Changes in thymopoiesis in myasthenia gravis

International Journal of Neuroscience

Volumn 115, Issue 2, 2005, Pages 223-243

  Kosec, Duško ^a   Lavrnić, Dragana ^b   Apostolski, Slobodan ^b   Leposavić, Gordana ^a,c,d  

^a Immunology Research Center Belgrade   (Yugoslavia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

^c Faculty of Pharmacy   (Serbia)

^d School of Pharmacy   (Serbia)

Author keywords

Immunoregulatory cells; Myasthenia gravis; T cell maturation

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

APOPTOSIS; ARTICLE; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERPLASIA; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; MYASTHENIA GRAVIS; PHENOTYPE; T LYMPHOCYTE; THYMOCYTE; THYMUS;

EID: 11244318428     PISSN: 00207454     EISSN: None     Source Type: Journal    
DOI: 10.1080/00207450590519472     Document Type: Article

References (38)

1. Aime, C., Cohen-Kaminsky, S., & Berrih-Aknin, S. (1991). In vitro interleukin-1 (IL-1) production in thymic hyperplasia and thymoma from patients with myasthenia gravis. Journal of Clinical Immunology, 11(5), 268-278.
2. Berrih-Aknin, S., Morel, E., Gaud, C., Raimond, F., Le Brigand, H., & Bach, J. P. (1984). Anti-AChR antibodies, thymic histology, and T cell subsets in myasthenia gravis. Neurology, 34(1), 66-71.
3. Berrih-Aknin, S., Cohen-Kiminsky, S., Neumann, D., Safar, D., Eymard, B., Gaud, C., Levasseur, D., Fuels, S., & Bach, J. F. (1988). Cellular aspects of myasthenia gravis. Immunological Research, 7(3), 189-199.
4. Budd, R. C., & Mixter, P. F. (1995). The origin of CD4-CD8-TCRαβ thymocytes: A model based on T-cell receptor avidity. Immunology Today, 16(9), 428-431.
5. Capone, M., Hockett, R. D. Jr., & Zlotnik, A. (1998). Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes. Proceedings of the National Academy of Science USA, 95(21), 12522-12527.
6. Chan, S. H., Cosgrove, D., Waltzinger, C., Benoist, C., & Mathis, D. (1993). Another view of the selective model of thymocyte selection. Cell, 73(2), 225-236.
7. Christadoss, P., Lindstrom, J. M., Melvold, R. W., & Talal, N. (1985). Mutation of I-Abeta chain prevents experimental myasthenia gravis. Journal of Immunogenetics, 21(1), 31-38.
8. Fridkis-Hareli, M., Eren, R., Sharp, A., Abel, L., Kukulansky, T., & Globerson, A. (1993). MHC recognition in colonization of the thymus by bone marrow cells. Cellular Immunology, 149(1), 91-98.
9. Fuji, N., Itoyama, Y., & Goto, I. (1990). Increase in differentiated type of T lineage cells in the myasthenic thymus: Two-color fluorocytometric analysis. Annals of Neurology, 27(2), 642-646.
10. Fukuhara, K., Okumura, M., Shiono, H., Inoue, M., Kadota, Y., Miyashi, S., & Matsuda, H. (2002). A study on CD45 isoform expressed during T-cell development and selection events in the human thymus. Human Immunology, 63(5), 394-404.
11. Ichikawa, Y., Shimizu, H., Yoshida, M., & Arimori, S. (1992). Two-color flow cytometric analysis of thymic lymphocytes from patients with myashenia gravis and/or thymoma. Clinical Immunology Immunopathology, 62(1Pt), 91-96.
12. Jameson, S. C., Hogquist, K. A., & Bevan, M. J. (1995). Positive selection of thymocytes. Annual Review of Immunology, 13, 93-126.
13. Kaul, R., Shenoy, M., Goluszko, E., & Christadoss, P. (1994). Major histocompatibility complex class II gene disruption prevents experimental autoimmune myasthenia gravis. Journal of Immunology, 152(6), 3152-3157.
14. Lee, P. T., Benlagha, K., Teyton, L., & Bendelac, A. (2002). Distinct functional lineages of human Vα24 natural killer T cells. Journal of Experimental Medicine, 195(5), 637-641.
15. Leprince, C., Cohen-Kaminsky, S., Berrih-Aknin, S., Vernet Der Garabedian, B., Treton, D., Galanaud, P., & Richard, Y. (1990). Thymic B cells from myasthenia gravis patients are activated B cells: Phenotypic and functional analysis. Journal of Immunology, 145(7), 2115-2122.
16. Levine, G., & Rosai, J. (1978). Thymic hyperplasia and neoplasia: A review of current concepts. Human Pathology, 9(5), 495-515.
17. Lind, E. F., Prockop, S. E., Porritt, H. E., & Petrie, H. T. (2001). Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development. Journal of Experimental Medicine, 194(2), 127-134.
18. MacDonald, H. R., Radtke, F., & Wilson, A. (2001). T cell fate specification and alfa-beta/gamma-delta lineage commitment. Current Opinion in Immunology, 13(2), 219-224.
19. Mehr, R., Perelson, A. S., Fridkis-Hareli, M., & Globerson, A. (1997). Regulatory feedback pathways in the thymus. Immunology Today, 18(12), 581-585.
20. Molinar, S., & Szobor, A. (1990). Myasthenia gravis: Effect of thymectomy in 425 patients; a 15-year experience. European Journal of Cardiothorac Surgery, 4(1), 8-14.
21. Mower, D. A., Peckham, D. W., Illera, V. A., Fishbaugh, J. K., Stunz, L. L., & Ashman, R. F. (1994). Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis. Journal of Immunology, 152(10), 4832-4842.
22. Osserman, K. E., & Genkins, G. (1971). Studies in myasthenia gravis: Review of twenty-year experience in over 1200 patients. Mount Sinai Journal of Medicine, 38(6), 497-537.
23. Papiernik, M., de Moraes, M. L., Pontoux, C., Vasseur, F., & Penit, C. (1998). Regulatory CD4 T cells: Expression of IL-2R α-chain, resistance to clonal deletion and IL-2 dependency. International Immunology, 10(4), 371-378.
24. Petrie, H. T., Hugo, P., Scollay, R., & Shortman, K. (1990). Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4 and CD8 acquisition in vivo and in vitro. Journal of Experimental Medicine, 172(6), 1583-1588.
25. Ragheb, S., & Lisak, R. P. (1994). The immunopathogenesis of acquired (autoimmune) myasthenia gravis. In S. Ragheb & R. P. Lisak (Ed.), Handbook of myasthenia gravis and myasthenic syndromes (pp. 239-276). New York: Dekker.
26. Reinhardt, C., & Melms, A. (2000). Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. Annals of Neurology, 48(4), 603-608.
27. Roncarolo, M. G., & Levings, M. K. (2000). The role of different subsets of T regulatory cells in controlling autoimmunity. Current Opinion in immunology, 12(6), 676-683.
28. Salakou, S., Tsamandas, A. C., Bomkos, D. S., Papapetropoulos, T., & Dougenis, D. (2001). The potential role of bcl-2, bax and Ki67 expression in thymus of patient with myasthenia gravis and their correlation with clinicopathological parameters. European Journal of Cardiothorac Surgery, 20(4), 712-721.
29. Schönbeck, S., Padberg, F., Hohfield, R., & Wekerle, H. (1992). Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. Journal of Clinical Investigations, 90(1), 245-250.
30. Scollay, R., & Godfrey, D. I. (1995). Thymic emigration: Conveyor belts or lucky dips? Immunology Today, 16(6), 268-273.
31. Seddon, B., & Mason, D. (2000). The third function of the thymus. Immunology Today, 21(2), 95-99.
32. Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003). Positive and negative selection of T cells. Annual Review of Immunology, 21, 139-176.
33. Taams, L. S., & Wauben, H. M. (2000). Anergic T cells as active regulators of immune response. Human Immunology, 61(1), 633-639.
34. von Boehmer, H., Aifantis, I., Feinberg, J., Lechner, O., Saint-Ruf, C., Walter, U., Buer, J., & Azogui, O. (1999). Pleiotropic changes controlled by the pre-T-cell receptor. Current Opinion in Immunology, 11(2), 135-142.
35. Wallace, V. A., Fung-Leung, W. P., Timms, E., Grey, D., Kishihara, K., Loh, D. Y., Penninger, J., & Mak, T. W. (1992). CD45RA and CD45RB high expression induced by thymic selection events. Journal of Experimental Medicine, 176(6), 1654-1663.
36. Wallace, V. A., Penninger, J. M., Kishihara, K., Timms, E., Shahinian, A., Pircher, H., Kündig, T. M., Ohashi, P. S., & Mak, T. W. (1997). Alterations in the level of CD4S surface expression affect outcome of thymic selection. Journal of Immunology, 158(7), 3205-3214.
37. Wang, R., Wang-Zhu, Y., & Grey, H. (2002). Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity. Proceedings of the National Academy of Science USA, 99(4), 2181-2186.
38. Westermann, J., Smith, T., Peters, U., Tschernig, T., Pabst, R., Steinhoff, G., Sparshott, S. M., & Bell, E. B. (1996). Both activated and non-activated leucocytes from the periphery continuously enter the thymic medulla of adult rats: Phenotypes, source and magnitude of traffic. European Journal of Immunology, 26(8), 1866-1874.