Significance of trypsin inhibitor gene mutation in the predisposition to pancreatitis

International Congress Series

Volumn 1255, Issue C, 2003, Pages 41-48

  Hirota, Masahiko ^a   Kuwata, Kinuko ^a   Ohmuraya, Masaki ^a   Ogawa, Michio ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic pancreatitis; Hereditary pancreatitis; PSTI; SPINK1; Trypsin

Indexed keywords

EID: 11244332670     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0531-5131(03)00195-X     Document Type: Article

References (11)

1. Y. Kimura, M. Hirota, K. Inoue, K. Kuwata, M. Ohmuraya, K. Maeda, M. Ogawa, Activation of protease-activated receptor 2 signals contributes to the cytokine production in acute pancreatitis. Manuscript in this proceedings.
2. M. Ogawa, M. Hirota, K. Kuwata, Genetic mutations in pancreatic secretory trypsin inhibitor (PSTI) gene in patients with pancreatitis. Reported at the annual meeting of research committee for intractable pancreatic diseases in Japan on September 9th, 1999.
3. Kuwata, K., Hirota, M., Sugita, H., Kai, M., Hayashi, M., Nakamura, M., Matsuura, T., Adachi, N., Nishimori, I., Ogawa, M., Genetic mutations in exons 3 and 4 of the pancreatic secretory trypsin inhibitor in patients with pancreatitis. J. Gastroenterol. 36 (2001), 612–618.
4. Witt, H., Luck, W., Hennies, H.C., Classen, M., Kage, A., Lass, U., Landt, O., Mutations in the gene encoding the serine protease inhibitor, Kazal type I are associated with chronic pancreatitis. Nat. Genet. 25 (2000), 213–216.
5. Pfutzer, R.H., Barmada, M.M., Brunskill, A.P., Finch, R., Hart, P.S., Neoptolemos, J., Furey, W.F., Whitcomb, D.C., SPINK/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology 119 (2000), 615–623.
6. Kaneko, K., Nagasaki, Y., Furukawa, T., Mizutamari, H., Sato, A., Masamune, A., Shimosegawa, T., Horii, A., Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis. J. Hum. Genet. 46 (2001), 293–297.
7. Chen, J.M., Mercier, B., Audrezet, M.P., Raguenes, O., Quere, I., Ferec, C., Mutations of the pancreatic secretory trypsin inhibitor (PSTI) gene in idiopathic chronic pancreatitis. Gastroenterology 120 (2001), 1061–1063.
8. K. Kuwata, M. Hirota, I. Nishimori, M. Otsuki, M. Ogawa, Mutational analysis of the pancreatic secretory trypsin inhibitor (PSTI) gene in familial and juvenile pancreatitis in Japan. J. Gastroenterol. (in press).
9. Kuwata, K., Hirota, M., Shimizu, H., Nakae, M., Nishihara, S., Takimoto, A., Mitsushima, K., Kikuchi, N., Endo, S., Inoue, M., Ogawa, M., Functional analysis of recombinant pancreatic secretory trypsin inhibitor proteins with amino acid substitution. J. Gastroenterol 87 (2002), 928–934.
10. Poiesi, C., Albertini, A., Ghielmi, S., Cassani, G., Corti, A., Kinetic analysis of TNF-alpha oligomer–monomer transition by surface plasmon resonance and immunochemical methods. Cytokine 5 (1993), 539–545.
11. M. Ohmuraya, K. Hirokawa, M. Araki, K. Araki, M. Hirota, M. Ogawa, K. Yamamura, Generation of pancreatic secretory trypsin inhibitor gene knockout mice. Manuscript in this proceedings.