Regional low-flow perfusion improves neurologic outcome compared with deep hypothermic circulatory arrest in neonatal piglets

Journal of Thoracic and Cardiovascular Surgery

Volumn 127, Issue 4, 2004, Pages 1051-1057

  Myung, Richard J ^a   Petko, Matus ^a   Judkins, Alexander R ^a   Schears, Gregory ^a   Ittenbach, Richard F ^a   Waibel, Robert J ^a   DeCampli, William M ^a   Sperling, Jason S ^b   Chitwood Jr , W Randolph ^b   Vinten Johansen, Jakob ^b   Woo, Y Joseph ^b   Buckberg, Gerald D ^b   Ye, Jian ^b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE; EOSIN; HEMATOXYLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARDIOPULMONARY BYPASS; COMPARATIVE STUDY; CONTROLLED STUDY; HEART ARREST; HEMOPERFUSION; HIPPOCAMPUS; HISTOPATHOLOGY; HYPOTHERMIA; NEOCORTEX; NERVE INJURY; NEWBORN; NICK END LABELING; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZATION; SCORING SYSTEM; SWINE;

EID: 11144358560     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2003.11.008     Document Type: Article

References (24)

1. Ferry PC. Neurologic sequelae of open-heart surgery in children. Am J Dis Child. 1990;144:369-73.
2. Hickey PR. Neurologic sequelae associated with deep hypothermic circulatory arrest. Ann Thorac Surg. 1998;65:65-70.
3. Wernovsky G, Jonas RA, Hickey PR, du Plessis AJ, Newburger JW. Clinical neurologic and developmental studies after cardiac surgery utilizing hypothermic circulatory arrest and cardiopulmonary bypass. Cardiol Young. 1993;3:308-16.
4. Greeley WJ, Kern FH, Meliones JN, Ungerleider RM. Effect of deep hypothermia and circulatory arrest on cerebral blood flow and metabolism. Ann Thorac Surg. 1993;56:1464-6.
5. Asou T, Kado H, Imoto Y, Shiokawa Y, Tominaga R, Kawachi Y, et al. Selective cerebral perfusion technique during aortic arch repair in neonates. Ann Thorac Surg. 1996;61:1546-8.
6. Imoto Y, Kado H, Shiokawa Y, Fukae K, Yasui H. Norwood procedure without circulatory arrest. Ann Thorac Surg. 1999;68:559-61.
7. Reasoner DK, Hindman BJ, Dexter F, Subieta A, Cutkomp J, Smith T. Doxycycline reduces early neurologic impairment after cerebral arterial air embolism in the rabbit. Anesthesiology. 1997;87:569-76.
8. DeCampli WM, Schears G, Myung RJ, Schultz S, Creed J, Pastuszko A, et al. Tissue oxygen tension during regional low-flow perfusion in neonates. J Thorac Cardiovasc Surg. 2003;125:472-80.
9. Kurth CD, Priestley M, Golden J, McCann J, Raghupathi R. Regional patterns of neuronal death after deep hypothermic circulatory arrest in newborn pigs. J Thorac Cardiovasc Surg. 1999;118:1068-77.
10. Zhang J, Quan H, Ng J, Stepanavage ME. Some statistical methods for multiple endpoints in clinical trials. Control Clin Trials. 1997;18:204-21.
11. duPlessis AJ. Mechanisms of brain injury during infant cardiac surgery. Semin Pediatr Neurol. 1999;6:32-47.
12. Newburger JW, Jonas RA, Wernovsky G, Wypij D, Hickey PR, Kuban KC, et al. A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. N Engl J Med. 1993;329:1057-64.
13. Swain JA, McDonald TJ, Griffith PK, Balaban RS, Clark RE, Ceckler TL. Low-flow hypothermic cardiopulmonary bypass protects the brain. J Thorac Cardiovasc Surg. 1991;102:76-83.
14. Pigula FA, Nemoto EM, Griffith BP, Siewers RD. Regional low-flow perfusion provides cerebral circulatory support during neonatal aortic arch reconstruction. J Thorac Cardiovasc Surg. 2000;119:331-9.
15. Pigula FA, Gandhi SK, Siewers RD, Davis PJ, Webber SA, Nemoto EM. Regional low-flow perfusion provides somatic circulatory support during neonatal aortic arch surgery. Ann Thorac Surg. 2001;72:401-7.
16. Yamashita K, Kazui T, Terada H, Washiyama N, Suzuki K, Bashar A. Cerebral oxygen monitoring for total arch replacement using selective cerebral perfusion. Ann Thorac Surg. 2001;72:503-8.
17. Lim C, Kim WH, Kim SC, Rhyu JW, Baek MJ, Oh SS, et al. Aortic arch reconstruction using regional perfusion without circulatory arrest. Eur J Cardiothorac Surg. 2003;23:149-55.
18. Priestley MA, Golden JA, O'Hara IB, McCann J, Kurth CD. Comparison of neurologic outcome after deep hypothermic circulatory arrest with alpha-stat and pH-stat cardiopulmonary bypass in newborn pigs. J Thorac Cardiovasc Surg. 2001;121:336-43.
19. Bellinger DC, Wypij D, du Plessis AJ, Rappaport LA, Riviello J, Jonas RA, et al. Developmental and neurologic effects of alpha-stat versus pH-sta1 strategies for deep hypothermic cardiopulmonary bypass in infants. J Thorac Cardiovasc Surg. 2001;121:374-83.
20. Lim C, Kim WH, Kim SC, Rhyu JW, Baek MJ, Oh SS, et al. Aortic arch reconstruction using regional perfusion without circulatory arrest. Eur J Cardiothorac Surg. 2003;23:149-55.
21. Cooper WA, Duarte IG, Thourani VH, Nakamura M, Wang NP, Brown WM, et al. Hypothermic circulatory arrest causes multisystem vascular endothelial dysfunction and apoptosis. Ann Thorac Surg. 2000;69:696-702.
22. Kin H, Isibashi K, Mitatori T, Kawazoe K. Hippocampal neuronal death following deep hypothermic circulatory arrest in dogs: involvement of apoptosis. Cardiovasc Surg. 1999;7:558-64.
23. Ditsworth D, Priestley MA, Loepke AW, Ramamoorthy C, McCann J, Staple L, et al. Apoptotic neuronal death following deep hypothermic circulatory arrest in piglets. Anesthesiology. 2003;98:1039-41.
24. Myung RJ, Kirshbom PM, Petko M, Golden JA, Judkins AR, Ittenbach RF, et al. Modified ultrafiltration may not improve neurologic outcome following deep hypothermic circulatory arrest. Eur J Cardiothorac Surg. 2003;24:243-8.