Protective effect of a polyherbal drug, ambrex in ethanol-induced gastric mucosal lesions in experimental rats

Indian Journal of Pharmacology

Volumn 36, Issue 1, 2004, Pages 34-37

  Narayan, S ^a   Devi, R S ^a   Jainu, M ^a   Sabitha, K E ^a   Shyamala Devi, C S ^a,b  

^a UNIVERSITY OF MADRAS   (India)

^b NONE   (India)

Author keywords

Alcohol; Alkaline phosphatase; Gastric ulcer

Indexed keywords

ALCOHOL; ALKALINE PHOSPHATASE; AMBER FOSSIL EXTRACT; AMBREX; CYCAS CIRCINALIS EXTRACT; DNA; HERBACEOUS AGENT; ORCHIS MASCULA EXTRACT; SHOREA ROBUSTA EXTRACT; UNCLASSIFIED DRUG; WITHANIA SOMNIFERA EXTRACT;

AMBER FOSSIL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYCAS CIRCINALIS; DNA CONTENT; DRUG EFFICACY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; MALE; MEDICINAL PLANT; NONHUMAN; ORCHIS MASCULA; RAT; RAT STRAIN; SHOREA ROBUSTA; STOMACH MUCOSA LESION; STOMACH ULCER; WITHANIA SOMNIFERA;

EID: 1142275219     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Goel RK, Chakrabarthy A, Sanyal AK. The effect of biological variables on the antiulcerogenic effect of vegetable plantain banana. Planta Medica 1985;2:85-8.
2. Barrowman JA, Pfeiffer CJ. Carbenoxolone: A critical analysis of its clinical value in peptic ulcer. In: Pfeiffer CJ, editor. Drugs and Peptic Ulcer. Boca Raton: CRL Press; 1982. p. 123-32.
3. Shetty R, Kumar KV, Naidu MUR, Ratnakar KS. Effect of Gingko biloba extract on ethanol-induced gastric mucosal lesions in rats. Indian J Pharmacol 2000;32:313-7.
4. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Indian J Exp Biol 1997;35:236-9.
5. Prakash J, Gupta SK, Kochupillai V, Singh N, Gupta YK, Joshi S. Chemopreventive activity of Withania somnifera in experimentally induced fibrosarcoma tumours in Swiss albino mice. Phytother Res 2001;15: 240-4.
6. Vaidyaratnam PSV. Indian Medicinal Plants. In: Warder PK, Nambiar VPK, Ramankutty C, editors. 1st ed. Chennai: Orient Longman Ltd; 1997. Vol 2. p. 272.
7. Nadkarni KM. Indian plants and drugs with their medicinal properties and uses. 1st ed. Delhi: Asiatic Publishing House; 2001. Vol 1.
8. Vaidyaratnam PSV. Indian Medicinal Plants. In: Warder PK, Nambiar VPK, Ramankutty C, editors. 1st ed. Chennai: Orient Longman Ltd.; 1997. Vol 5. p. 124.
9. Parrotta JA. Healing plants of peninsular India. 1st ed. New York: CABI publishing; 2001. Vol 1.
10. Nadkarni KM. Indian Materia Medica. 1st ed. Bombay: Popular Prakashan Pvt. Ltd.; 1976. Vol 1.
11. Pihan G, Regillo C, Szabo S. Free radical and lipid peroxidation in ethanol or aspirin-induced gastric mucosal injury. Dig Dis Sci 1987;32:1395-401.
12. 2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats. Arch Int Pharmacodyn 1984; 275:123-38.
13. Lowry OH, Rosebrough NJ, Lewisfarr A, Randall RJ. Protein measurements with the folin phenol reagent. J Biol Chem 1951;193:265-75.
14. Bregman AA. Laboratory Investigation and Cell Biology. NewYork: John Wiley; 1983.
15. Kind PRN, King EJ. Determination of serum alkaline phosphatase. Clin Path 1954;7:322.
16. Martin MJ, Marhuenda ME, Perez-Guerrero C, Franco JM. Antiulcer effect of naringin on gastric lesions induced by ethanol in rats. Pharmacology 1994;49:144-50.
17. Al-Harbi MM, Quershi S, Raza M, Ahmed, MM, Afzal M, Shah AH. Gastric antiulcer and cytoprotective effect Commiphora molmol in rats. J Ethnopharmacol 1997;55:141-50.
18. Vanisree AJ, Mitra K, Shyamala Devi CS. Antiulcerogenic effect of UL-409 against experimentally induced gastric ulcer in rats. Indian J Pharmacol 1996;28:265-8.
19. Hollander D, Taranawski A, Gergely H, Zipser KD. Sucralfate protection of the gastric mucosa against alcohol - induced injury: A prostaglandin-mediated process. Scand J Gastroenterol 1984;101:97-102.
20. Miller TA, Henagan JM. Indomethacin decreases resistance of gastric barrier disruption by alcohol. Dig Dis Sci 1984;29:141-9.
21. Glavin GB, Szabo S. Experimental gastric mucosal injury: Laboratory models reveal machanisms of pathogenesis and new therapeutic strategies. FASEB J 1992;6:825-31.
22. Tepperman BL, Soper BD. Effect of sialoadenectomy on ethanol induced gastric mucosal damage in rat: Role of neutrophils. Canad J Physiol Pharmocol 1990;68:207-10.
23. Anjali J, Bhartiya HP, Vishwakarma AN. A chalcone glycoside from the heart-wood of Shorea robusta. Phytochemistry 1982;21:957.
24. Ebadi M. Pharmacodynamic basis of herbal medicine. In: Flavonoids, editor. New York: CRC Press; 2002.
25. Ferguson WW, Starling JR, Wangensteen SL. Role of lysosomal enzyme release in the pathogenesis of stress - induced gastric ulceration. Surg Forum 1972;23:380-2.