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1
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85196433395
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The name arose from the merge of the words indigo and oleum, meaning that it was isolated by treatment of the natural dye indigo with sulfuric acid / sulfuric anhydride mixture
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The name arose from the merge of the words indigo and oleum, meaning that it was isolated by treatment of the natural dye indigo with sulfuric acid / sulfuric anhydride mixture.
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10
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0034615797
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For recent reviews on the de novo construction of the indole nucleus, see among others
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For recent reviews on the de novo construction of the indole nucleus, see among others: Gribble G. W. J. Chem. Soc. Perkin Trans. 1, 2000, 1045-1075.
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Sundberg, R.J.1
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18
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0141741411
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For a wide literature on functionalization of indole nucleus see among others references cited
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For a wide literature on functionalization of indole nucleus see among others references cited in: Hartung, C.G.; Fecher, A., Chapell, B.; Snieckus V. Org. Lett., 2003, 5, 1899-1902.
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Bartoli, G.; Bosco, M.; Dalpozzo, R.; Grossi, L. Polar versus electron transfer pathway in the reaction of alkyl Grignard reagents with mononitroarenes. Factor affecting product distribution. In Paramagnetic Organometallic Species in Activation, Selectivity and Catalysis. Chanon, M; Juliard, M.; Poite, J.C.; eds. Kluwer Academic Publisher, Dordrecht, 1989, 489-502.
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Bartoli, G.; Bosco, M.; Dalpozzo, R.; Petrini, M. Tetrahedron, 1987, 43, 4221-4226.
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Barboni, L.; Bartoli, G.; Marcantoni, E.; Petrini, M.; Dalpozzo, R. J. Chem. Soc. Perkin Trans. 1, 1990, 2133-2138.
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In classical Grignard chemistry, this would constitute the normal addition, since electrophile was added to the freshly prepared organomagnesium. The inverse addition becomes the norm in the modern era when so many Grignard reagents are purchased
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In classical Grignard chemistry, this would constitute the normal addition, since electrophile was added to the freshly prepared organomagnesium. The inverse addition becomes the norm in the modern era when so many Grignard reagents are purchased.
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Actually, lower yields decreasing temperature badly joins with an SET mechanism, where lower temperatures should increase in-cage reactions and therefore addition over redox processes. Dobbs did not describe reaction product distribution. Other products arising from in-cage mechanism, such as anilines or diarylamines should be the by-products, which lowers yields. Nevertheless, Dobbs' results are in contrast with Harrowven's
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Actually, lower yields decreasing temperature badly joins with an SET mechanism, where lower temperatures should increase in-cage reactions and therefore addition over redox processes. Dobbs did not describe reaction product distribution. Other products arising from in-cage mechanism, such as anilines or diarylamines should be the by-products, which lowers yields. Nevertheless, Dobbs' results are in contrast with Harrowven's.
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