Optimization of tumour control probability for heterogeneous tumours in fractionated radiotherapy treatment protocols

Physics in Medicine and Biology

Volumn 49, Issue 3, 2004, Pages 407-424

  Levin Plotnik, Daphne ^a   Hamilton, R J ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; OPTIMIZATION; PROBABILITY; RADIATION EFFECTS; RADIOTHERAPY; TUMORS;

RADIOSENSITIVITY; TUMOR CONTROL PROBABILITY (TCP);

BIOMEDICAL ENGINEERING;

ARTICLE; CANCER CONTROL; CANCER GROWTH; CANCER RADIOTHERAPY; CELL DENSITY; CLONOGENIC ASSAY; CONTROLLED STUDY; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; PROBABILITY; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; RADIOSENSITIVITY; SENSITIVITY AND SPECIFICITY; TUMOR VOLUME;

CELL DIVISION; CELL SURVIVAL; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NEOPLASM STAGING; NEOPLASMS; RADIOMETRY; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, CONFORMAL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 1142299662     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/49/3/005     Document Type: Article

References (19)

1. Brahme A and Agren A K 1987 Optimal dose distribution for eradication of heterogeneous tumours Acta Oncol. 26 377-85
2. Chao K S, Bosch R, Mutic S, Lewis J S, Dehdashti F, Mintun M A, Dempsey J F, Perez C A, Purdy J A and Welch M J 2001 A novel approach to overcome hypoxic tumor resistance: Cu-ATSM-guided intensity-modulated radiation therapy Int. J. Radiat. Oncol. Biol. Phys. 49 1171-82
3. Chappell R, Nondahl D M, Rezvani M and Fowler J F 1995 Further analysis of radiobiological parameters from the first and second British Institute of Radiology randomized studies of larynx/pharynx radiotherapy Int. J. Radiat. Oncol. Biol. Phys. 33 509-18
4. Ebert M A and Hoban P W 1996 Some characteristics of tumour control probability for heterogeneous tumours Phys. Med. Biol. 41 2125-33
5. Fowler J F 1991 The phantom of tumor treatment - continually rapid proliferation unmasked Radiother. Oncol. 22 156-8
6. Gelfand I M and Fomin S V 1963 Calculus of Variations (Englewood Cliffs, NJ: Prentice-Hall)
7. Hall E 2000 Radiobiology for the Radiologist 5th edn (Philadelphia: Lippincott Williams and Wilkins) p 390
8. Munro T R and Gilbert C W 1961 The relation between tumor lethal doses and the radiosensitivity of tumor cells Br. J. Radiol. 34 246-51
9. Petereit D G, Sarkaria J N, Chappell R, Fowler J, Hartmann T J, Kinsella T J, Stitt J A, Thomadsen B R and Buchler D A 1995 The adverse effect of treatment prolongation in cervical carcinoma Int. J. Radiat. Oncol. Biol. Phys. 32 1301-7
10. Roberts S A and Hendry J H 1998 A realistic closed-form radiobiological model of clinical tumour-control data incorporating intertumor heterogeneity Int. J. Radiat. Oncol. Biol. Phys. 41 689-99
11. Roberts S A and Hendry J H 1999 Time factors in larynx tumour radiotherapy: lag times and intertumor heterogeneity in clinical datasets from four centres Int. J. Radiat. Oncol. Biol. Phys. 45 1247-57
12. Stavreva N A, Stavrev P V and Round W H 1996 A mathematical approach to optimizing the radiation dose distribution in heterogeneous tumours Acta Oncol. 35 727-32
13. Tarnawski R, Fowler J, Skladowski K, Swierniak A, Suwinski R, Maciejewski B and Wygoda A 2002 How fast is repopulation of tumor cells during the treatment gap? Int. J. Radiat. Oncol. Biol. Phys. 54 229-36
14. Webb S and Nahum A E 1993 A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density Phys. Med. Biol. 38 653-66
15. Webb S, Evans P M, Swindel W and Deasy J O 1994 proof that uniform dose gives the greatest TCP for fixed integral dose in the planning target volume Phys. Med. Biol. 39 2091-98
16. Webb S 1994 Optimum parameters in a model for tumour-control probability including interpatient heterogeneity Phys. Med. Biol. 39 1895-914
17. Wyatt R M, Beddoe A H and Dale R G 2003 The effect of delays in radiotherapy on tumour control Phys. Med. Biol. 48 139-55
18. Xing L, Cotrutz C, Hunjan S, Boyer A L, Adalsteinsson E and Speilman D 2002 Inverse planning for functional image-guided intensity-modulated radiation therapy Phys. Med. Biol. 47 3567-78
19. Zaider M et al 2000 Treatment planning for prostate implants using magnetic-resonance spectroscopy imaging Int. J. Radiat. Oncol. Biol. Phys. 47 1085-96