Mild-phenotype sickle cell disease: Molecular basis, clinical presentation and management recommendations

Current Paediatrics

Volumn 15, Issue 1, 2005, Pages 57-61

  Adekile, Adekunle D ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Arab India haplotype; Hb F; Sickle cell disease; thalassaemia trait

Indexed keywords

BETA GLOBIN; HEMOGLOBIN F; PENICILLIN G;

ACUTE CHEST SYNDROME; ALPHA THALASSEMIA; CLINICAL FEATURE; HAPLOTYPE; HEREDITY; HUMAN; INHERITANCE; LEG ULCER; PHENOTYPE; PRIAPISM; PROPHYLAXIS; REVIEW; SICKLE CELL ANEMIA; SPLEEN DISEASE; STREPTOCOCCUS INFECTION; STROKE;

EID: 11844266551     PISSN: 09575839     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cupe.2004.10.009     Document Type: Article

References (19)

1. T.H. Huisman The structure and function of normal and abnormal haemoglobins D.J. Weatherall D.R. Higgs Bailliere's Clin Haematol vol. 6 1993 WB Saunders Company London 1 30
2. D.R. Powars The natural history of sickle cell anaemia The first 10 years Semin Hematol 12 1975 267 285
3. P.F. Milner, A.P. Krus, and J.I. Sebes. Sickle cell disease as a cause of osteonecrosis of the femoral head N Engl J Med 325 1991 1476 1481
4. K. Ohene-Frempong Stroke in sickle cell disease demographic, clinical, and therapeutic considerations Semin Hematol 28 1991 213 219
5. F.M. Gill, L.A. Sleeper, and S.J. Weiner Clinical events in the first decade in a cohort of infants with sickle cell disease Blood 86 1995 776 783
6. S gene Bailliere's Clin Haematol 5 1992 331 365
7. S. Charache Pharmacological modification of haemoglobin F expression in sickle cell anaemia an update on hydroxyurea studies Experientia 49 1993 126 131
8. S globin gene in Blacks the contribution of recurrent mutation or gene conversion or both Proc Natl Acad Sci USA 81 1984 853 856
9. S-globin gene cluster haplotypes as prognostic indicators of vital organ damage Semin Hematol 28 1991 202 208
10. D.R. Higgs, B.E. Aldridge, and J. Lamb The interaction of alpha-thalassaemia and homozygous sickle-cell disease N Engl J Med 306 1982 1441 1446
11. M.H. Steinberg, W. Rosenstock, and M.B. Coleman Effects of thalassaemia and microcytosis on the hematologic and vasoocclusive severity of sickle cell anaemia Blood 63 1984 1353 1360
12. S haplotypes among Kuwaiti Arabs Acta Haematol 92 1994 176 181
13. A.D. Adekile Sickle cell disease in Kuwait Hemoglobin 25 2001 219 225
14. A.D. Adekile, M. Tuli, and M.Z. Haider Influence of α-Thal trait on spleen function in sickle cell anaemia patients with high HbF Am J Hematol 53 1996 1 5
15. K. Ohene-Frempong, S.J. Weiner, and L.A. Sleeper Cerebrovascular accidents in sickle cell disease rates and risk factors Blood 91 1998 288 294
16. E. Mercuri, J.C. Faundez, and I. Roberts Neurological "soft" signs may identify children with sickle cell disease who are at risk for stroke Eur J Pediatr 154 1995 150 156
17. R. Marouf, R. Gupta, and M.Z. Haider Silent brain infarcts in adult Kuwaiti sickle cell disease patients Am J Hematol 73 2003 240 243
18. M. Raghavan, and S.C. Davies The management of haemoglobinopathies Curr Paediatr 12 2002 290 297
19. J.A. Finkelstein, S.S. Huang, and J. Daniel Antibiotic-resistant Streptococcus pneumoniae in the heptavalent pneumococcal conjugate vaccine era predictors of carriage in a multicommunity sample Paediatrics 112 2003 862 869