Dose-dependent inhibition of thyroid differentiation by RAS oncogenes

Molecular Endocrinology

Volumn 19, Issue 1, 2005, Pages 76-89

  De Vita, Gabriella ^a   Bauer, Lisa ^a   Correa Da Costa, Vania M ^a,b   De Felice, Mario ^a   Baratta, Maria Giuseppina ^a   De Menna, Marta ^a   Di Lauro, Roberto ^a  

^a STAZIONE ZOOLOGICA ANTON DOHRN   (Italy)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; RAS PROTEIN; TAMOXIFEN; THYROTROPIN;

ANIMAL CELL; ARTICLE; CELL LINE; CONCENTRATION RESPONSE; GENE EXPRESSION; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; THYROID CELL; THYROID GLAND;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION; NUCLEAR PROTEINS; ONCOGENE PROTEIN P21(RAS); PAIRED BOX TRANSCRIPTION FACTORS; RATS; TAMOXIFEN; THYROGLOBULIN; THYROID GLAND; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 11244287542     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2004-0172     Document Type: Article

References (43)

1. Bos JL 1989 ras Oncogenes in human cancer: a review. Cancer Res [Erratum 50:1352 (1990)] 49:4682-4689
2. Tallini G 2002 Molecular pathobiology of thyroid neoplasms. Endocr Pathol 13:271-288
3. Lemoine NR, Mayall ES, Wyllie FS, Williams ED, Goyns M, Stringer B, Wynford-Thomas D 1989 High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis. Oncogene 4:159-164
4. Namba H, Rubin SA, Fagin JA 1990 Point mutations of ras oncogenes are an early event in thyroid tumorigenesis. Mol Endocrinol 4:1474-1479
5. Gimm O 2001 Thyroid cancer. Cancer Lett 163:143-156
6. Garcia-Rostan G, Zhao H, Camp RL, Pollan M, Herrero A, Pardo J, Wu R, Carcangiu ML, Costa J, Tallini G 2003 ras Mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer. J Clin Oncol 21:3226-3235
7. Sherman SI 2003 Thyroid carcinoma. Lancet 361:501-511
8. Ambesi-Impiombato FS, Parks LA, Coon HG 1980 Culture of hormone-dependent functional epithelial cells from rat thyroids. Proc Natl Acad Sci USA 77:3455-3459
9. Missero C, Cobellis G, De Felice M, Di Lauro R 1998 Molecular events involved in differentiation of thyroid follicular cells. Mol Cell Endocrinol 140:37-43
10. Dupuy C, Pomerance M, Ohayon R, Noel-Hudson MS, Deme D, Chaaraoui M, Francon J, Virion A 2000 Thyroid oxidase (THOX2) gene expression in the rat thyroid cell line FRTL-5. Biochem Biophys Res Commun 277:287-292
11. Royaux IE, Suzuki K, Mori A, Katoh R, Everett LA, Kohn LD, Green ED 2000 Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. Endocrinology 141:839-845
12. Fusco A, Berlingieri MT, Di Fiore PP, Portella G, Grieco M, Vecchio G 1987 One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes. Mol Cell Biol 7:3365-3370
13. Francis-Lang H, Zannini M, De Felice M, Berlingieri MT, Fusco A, Di Lauro R 1992 Multiple mechanisms of interference between transformation and differentiation in thyroid cells. Mol Cell Biol 12:5793-5800
14. Missero C, Pirro MT, Di Lauro R 2000 Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1. Mol Cell Biol 20:2783-2793
15. Morgenstern JP, Land H 1990 Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 18:3587-3596
16. Shirokawa JM, Elisei R, Knauf JA, Hara T, Wang J, Saavedra HI, Fagin JA 2000 Conditional apoptosis induced by oncogenic ras in thyroid cells. Mol Endocrinol 14:1725-1738
17. Samuels ML, Weber MJ, Bishop JM, McMahon M 1993 Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol 13:6241-6252
18. Greulich H, Erikson RL 1998 An analysis of Mek1 signaling in cell proliferation and transformation. J Biol Chem 273:13280-13288
19. Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R, Zannini M 2003 The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem 278:3395-3402
20. Gire V, Wynford-Thomas D 2000 RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation. Oncogene 19:737-744
21. Kupperman E, Wofford D, Wen W, Meinkoth JL 1996 Ras inhibits thyroglobulin expression but not cyclic adenosine monophosphate-mediated signaling in Wistar rat thyrocytes. Endocrinology 137:96-104
22. Velasco JA, Acebron A, Zannini M, Martin-Perez J, Di Lauro R, Santisteban P 1998 Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation. Endocrinology 139:2796-2802
23. Crespo P, Leon J 2000 Ras proteins in the control of the cell cycle and cell differentiation. Cell Mol Life Sci 57:1613-1636
24. Malumbres M, Barbacid M 2003 RAS oncogenes: the first 30 years. Nat Rev Cancer 3:459-465
25. Spandidos DA, Frame M, Wilkie NM 1990 Expression of the normal H-ras1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes. Anticancer Res 10:1543-1554
26. Zhang Z, Wang Y, Vikis HG, Johnson L, Liu G, Li J, Anderson MW, Sills RC, Hong HL, Devereux TR, Jacks T, Guan KL, You M 2001 Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet 29:25-33
27. Diaz R, Ahn D, Lopez-Barcons L, Malumbres M, Perez de Castro I, Lue J, Ferrer-Miralles N, Mangues R, Tsong J, Garcia R, Perez-Soler R, Pellicer A 2002 The N-ras protooncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Res 62: 4514-4518
28. Li J, Zhang Z, Dai Z, Plass C, Morrison C, Wang Y, Wiest JS, Anderson MW, You M 2003 LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer. Oncogene 22:1243-1246
29. Littlewood TD, Hancock DC, Danielian PS, Parker MG, Evan GI 1995 A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res 23: 1686-1690
30. Dajee M, Tarutani M, Deng H, Cai T, Khavari PA 2002 Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 21:1527-1538
31. Everett LA, Glaser B, Beck JC, Idol JR, Buchs A, Heyman M, Adawi F, Hazani E, Nassir E, Baxevanis AD, Sheffield VC, Green ED 1997 Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet 17:411-422
32. Yoshida A, Taniguchi S, Hisatome I, Royaux IE, Green ED, Kohn LD, Suzuki K 2002 Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells. J Clin Endocrinol Metab 87:3356-3361
33. Arturi F, Russo D, Bidart JM, Scarpelli D, Schlumberger M, Filetti S 2001 Expression pattern of the pendrin and sodium/iodide symporter genes in human thyroid carcinoma cell lines and human thyroid tumors. Eur J Endocrinol 145:129-135
34. Russo D, Bulotta S, Bruno R, Arturi F, Giannasio P, Derwahl M, Bidart JM, Schlumberger M, Filetti S 2001 Sodium/iodide symporter (NIS) and pendrin are expressed differently in hot and cold nodules of thyroid toxic multinodular goiter. Eur J Endocrinol 145:591-597
35. Porra V, Bernier-Valentin F, Trouttet-Masson S, Berger-Dutrieux N, Peix JL, Perrin A, Selmi-Ruby S, Rousset B 2002 Characterization and semiquantitative analyses of pendrin expressed in normal and tumoral human thyroid tissues. J Clin Endocrinol Metab 87:1700-1707
36. Xing M, Tokumaru Y, Wu G, Westra WB, Ladenson PW, Sidransky D 2003 Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis. Cancer Res 63:2312-2315
37. Cobellis G, Missero C, Di Lauro R 1998 Concomitant activation of MEK-1 and Rac-1 increases the proliferative potential of thyroid epithelial cells, without affecting their differentiation. Oncogene 17:2047-2057
38. Avvedimento VE, Musti AM, Ueffing M, Obici S, Gallo A, Sanchez M, DeBrasi D, Gottesman ME 1991 Reversible inhibition of a thyroid-specific trans-acting factor by Ras. Genes Dev 5:22-28
39. Zannini M, Acebron A, De Felice M, Arnone MI, Martin-Perez J, Santisteban P, Di Lauro R 1996 Mapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1). J Biol Chem 271:2249-2254
40. Park KS, Whitsett JA, Di Palma T, Hong JH, Yaffe MB, Zannini M 2004 TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem 279:17384-17390
41. Gorman CM, Moffat LF, Howard BH 1982 Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044-1051
42. Brasier AR, Tate JE, Habener JF 1989 Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques 7:1116-1122
43. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159