Retention behavior of metformin and related impurities in ion-pairing liquid chromatography

Journal of Liquid Chromatography and Related Technologies

Volumn 28, Issue 1, 2005, Pages 81-95

  David, Victor ^a   Medvedovici, Andrei ^a   Albu, Florin ^b  

^a UNIVERSITY OF BUCHAREST   (Romania)

^b LaborMed Pharma SA   (Romania)

Author keywords

HPLC DAD; Ion pair mechanism; Metformin; Related impurities; Retention model

Indexed keywords

CORRELATION METHODS; DATA REDUCTION; DIODES; IMPURITIES; PARTICLE SIZE ANALYSIS; PH EFFECTS; THERMODYNAMICS;

DIODE-ARRAY-DETECTORS (DAD); LIMIT OF QUANTITATION (LOQ); METFORMINS; THERMODYNAMIC PARAMETERS;

LIQUID CHROMATOGRAPHY;

1 METHYLBIGUANIDINE; 4,6 DIAMINO 1,3,5 TRIAZIN 2 YLGUANIDINE; ACETONITRILE; DICYANODIAMIDE; GUANIDINE DERIVATIVE; MELAMINE; METFORMIN; N,N DIMETHYLMELAMINE; OCTANE; SODIUM OCTANESULFONATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; DIODE; DIODE ARRAY DETECTOR; DRUG DETERMINATION; DRUG IMPURITY; DRUG RETENTION; ELUTION; ENTHALPY; ENTROPY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION PAIR CHROMATOGRAPHY; PARTICLE SIZE; PARTITION COEFFICIENT; PH MEASUREMENT; PHASE TRANSITION; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; THERMODYNAMICS;

EID: 11244311773     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-200038592     Document Type: Article

References (17)

1. European Pharmacopoeia; Supplement 4.4, 2003, Council of Europe: Strasbourg, 3470-3471.
2. Habib, I.H.I, and Kamal, M.S. (2003) Near infra-red reflectance spectroscopic determination of metformin in tablets. Talanta, 60: 185-190.
3. Wang, Z.P., Zhang, Z.H., Fu, Z.F., Luo, W.F., and Zhang, X. (2003) Sensitive flow-injection chemiluminescence determination of metformin based on N-bromo-succinimide-fluorescein system. Anal. Lett., 36: 2683-2697.
4. Ohta, M., Iwasaki, M., Kai, M., and Ohkura, Y. (1993) Determination of a biguanide, metformin, by high-performance liquid chromatography with precolumn fluorescence derivatization. Anal. Sci., 9: 217-220.
5. Cheng, C.L. and Chou, C.H. (2001) Determination of metformin in human plasma by high-performance liquid chromatography with spectrometric detection. J. Chromatogr. B, 762: 51-58.
6. Tache, F., David, V., Farca, A., and Medvedovici, A. (2001) HPLC-DAD determination of metformin in human plasma using derivatization with p-nitrobenzoyl chloride in a biphasic system. Microchem. J., 68: 13-19.
7. AbuRuz, S., Millership, J., and McElnay, J. (2003) Determination of metformin in plasma using a new ion pair solid phase extraction technique and ion pair liquid chromatography. J. Chromatogr. B, 798: 203-209.
8. Dorsey, J.G. and Dill, K.A. (1989) The molecular mechanism of retention in reversed-phase liquid chromatography. Chem. Rev., 89: 331-346.
9. Miyabe, K. and Guiochon, G. (2002) Extrathermodynamic relationships in reversed-phase liquid chromatography. Anal. Chem., 74: 5754-5765.
10. Espinoza, S., Bosch, E., and Roses, M. (2000) Retention of ionizable compounds in high-performance liquid chromatography. IX. Modeling retention in reversed-phase liquid chromatography as a function of pH and solvent composition with acetonitrile-water mobile phases. Anal. Chem., 72: 5193-5200.
11. Espinoza, S., Bosch, E., and Roses, M.J. (2002) Retention of ionizable compounds on HPLC. 5. pH scales and the retention of acids and bases with acetonitrile-water mobile phases. J. Chromatogr. A, 947: 47-58.
12. Bartha, A. and Stahlberg, J. (1994) Electrostatic retention model of reversed-phase ion-pair chromatography. J. Chromatogr. A, 668: 255-284.
13. David, V., Albu, F., and Medvedovici, A. (2004) Retention-structure correlation of some oxicame drugs in reversed-phase liquid chromatography. J. Liquid Chromatogr. Relat. Technol, 27: 965-984.
14. www.chemsilico.com/CS_products/products.html.
15. Meylan, W.M. and Howard, P.H. (1995) Atom/fragment contribution method for estimating octanol-water partition coefficients. J. Pharm. Sci., 84: 83-92.
16. Miller, J.N. (1991) Basic statistical methods for analytical chemistry. Part 2. Calibration and regression methods. Analyst, 116: 3-14.
17. Vander Heyden, Y., Nijhuis, A., Smeyers-Verbeke, J., Vandeginste, B.G.M., and Massart, D.L. (2001) Guidance for robustness/ruggedness tests in method validation. J. Pharm. Biomed. Anal., 24: 723-753.