Quantitative determination of p-aminosalicylic acid and its degradation product m-aminophenol in pellets by ion-pair high-performance liquid chromatography applying the monolithic Chromolith Speedrod RP-18e column

Biomedical Chromatography

Volumn 18, Issue 1, 2004, Pages 55-63

  Vasbinder, E ^a   van der Weken, G ^a   Vander Heyden, Y ^b   Baeyens, Willy R G ^a   Debunne, A ^a   Remon, J P ^a   Garcia Campana A M ^c  

^a GHENT UNIVERSITY   (Belgium)

^b PHARMACEUTICAL INSTITUTE   (Belgium)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Chromolith SpeedROD RP 18e; Ion pair reversed phase chromatography; m Aminophenol; Monolithic Column; p aminosalicylic acid; Pellets

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; DEGRADATION; DRUG DELIVERY; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION CHROMATOGRAPHY; IONS; PELLETIZING; SILICA;

CHROMOLITH SPEEDROD RP-18E; DEGRADATION PRODUCTS; ION-PAIR REVERSED-PHASE CHROMATOGRAPHY; M-AMINOPHENOL; MONOLITHIC COLUMNS; MONOLITHICS; P-AMINOSALICYLIC ACID; PACKING MATERIALS; PELLET; RUNTIMES;

SULFUR COMPOUNDS;

3 AMINOPHENOL; ACETANILIDE; AMINOSALICYLIC ACID; METHANOL; PHOSPHATE; SILICON DIOXIDE; SULFANILIC ACID; TETRABUTYLAMMONIUM;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; ION PAIR CHROMATOGRAPHY; PH; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; STANDARD; TEMPERATURE; TIME; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 1142299598     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.292     Document Type: Article

References (12)

1. Abdel-Fattah AM. Spectrophotometric determination of PAS in presence of its degradation product m-aminophenol. Pharmazie 1978; 33(7): 460.
2. Cabrera K, Lubda D, Eggenweiler H-M, Minakuchi H and Nakanishi K. A new monolithic-type HPLC column for fast separations. Journal of High Resolution Chromatography 2000; 23(1): 93-99.
3. Jivani SG and Stella VJ. Mechanism of decarboxylation of p-aminosalicylic acid. Journal of Pharmaceutical Science 1985; 74(12): 1274-1282.
4. Lubda D, Cabrera K, Kraas W, Schaefer C, Cunningham D and Majors RE. New developments in the application of monolithic HPLC columns. LC-GC Europe 2001; 12: 730-734.
5. Melvin JL, Bailey LC and Medwick T. Simultaneous dosage-form analysis of p-aminosalicylic acid and its degradation product m-aminophenol by high-performance liquid chromatography. Journal of Chromatographic Science 1981; 19: 146-150.
6. Shih IK. Analytical applications of p-nitrosobenzoic acid I: specific colorimetric determination of m-aminophenol in p-aminosalicylic acid ano sodium p-aminosalicylate. Journal of Pharmacecutical Science 1971; 60(12): 1853-1856.
7. Spell JC and Stewart JT. Quantitative analysis of para-aminosalicylic acid and its major impurity meta-aminophenol in para-aminosalicylic acid drug substance by HPTLC and scanning densitometry. Journal of Planar Chromatography 1994; 7: 472-473.
8. Tanaka N, Kobayashi H, Nakanishi K, Minakuchi H and Ishizuka N. Monolithic LC columns. Analytical Chemistry 2001; 73: 421A-429A.
9. Tanaka N, Nagayama H, Kobayashi H, Ikegami T, Hosoya K, Ishizuka N, Minakuchi H, Nakanishi K, Cabrera K and Lubda D. Monolithic silica columns for HPLC, Micro-HPLC, and CEC. Journal of High Resolution Chromatography 2000; 23(1): 111-116.
10. Vander Heyden Y, Nijhuis A, Smeyers-Verbeke J, Vandeginste BGM and Massart DL. Guidance for robustness/ruggedness tests in method validation. Journal of Pharmaceutical and Biomedical Analysis 2001; 24: 723-753.
11. Vetuschi C, Ragno G and Mazzeo P. Determination of p-aminosalicylic acid and m-aminophenol by derivative UV-spectrometry. Journal of Pharmaceutical and Biomedical Analysis 1988; 6(4): 383-391.
12. Zöllner P, Leitner A, Lubda D, Cabrera K and Lindner W. Application of a Chromolith SpeedROD RP-18e HPLC column: determination of ochratoxin A in different wines by high-performance liquid chromatography - tandem mass spectrometry. Chromatographia 2000; 52(11/12): 818-820.