Benzodiazepines and injury: A risk adjusted model

Pharmacoepidemiology and Drug Safety

Volumn 14, Issue 1, 2005, Pages 17-24

  French, Dustin D ^a   Campbell, Robert ^b   Spehar, Andrea ^c   Angaran, David M ^d  

^a VISN 8 Measurement Support Team ^*  (United States)

^b VISN 8 Patient Safety Center   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Benzodiazepines; Patient safety; Practice guidelines; Risk adjustment; Wounds and injuries

Indexed keywords

ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE; CLONAZEPAM; CLORAZEPATE; DIAZEPAM; FLURAZEPAM; LORAZEPAM; OXAZEPAM; TEMAZEPAM; TRIAZOLAM;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DOSE RESPONSE; DRUG USE; FEMALE; HUMAN; INJURY; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PRESCRIPTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SIDE EFFECT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

AGE FACTORS; BENZODIAZEPINES; COMORBIDITY; DELIVERY OF HEALTH CARE; DRUG ADMINISTRATION SCHEDULE; DRUG UTILIZATION REVIEW; FEMALE; FLORIDA; HUMANS; MALE; MARITAL STATUS; MIDDLE AGED; MODELS, STATISTICAL; OUTPATIENTS; PHARMACOEPIDEMIOLOGY; RISK ADJUSTMENT; RISK FACTORS; UNITED STATES; UNITED STATES DEPARTMENT OF VETERANS AFFAIRS; WOUNDS AND INJURIES;

EID: 11844256384     PISSN: 10538569     EISSN: None     Source Type: Journal    
DOI: 10.1002/pds.967     Document Type: Article

References (55)

1. Ebly EM, Hogan DB, Fung TS. Potential adverse outcomes of psychotropic and narrotic drug use in Canadian seniors. J Clin Epidemiologyy 1997; 50: 857-863.
2. Kohn LT, Corrigan JM, Donaldson MS (eds). To Err is Human: Building a Safer Health System Committee on Quality of Health Care in America. Institute of Medicine, National Academy Press: Washington DC, 2000.
3. Castle SC. High Risk Medications and Falls: a Practical Approach to Risk Management. Presented at 3rd Annual Evidence-Falls Conference, 5 March 2002.
4. Smith RG. Fall-contributing adverse effects of the most frequently prescribed drugs. J Am Podiatr Med Assoc 2003; 93: 42-50.
5. Morrissey EFR, McElnay JC, Scott M, et al. Influence of drugs, demographics and medical history on hospital readmission of elderly patients: a predictive model. Clin Drug Invest 2003; 23 119-128.
6. Evans JG. Drugs and falls in later life. Lancet 2003; 361: 448.
7. Rizzo JA, Friedkin R, Williams CS, et al. Health care utilization and costs in a medicare population by fall status. Med Care 1998; 36: 1174-1188.
8. Fick DM, Waller JL, Maclean JR, et al. Potentially inappropriate medication use in a medicare managed care population: association with higher costs and utilization. J Managed Care Pharm 2001; 7: 407-413.
9. Neutel CI. Risk of traffic accident injury after a prescription for a benzodiazepine. Ann Epidemiol 1995; 5: 239-244.
10. Barbone F, McMahon AD, Davey PG, et al. Association of road-traffic accidents with benzodiazepine use. Lancet 1998; 24 1331-1336.
11. Oster G, Huse DM, Adams SF, et al. Benzodiazepine tranquilizers and the risk of accidental injury. Am J Public Health 1990; 80: 1467-1470.
12. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: part I and part II. J Amer Geriatr Soc 1999; 47: 30-50.
13. Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly: an update. Arch Intern Med 1997; 157: 1531-1536.
14. Weiner DK, Hanlon JT, Studenski SA. Effects of central nervous system polypharmacy on falls liability in community dwelling elderly. Gerontology 1998; 44: 217-221.
15. Schwab M, Roder F, Aleker T, et al. Psychotropic drug use, falls and hip fracture in the elderly. Aging (Milano) 2000; 12: 234-239.
16. Liu GG, Christensen DB. The continuing challenge of inappropriate prescribing in the elderly: an update of the evidence. J Am Pharm Assoc 2002; 42: 847-857.
17. Zhan C, Sangl J, Bierman AS, et al. Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditures Panel Survey. JAMA 2001; 286 2823-2829.
18. Hanlon JT, Fillenbaum G, Kuchibhatla M, et al. Inappropriate drug use, functional status decline, and mortality among community dwelling elderly. Gerontologist 2000; 40: 37.
19. Gandhi TK, Weingart SN, Borus J, et al. Adverse drug events in ambulatory care. NEJM 2003; 348: 1556-1564.
20. Tinetti ME, Liu WL, Claus EB. Predictors and prognosis of inability to get up after falls among elderly persons. JAMA 1993; 269: 65-70.
21. Cumming RG. Epidemiology of medication-related falls and fractures in the elderly. Drugs Aging 1998; 12: 43-53.
22. Koski K, Luukinen H, Laippala P, et al. Physiological factors and medications as predictors of injurious falls by elderly people: a prospective population-based study. Age Ageing 1996; 25: 29-38.
23. Neutel CI, Hirdes JP, Maxwell CJ, et al. New evidence on benzodiazepine use and falls: the time factor. Age Ageing 1996; 25: 273-278.
24. Grad R, Tamblyn R, Holbrook AM, et al. Risk of a new benzodiazepine prescription in relation to recent hospitalization. J Am Geriatr Soc 1999; 47: 184-188.
25. American Geriatrics Society (AGS) Panel. Guideline for the prevention of falls in older persons. JAGS 2001; 49: 664-672.
26. Jorm AF, Grayson D, Creasey H, et al. Long-term benzodiazepine use by elderly people living in the community. Aust N Z J Public Health 2000; 24: 7-10.
27. Rothschild JM, Bates DW, Leape LL. Preventable medical injuries in older patients. Arch Intern Med 2000; 160: 2717-2728.
28. Sleeper R, Bond CA, Rojas-Fernandez C. Psychotropic drugs and falls: new evidence pertaining to serotonin reuptake inhibitors. Pharmacotherapy 2000; 20: 308-317.
29. Herings RM, Stricker BH, de Boer A, et al. Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life. Arch Intern Med 1995; 155: 1801-1807.
30. Isacson D. Long-term benzodiazepine use: factors of importance and the development of individual use patterns over time - a 13-year follow-up in a Swedish community. Soc Sci Med 1977; 44 1871-1880.
31. Ray WA, Griffin MR, Downey W. Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA 1989; 262: 3303-3307.
32. Aston H. Guidelines for the rational use of benzodiazepines: when and what to use. Drugs 1994; 48: 25-38.
33. Wang PS, Bohn RL, Glynn RJ, et al. Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage and duration on risk of hip fracture. Am J Psychiatry 2001; 158: 892-898.
34. American Medical Association. International Classification of Diseases 9th Revision, Vol. 1. AMA Press: Chicago, IL, 2000; 200-217.
35. Honigman B, Light P, Pulling RM, et al. A computerized method for identifying incidents associated with adverse drug events in outpatients. Int J Med Inf 2001; 61: 21-32.
36. Nevitt MC, Cummings SR, Hudes ES. Risk factors for injurious falls: a prospective study. J Gerontol 1991; 46: M164-M170.
37. Tinetti M, Doucette J, Caus E, et al. Risk factors for serious injury during falls by older persons in the community. J Am Geriatr Soc 1995; 43: 1214-1221.
38. Iezzoni LI (ed.). Risk Adjustment for Measuring Health Care Outcomes, 2nd edn. Health Administration Press: Chicago, IL, 1997.
39. Elixhauser A, Steiner C, Harris DR, et al. Comorbidity measures for use with administrative data. Med Care 1998; 36: 8-27.
40. Fingerhut LA, Warner M. Injury Chart book. Health, United States, 1996-97. National Center for Health Statistics: Hyattsville, Maryland, 1997.
41. Ren XS, Skinner K, Lee A, et al. Social support, social selection and self-assessed health status: results from the veterans health study in the United States. Soc Sci Med 1999; 48: 1721-1734.
42. Seeman TE. Social ties and health: the benefits of social integration. Ann Epidemiol 1996; 6: 442-451.
43. Ostir GV, Simonsick E, Kasper JD, et al. Satisfaction with support given and its association with subsequent health status. J Aging Health 2002; 14: 355-369.
44. DuPertuis LL, Aldwin CM, Bosse R. Does the source of support matter for different health outcomes? Findings from the normative aging study. J Aging Health 2001; 13: 494-510.
45. Tinetti ME, McAvay G, Claus E. Does multiple risk factor reduction explain the reduction in fall rate in the Yale FICSIT Trial? Frailty and injuries cooperative studies of intervention techniques. Am J Epidemiol 1996; 144: 389-399.
46. Wei TS, Hu CH, Wang SH, Hwang KL. Fall characteristics, functional mobility and bone mineral density as risk factors of hip fracture in the community-dwelling ambulatory elderly. Osteoporos Int 2001; 12: 1050-1055.
47. Johnston JA, Wagner DP, Timmons S, et al. Impact of different measures of comorbid disease on predicted mortality of intensive care unit patients. Med Care 2002; 40: 929-940.
48. Stukenborg GJ, Wagner DP, Connors AF. Comparison of the performance of two comorbidity measures, with and without information from prior hospitalizations. Med Care 2001; 39: 727-739.
49. Pope GC. 'Diagnostic cost group hierarchical condition category models for medicare risk adjustment'. Final Report to the US Health Care Financing Administration under Contract No. 500-95-048. Health Economics Research, Inc.: Waltham, MA, December 2000.
50. Agresti A. Categorical Data Analysis, 2nd edn. John Wiley and Sons, Inc.: Hoboken, NJ, 2002.
51. SAS Language: Reference, Version 8, SAS Institute: Cary, NC, 2001.
52. Gray P, Hildebrand K. Fall risk factors in Parkinson's disease. J Neurosci Nurs 2000; 32: 222-228.
53. Van Doorn C, Gruber-Baldini AL, Zimmerman S, et al. Dementia as a risk factor for falls and fall injuries among nursing home residents. J AM Geriatr Soc 2003; 51: 1213-1218.
54. Ranson D. Epilepsy and trauma. J Law Med 2003; 10 265-266.
55. Shinoda-Tagawa T, Clark DE. Trends in hospitalizations after injury: are older women are displacing young men. Inj Prev 2003; 9: 214-219.