODYNAMIC PROCESSES; HISTAMINE; HUMANS; HYDROCORTISONE; INFUSIONS, INTRAVENOUS; INTRAOPERATIVE CARE; MALE; MIDDLE AGED; OXYCODONE; POSTOPERATIVE CARE; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 11844272584     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2004.08.013     Document Type: Article

References (36)

1. Shafer S.L., Varvel J.R. Pharmacokinetics, pharmacodynamics and rational opioid selection. Anesthesiology. 74:1991;53-56
2. Howie M.B., Michelsen L.G., Hug C.C., et al. Comparison of three remifentanil dose-finding regimens for coronary artery surgery. J Cardiothorac Vasc Anesth. 17:2003;51-59
3. Patel H.H., Ludwig L.M., Fryer R.M., et al. Delta-opioid agonists and volatile anesthetics facilitate cardioprotection via potention of KATP channel opening. FASEB. 16:2003;1468-1470
4. Cao Z., Liu L., Van Winkle D.M. Activation of delta- and kappa-opioid receptors by opioid peptides protects cardiomyocytes via KATP channels. Am J Physiol Heart Circ Physiol. 285:2003;H1032-H1039
5. Eddy N.B., Halbach H., Braenden O.J. Synthetic substances with morphine-like effect. Bull Wld Hlth Org. 17:1975;569-863
6. Pöyhiä R., Seppälä T. Liposolubility and protein binding of oxycodone in vitro. Pharmacol Toxicol. 74:1994;23-27
7. Leow K.P., Wright A.W.E., Cramond T., et al. Determination of the serum protein binding of oxycodone and morphine using ultrafiltration. Ther Drug Monit. 15:1993;440-447
8. Ross F.B., Smith M.T. The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated. Pain. 73:1997;151-157
9. Yoburn B.C., Shah S., Chan K., et al. Supersensitivity to opioid analgesics following chronic opioid antagonist treatment Relationship to receptor selectivity. Pharmacol Biochem Behav. 51:1995;535-539
10. Pöyhiä R., Olkkola K.T., Seppälä T., et al. The pharmacokinetics of oxycodone after intravenous injection in adults. Br J Clin Pharmacol. 32:1991;516-518
11. Kalso E., Pöyhiä R., Onnela P., et al. Intravenous morphine and oxycodone for pain after abdominal surgery. Acta Anaesthesiol Scand. 35:1991;642-646
12. Pöyhiä R., Kalso E.A. Antinociceptive effects and central nervous system depression caused by oxycodone and morphine in rats. Pharmacol Toxicol. 70:1992;125-130
13. Kalso E., Vainio A. Morphine and oxycodone hydrochloride in the management of cancer pain. Clin Pharmacol Ther. 47:1990;639-646
14. Pöyhiä R., Kalso E., Seppälä T. Pharmacodynamic interactions of oxycodone and amitriptyline in healthy volunteers. Curr Ther Res. 51:1992;739-749
15. Gimbell J.S., Richards P., Portenoy R.K. Controlled-release oxycodone for pain in diabetic neuropathy A randomized controlled trial. Neurology. 60:2003;927-934
16. Kaplan R., Parris W.C., Citron M.I., et al. Comparison of controlled-release and immediate-release oxycodone tablets in patients with cancer pain. J Clin Oncol. 16:1998;3230-3237
17. Pöyhiä R. Opioids in anaesthesia A questionnaire survey in Finland. Eur J Anaesthesiol. 11:1994;221-230
18. Lahtinen P., Hendolin M., Kokki H., et al. Propacetamol as adjunctive treatment for postoperative pain after cardiac surgery. Anesth Analg. 95:2002;813-815
19. Gibaldi M., Perrier D. Pharmacokinetics. (ed 2):1982;Marcel Dekker, Inc, New York, NY
20. Hynynen M., Takkunen O., Salmenperä M., et al. Continuous infusion of fentanyl or alfentanil for coronary artery surgery. Br J Anaesth. 58:1986;1252-1259
21. Sanford T.J., Smith N.T., Dec-Silver H., et al. A comparison of morphine, fentanyl and sufentanil anesthesia for cardiac surgery induction, emergence and extubation. Anesth Analg. 65:1986;259-266
22. 2 anesthesia during cardiac surgery A comparison of cardiovascular profiles. J Cardiothorac Anesth. 2:1988;749-757
23. Welti R.S., Moldenhauer C.C., Hug C.C., et al. High-dose hydromorphone (Dilaudid) for coronary artery bypass surgery. Anesth Analg. 63:1984;55-59
24. Bovill J.G., Sebel P.S., Wauquier A., et al. Influence of high-dose alfentanil anaesthesia on the electroencephalogram Correlation with plasma concentrations. Br J Anaesth. 55:1983;199S-209S
25. Chi O.Z., Sommer W., Jasaitis D. Power spectral analysis of EEG during sufentanil infusion in humans. Can J Anaesth. 38:1991;275-280
26. Long C.W., Shah N.K., Loughlin C., et al. A comparison of EEG determinants of near-awakening from isoflurane and fentanyl anesthesia. Spectral edge, median power frequency and δ ratio. Anesth Analg. 69:1989;169-173
27. Sebel P.S., Bovill J.G., Wauquier A., et al. Effects of high-dose fentanyl anesthesia on the electroencephalogram. Anesthesiology. 55:1981;203-211
28. Heller S.S., Frank K.A., Malm J.R., et al. Psychiatric complications of open heart surgery. A re-examination. N Engl J Med. 283:1974;1015-1020
29. Quinlan D.M., Kimball C.P., Osborne F. The experience of open heart surgery IV. Assessment of disorientation and dysphoria following cardiac surgery. Arch Gen Psych. 31:1974;241-244
30. Horgan D., Davies B., Hunt D., et al. Psychiatric aspects of coronary artery surgery. A prospective study. Med J Aust. 141:1984;587-590
31. Bovill J.G., Sebel P.S., Stanley T.H. Opioid analgesics in anesthesia With special reference to their use in cardiovascular anesthesia. Anesthesiology. 61:1984;731-755
32. Pöyhiä R., Seppälä T., Olkkola K.T., et al. The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects. Br J Clin Pharmacol. 33:1992;617-621
33. Hughes M.A., Glass P.S.A., Jacobs J.R. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology. 76:1992;334-341
34. Kapila A., Glass P.S.A., Jacobs J.A., et al. Measured context-sensitive half-times of remifentanil and alfentanil. Anesthesiology. 83:1995;968-975
35. Schraag S., Mohl U., Hirsch M., et al. Recovery from opioid anesthesia The clinical implication of context-sensitive half-times. Anesth Analg. 86:1998;184-190
36. Philbin D.M., Rosow C.E., Schneider R.C., et al. Fentanyl and sufentanil anesthesia revisited How much is enough? Anesthesiology. 73:1990;5-11