4′-O-Alkyaloenin derivatives and their sulfates directed toward overcoming multidrug resistance in tumor cells

Cancer Letters

Volumn 218, Issue 1, 2005, Pages 15-20

  Jin, Guang Zhu ^a   Quan, Hong Ji ^a   Koyanagi, Jyunichi ^a   Takeuchi, Kazuhiro ^a   Miura, Yoshihiko ^a   Komada, Fusao ^a   Saito, Setsuo ^a  

^a JOSAI UNIVERSITY   (Japan)

Author keywords

4 O Alkylaloenin; 4 O Alkylaloenin sulfate; Cytotoxicity; HCT 116; Hep G2; P glycoprotein

Indexed keywords

ALKYL GROUP; ALLYL COMPOUND; ALOE ARBORESCENS EXTRACT; ALOENIN; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; PLANT EXTRACT; SULFATE; UNCLASSIFIED DRUG; COLORING AGENT; GLUCOSIDE; GLYCOPROTEIN P; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER RESEARCH; CANCER RESISTANCE; CELL STRAIN HCT116; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; GENE OVEREXPRESSION; HEP 2 CELL; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; MULTIDRUG RESISTANCE; NITROBLUE TETRAZOLIUM TEST; PRIORITY JOURNAL; STRUCTURE ANALYSIS; CELL CULTURE; CHEMISTRY; COLORECTAL TUMOR; DRUG RESISTANCE; DRUG SCREENING; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PATHOLOGY;

ALOE ARBORESCENS;

CARCINOMA, HEPATOCELLULAR; COLORECTAL NEOPLASMS; COLORING AGENTS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GLUCOSIDES; HUMANS; LIVER NEOPLASMS; P-GLYCOPROTEIN; SULFATES; TETRAZOLIUM SALTS; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 11444258244     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2004.07.025     Document Type: Article

References (16)

1. M.M. Gottensman, and I. Pasten Biochemistry of multidrug resistance mediated by the multidrug transporter Annu. Rev. Biochem. 62 1993 385 427
2. O. Fardel, V. Lecureur, and A. Guillonzo The P-glycoprotein multidrug transporter Gen. Pharmacol. 27 1996 1283 1291
3. M.M. Gottensman, T. Fojo, and S.E. Bates Multidrug resistance in cancer: role of ATP-dependent transporters Nat. Rev. Cancer 2 2002 48 58
4. R. Krishna, and L.D. Mayer Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs Eur. J. Pharm. Sci. 11 2000 265 283
5. D.R. Ferry, H. Traunecker, and D.J. Kerr Clinical trial of P-glycoprotein reversal in solid tumours Eur. J. Cancer 32A 1996 1070 1081
6. S. Saito, T. Furumoto, M. Ociai, A. Hosono, H. Hoshino, and U. Haraguchi Synthetic studies on the relationship between anti-HIV activities and micelle forming abilities of various alkylated glycyrrhetinate diglycoside sodium sulfates and related compounds Eur. J. Med. Chem. 31 1996 365 381
7. T. Mosmann Rapid colorimetric assay for cellular growth and survival; application to proliferation and cytotoxicity assays J. Immunol. Methods 139 1983 55 63
8. J.E. Hay, and L.J. Haynes The Aloins. Part I. The structure of barbaloin J. Chem. Soc. 1956 3141 3147
9. N. Okamura, N. Hine, S. Harada, T. Fujioka, K. Mihashi, and A. Yagi Three chromone components from Aloe Vera leaves Phytochemistry 43 1996 495 498
10. Th. J. De Boer, and H.J. Backer Diazomethane Org. Synth. IV 1963 250 253
11. K. Hayashi, Y. Nakanishi, K.F. Bastow, G. Cragg, H. Nozaki, and K.-H. Lee Anti tumor agents 221. Buceracidins A and B, two new flavanones from Bucida buceras J. Nat. Prod. 66 2003 125 127
12. C Log P values of derivatives in this study were calculated by ChemDraw Ultra 8.0 (CambridgeSoft, Cambridge Massachusetts, USA).
13. K. Iwase, M. Moriyasu, T. Yamori, T. Turuo, D.-U. Lee, and W. Wiegrebe In vitro Cytotoxicity of the Protoberberine-type Alkoloids. J. Nat. Prod. 64 2001 896 898
14. M. Shionoya, T. Jimbo, M. Kitagawa, T. Soga, and A. Tohogo DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo Cancer Sci. 94 2003 459 466
15. G. Lee, and M. Piqette-Miller Influence of IL-6 on MDR and MRP-mediated multidrug resistance in human hepatoma cells Can. J. Physiol. Pharmacol. 79 2001 876 884
16. (2+) antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression Eur. J. Pharm. Sci. 16 2002 159 165