Endogenous interleukin-12 improves the early antimicrobial host response to murine Escherichia coli peritonitis

Shock

Volumn 23, Issue 1, 2005, Pages 54-58

  Weijer, Sebastiaan ^a   Florquin, Sandrine ^a   Van Der Poll, Tom ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Cytokines; Innate immunity; Mice; p35; Sepsis

Indexed keywords

INTERLEUKIN 12; PROTEIN P40; PROTEIN P75;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL PERITONITIS; BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ESCHERICHIA COLI; IMMUNE RESPONSE; INNATE IMMUNITY; KNOCKOUT MOUSE; LIVER HOMOGENATE; LIVER INJURY; LUNG INJURY; MOUSE; NONHUMAN; PERITONEAL FLUID LEVEL; SEPSIS;

ANIMALS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; INFLAMMATION; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PERITONITIS; SEPSIS; TIME FACTORS;

EID: 11444269210     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000150550.52962.2c     Document Type: Article

References (28)

1. Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A, Mercier JC, Offenstadt G, Regnier B: Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis. JAMA 274:968-974, 1995.
2. McClean KL, Sheehan GJ, Harding GK: Intraabdominal infection: a review. Clin Infect Dis 19:100-116, 1994.
3. Bosscha K, Reijnders K, Hulstaert PF, Algra A, van der Werken C: Prognostic scoring systems to predict outcome in peritonitis and intra-abdominal sepsis. Br J Surg 84:1532-1534, 1997.
4. Trinchieri G: Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133-146, 2003.
5. Puccetti P, Belladonna ML, Grohmann U: Effects of IL-12 and IL-23 on antigen-presenting cells at the interface between innate and adaptive immunity. Crit Rev Immunol 22:373-390, 2002.
6. Jansen PM, van der Pouw Kraan TC, de Jong IW, van Mierlo G, Wijdenes J, Chang AA, Aarden LA, Taylor FB Jr, Hack CE: Release of interleukin-12 in experimental Escherichia coli septic shock in baboons: relation to plasma levels of interleukin-10 and interferon-gamma. Blood 87:5144-5151, 1996.
7. Zisman DA, Kunkel SL, Strieter RM, Gauldie J, Tsai WC, Bramson J, Wilkowski JM, Bucknell KA, Standiford TJ: Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis. Shock 8:349-356, 1997.
8. Wysocka M, Kubin M, Vieira LQ, Ozmen L, Garotta G, Scott P, Trinchieri G: Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol 25:672-676, 1995.
9. Heinzel FP, Rerko RM, Ling P, Hakimi J, Schoenhaut DS: Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect Immun 62:4244-4249, 1994.
10. Mattner F, Ozmen L, Podlaski FJ, Wilkinson VL, Presky DH, Gately MK, Alber G: Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock. Infect Immun 65:4734-4737, 1997.
11. Leonard JP, Sherman ML, Fisher GL, Buchanan LJ, Larsen G, Atkins MB, Sosman JA, Dutcher JP, Vogelzang NJ, Ryan JL: Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 90:2541-2548, 1997.
12. Lauw FN, Dekkers PE, te Velde AA, Speelman P, Levi M, Kurimoto M, Hack CE, van Deventer SJ, van der Poll T: Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees. J Infect Dis 179:646-652, 1999.
13. Steinhauser ML, Hogaboam CM, Lukacs NW, Strieter RM, Kunkel SL: Multiple roles for IL-12 in a model of acute septic peritonitis. J Immunol 162:5437-5443, 1999.
14. Godshall CJ, Lentsch AB, Peyton JC, Scott MJ, Cheadle WG: STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis. Clin Diagn Lab Immunol 8:1044-1048, 2001.
15. Echtenacher B, Freudenberg MA, Jack RS, Mannel DN: Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis. Infect Immun 69:7271-7276, 2001.
16. Lankford CS, Frucht DM: A unique role for IL-23 in promoting cellular immunity. J Leukoc Biol 73:49-56, 2003.
17. Sewnath ME, Olszyna DP, Birjmohun R, ten Kate FJ, Gouma DJ, van der Poll T: IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance. J Immunol 166:6323-6331, 2001.
18. Weijer S, Sewnath ME, de Vos AF, Florquin S, van der Sluis K, Gouma DJ, Takeda K, Akim S, van der Poll T: Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis. Infect Immun 71:5488-5497, 2003.
19. Matsukawa A, Kaplan MH, Hogaboam CM, Lukacs NW, Kunkel SL: Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. J Exp Med 193:679-688, 2001.
20. Akira S: The role of IL-18 in innate immunity. Curr Opin Immunol 12:59-63, 2000.
21. Hochholzer P, Lipford GB, Wagner H, Pfeffer K, Heeg K: Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect Immun 68:3502-3508, 2000.
22. Netea MG, Fantuzzi G, Kullberg BJ, Stuyt RJ, Pulido EJ, McIntyre RC Jr, Joosten LA, Van der Meer JW, Dinarello CA: Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia. J Immunol 164:2644-2649, 2000.
23. Ono S, Ueno C, Seki S, Matsumoto A, Mochizuki H: Interleukin-12 and -18 induce severe liver injury in mice recovered from peritonitis after sublethal endotoxin challenge. Surgery 134:92-100, 2003.
24. Yao HW, Li J, Chen JQ: FR167653 attenuates murine immunological liver injury. World J Gastroenterol 10:2267-2271, 2004.
25. Hazelzet JA, Kornelisse RF, van der Pouw Kraan TC, Joosten KF, van der Voort E, van Mierlo G, Suur MH, Hop WC, de Groot R, Hack CE: Interleukin 12 levels during the initial phase of septic shock with purpura in children: relation to severity of disease. Cytokine 9:711-716, 1997.
26. Lauw FN, Simpson AJ, Prins JM, Smith MD, Kurimoto M, van Deventer SJ, Speelman P, Chaowagul W, White NJ, van der Poll T: Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis. J Infect Dis 180:1878-1885, 1999.
27. Oberholzer A, Harter L, Feilner A, Steckholzer U, Trentz O, Ertel W: Differential effect of caspase inhibition on proinflammatory cytokine release in septic patients. Shock 14:253-257, 2000.
28. Godshall CJ, Scott MJ, Burch PT, Peyton JC, Cheadle WG: Natural killer cells participate in bacterial clearance during septic peritonitis through interactions with macrophages. Shock 19:144-149, 2003.